<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07485

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMTEPSGQNGTRTDHERDSIVNGINGAEDANVQNGGGSKDKARNVAASALSNDEGITKGHELVVHRPTEQNTNRMNDLPDHIPHITQGFVPLSLFLTRLAQATHNDLQDKVAELAKMPVPASLSNGNSSYSSSGPDDSSSENMRKKGVLANFAQEYHGKWMKALVITEWSRNSHLVSKLIDLKVHIDQQRMLYDNALDNIVNVKRDLAFARMPSPDLKTALQVLSTGSAPWMPDLQYIEPPPLTPEQQLKWTNDLDTLLSLRLNLDDFDKIPRQFRDYNIESGRVTFKVEGEFEVDLTIADEDFEKQFWFIDFRYAFKPTASPLSESLRAHLEASVNDVLSREGLEGCYHFLHEFVLSSKINELKHQALQLGRTSWTGTLSVESLHRALAIQYWKSRSMTTGSKSWILIAVDSERASQAKAAVGAASQLVISWYRDGKEMRDVQIEFDVNHLSAEGLLTKVIALHVEHVLSSIYGNLSTAARYKGGESTMTLGVSKTNPASSVLSMQVGCNEEISLVVDPMTGGFSLSPRSKFTLQAEHQLNNGKNASEDGVTCLEQMRCVIKEHDLQRRSVRTGWKVRKAGLEVSELKLVTKMREWTRAVWLQREDWGPQWSVVVLLGSGGDEWWLLESDASKATVKLQSKLPLSNGHADMADGFWKQLAFFTTGLIAQSVDLRELHRHRIKSRLSKNRDTLPAQSMRLPSIDMALSDIFPAMVFNTERPDADNGAPEGEEGSDDTKLLSLVQRASGGGPAPAKRAWADNMVDIRFTAIEGSTESEQLGGDGRPGRELTCISEAVVKVRRPSKFASLTGLADEDVSYNAQHGEFSLRIRRQAGRPILDTLKSRIKAIDRFVSFLEAMDGAKGTITTESATLRQISFYYGEAPTLAENGEIVKVEPTKAQPRRWRVVLDLSKDDIGIAVEEGNPHLSLLDLLRRLVNSDGGMSALVVWLPASLPALRAVEEVASSWQQIAAAGQGAFSFSMKSIAWLNLTYTIGAPASVASRAYETVTLQVKLEPRRSQAWWRVWRCEAAPVGGNAISRALQVIWSGRGEGWRGLYTGVVARPHGGIEALLLAIDEVMRKCVGGGTSDDSHDVVVLD
Length1096
PositionTail
OrganismMoelleriella libera RCEF 2490
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Moelleriella.
Aromaticity0.07
Grand average of hydropathy-0.337
Instability index39.41
Isoelectric point6.06
Molecular weight121106.50
Publications
PubMed=27071652

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07485
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.48|      24|     394|     624|     669|       1
---------------------------------------------------------------------------
  527-  550 (43.70/15.81)	SPRSKFT..LQAEHQLNNGKNASEDG
  629-  654 (37.79/43.28)	SDASKATvkLQSKLPLSNGHADMADG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.10|      36|     613|     402|     474|       4
---------------------------------------------------------------------------
  402-  440 (52.20/59.81)	SKSWILIaVDSERASQAKAAVGAASQLVisWYRDGKEMR
 1017- 1052 (69.90/22.78)	SQAWWRV.WRCEAAPVGGNAISRALQVI..WSGRGEGWR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.31|      15|     454|     305|     327|       5
---------------------------------------------------------------------------
  230-  244 (32.03/10.51)	WMPDLQYIEPPPLTP
  308-  322 (30.28/16.01)	WFIDFRYAFKPTASP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.86|      23|      28|      69|      93|       8
---------------------------------------------------------------------------
   69-   93 (39.25/35.81)	QNTNrmNDLPDHIPHITQGFVPLSL
  100-  122 (40.61/28.97)	QATH..NDLQDKVAELAKMPVPASL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.10|      51|     188|     730|     783|       9
---------------------------------------------------------------------------
  730-  783 (79.29/77.18)	EEGSDDTKLLSLVQR..ASGGGpAPAKRAW.ADNMVDIRftAIEGSTES.EQLGGDGR
  919-  973 (73.82/57.67)	EEGNPHLSLLDLLRRlvNSDGG.MSALVVWlPASLPALR..AVEEVASSwQQIAAAGQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07485 with Med14 domain of Kingdom Fungi
Unable to open file!