Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDKFIDGRFERLEKALTSLIDSVTKYHPSMNLAEEVVAADAELTKGLEQVQTHQNNHLRILELREASASLDTQIRDTLTSLANARRDIVNTHTTKFPSAPNYPIAYEELLSYARRISKTTMPPAGTINASVAPSGLQSPTVGESQSQAVTPAPTTPAAGATPGAATTPATTTPLPTQSPAAVNGVGGGAQHPHAPQQGGSSSGPSLLTSLPEPMAQYLNPLSGQVFFPWPLEDKIRSGSLAANQVLVEKGIDPRGFDPVAEEERKRREEAERKEREEREAREQQERDRLMREERERARLERERQREKEQEEWRRASVVAGTADAPGAAAPKAPEKKQFQFTNLDDLDDDDDDD |
Length | 353 |
Position | Middle |
Organism | Cordyceps fumosorosea ARSEF 2679 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Cordyceps. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.813 |
Instability index | 51.18 |
Isoelectric point | 5.09 |
Molecular weight | 38717.34 |
Publications | PubMed=27071652 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP07484 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 40.43| 14| 15| 275| 288| 1 --------------------------------------------------------------------------- 257- 270 (20.26/10.19) DP..VAEEERKRREEA 271- 286 (20.17/10.11) ERkeREEREAREQQER --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 71.71| 15| 15| 150| 164| 2 --------------------------------------------------------------------------- 150- 164 (27.64/12.18) TPAPTTPAAGATPGA 167- 181 (25.29/10.55) TPATTTPLPTQSPAA 186- 199 (18.78/ 6.06) GGGAQHPHAPQQGG. --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 80.79| 25| 28| 84| 111| 3 --------------------------------------------------------------------------- 84- 111 (40.90/32.59) ARRdivNTHTTKFPSAP.NYPIAYEELLS 113- 138 (39.90/23.79) ARR...ISKTTMPPAGTiNASVAPSGLQS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 31.84| 10| 17| 202| 214| 5 --------------------------------------------------------------------------- 202- 214 (10.16/14.59) SGpSLLtsLPEPM 222- 231 (21.68/11.35) SG.QVF..FPWPL --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AAAPKAPEKKQFQFTNLDDLDDDDDDD 2) PIAYEELL 3) WRRASVVAGT | 327 103 312 | 353 110 321 |
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