Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDKFIDARFERLEKALSNLIDSVTKYHPSPIHAEELKAADEELTKGLEKVQLHQNNHHRIRKLRQSSAALDAQIRDTLTSLASARKDIVTTHTTTYPSEVNYPIGYEELLSYARRISKTTLPPAATIESAGPVANAANQSPHAAAASESQSQLAALTPSAAAHSQPQSPTAVNGTPTGHPPPSSSATATQQSTTTVSLNTSLPEGMSQYLNPLSGQLFFPWPLEDKIRSGSLASYQVLVEQGIDPKGYDPATEEERKRKEEEERKAKEEQEKAEREAREKQLREERERARIERERQREKEQEAWRRASIANAQPEGSGPSKPNAASPEKKQFQFTNWDDLDDDDD |
Length | 345 |
Position | Middle |
Organism | Moelleriella libera RCEF 2490 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Moelleriella. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.991 |
Instability index | 60.23 |
Isoelectric point | 5.54 |
Molecular weight | 38384.75 |
Publications | PubMed=27071652 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP07479 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 62.80| 20| 27| 158| 178| 2 --------------------------------------------------------------------------- 158- 177 (38.40/17.00) PSAAAHSQPQSPTAVN.GT..PT 182- 204 (24.40/ 8.43) PSSSATATQQSTTTVSlNTslPE --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 42.28| 13| 17| 278| 291| 4 --------------------------------------------------------------------------- 278- 291 (18.33/15.44) REKQlREERERARI 297- 309 (23.95/15.15) REKE.QEAWRRASI --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 117.74| 36| 71| 1| 36| 5 --------------------------------------------------------------------------- 1- 36 (62.25/46.13) MDKFIDARFERLEKALSNLIDSVTKYHPS....PIHAEEL 70- 109 (55.50/40.32) LDAQIRDTLTSLASARKDIVTTHTTTYPSevnyPIGYEEL --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) GPSKPNAASPEKKQFQFTNWDDLDDDDD 2) KEQEAWRRASIANAQPEG | 318 299 | 345 316 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab