Description | Mediator of RNA polymerase II transcription subunit 6 |
Sequence | MDNPNDPPLDEIQWHSPQIIQQMGGLHSNTILFYFAESPFFERTSNNAVIMSQAMNNMSMYHFIQTREAFEGRLKTMSGLEFIVGEEPAETGPGMGTGVWVIRKQTRRKRFQEADEITIHASYFVVNENIYMAPTLADILAARIMSISSSISKALPAAESARSWRPAGGHYYKPPRAQASGPAGALHAARARIQESKEATPTPTGSSGGGGANKGTSTTAPPNLEVQSLERVAEEAFWVHMRYGGEYIDENPITGRPGDFHLSSTGRKPVTAPRSVAAGQLGPAGISAMTGPPVRGGKADDKKDGGVASAAAKGDKAARSAMPKPKRKKSKLGGTGSRTPTAA |
Length | 343 |
Position | Head |
Organism | Cordyceps fumosorosea ARSEF 2679 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Cordyceps. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.510 |
Instability index | 51.55 |
Isoelectric point | 9.56 |
Molecular weight | 36621.88 |
Publications | PubMed=27071652 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364143 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP07478 No repeats found |
MoRF Sequence | Start | Stop |
1) ADDKKDGGVASAAAKGDKAARSAMPKPKRKKSKLGGTGSRTPTAA 2) ARARIQ | 299 189 | 343 194 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab