<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07475

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMATDTVTAVTMTTAAAAASPIRSPRRNRPSSGASASATATTARPFVPAIRNALQWAHFLDRCLATRLNVSRFAEFARIQQCKHPVSPAVLADLCLRPPVPRRFPIPFAPPRGAKQESETAGNESNRSEDGRRRRRRRRSSSSAKAVAAHRCDAFIDPRIPAYLQVLLQRGYVDVASVLRALYRYSTSHRLVRNDGGRTASEQQHERGEGDGDGDGHGDNSNDAVMTTGDDGQGEEAKPAADAGDAHKNGSLDANDDAGGGAGASGTGGTAPSASNAAGPVYWASSYNNEETLFYQISRAVREGGAIRDQRSALLVASNMAQWLELYAAAAAACAGGNAGTDAGIAAQSQTQIEMESTRAAFVMLLLSVCEDKTVLSALAQPFAKSTRKALSEKLGNFLPLISLSSSHIAARLELFLMETLASFDPVDKKVEEETNEMIDFLDSTAGLQGLVLPELPITNSRAGLYIYLNAALVGRPLIDDVAIFSYLHNRYHGDLQTTAIDLILASFDVLANAVFRTEGQTSAHLLRSFLINKTPLLLASLAASPLYPFDSQYCISEALSRVDTNAFPTMSSMFDDNQNTNPFTDSVRQDFCFACCLHGLIPEASIETLLGEMTYQSLPAGGRHTKEQLLQQCLHNSEQMVALVGQLDNMDGNVGAVCQALVALLGHLCRTKETATLKVLCNQLVRKPLAFDVILLFERPAALLYPLAQLLDTWRYDDDQGEYQPVYEEFGAVLFLLLAFVHRYNLSIADLGIQWSPDSFVAKLLSTGHLGRSLAEITDPERENLGNWIRGLFDTDAGGLSDDLMASCPPQQFYLLTPTLFQQMVQAFVSSEMSVDVLKCGIEYLVDTFLLPSLVTALLYLSDALRFERPNEQKAIIRVLQLILQPASISHDATMMLSALLNIVAKPLEHALRTFQRQDPKNQDIDPLLRTLKENIPRSRRTGAAEHNELVTWASTSSNTTGMAGGGGGGNAGGGGVDNHSSTNGGLYAAIRQTMQGFVQWSLHPGVNIMPTSYTHRQFLAGLSLLGAPRLLQLILDEVQRQTEAGSGSVAYDVACALVCAPDVTNDASPETLYVLVGSDGVGGGGDDDNGQGGHSHGPPSGSTVPNPAAVQRRMTLRQALAYKAEEWKKMQRSRDAAEVAMAETTVRLYLKVEAQLTPPTPPPPPPPNQPDPSVPNPSDGVMAGELAALDVDDSTVAAAAAHLDDNMDMVAAAAAADSSVGAGGDNMVLDGMDLSNLGGNNGGGGGGGVGGVGGGDGGQQGGVGGLGGGDLGDQLGDLANLGDLGDLGDLGNLGGTGDGGGDIGGLDMTDQSMFGDLNLLDSFMDLQ
Length1328
PositionTail
OrganismSporothrix insectorum RCEF 264
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Ophiostomatales> Ophiostomataceae> Sporothrix.
Aromaticity0.06
Grand average of hydropathy-0.157
Instability index46.58
Isoelectric point4.88
Molecular weight140896.60
Publications
PubMed=27071652

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07475
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     299.68|      45|     277|     943|     987|       1
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  231-  278 (52.57/17.53)	GQGEEAKPA...ADAGDAHKNGSldandDA...............................G..G..GAGASGTG..GTAP.SASNAAG..
  943-  987 (77.99/29.20)	GAAEHNELV...TWASTSSNTTG.....MA...............................G..G..GGGGNAGG..GGVD.NHSSTNGGL
 1027- 1104 (45.73/14.39)	GAPRLLQLIldeVQRQTEAGSGS.....VAydvacalvcapdvtndaspetlyvlvgsdgvG..G..GGDDDNGQ..GG.H.SHGPPSGST
 1222- 1267 (69.53/25.32)	GAGGDN.MV...LDGMDLSNLGG.....NN...............................G..G..GGGGGVGG.vGGGDgGQQGGVGGL
 1268- 1318 (53.85/18.12)	GGGDLGDQL...GDLANLGDL.G.....DL...............................GdlGnlGGTGDGGGdiGGLDmTDQSMFGDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     502.66|     137|     141|     537|     677|       2
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  423-  573 (159.52/99.68)	FDPvDKKV.EE.ETNEM.IDFLDSTAgLQ..GL.VlPELPItNSRAGLYIYLNAALVGRPLIDDVaIFSYLHNRYhgdlQTTAIDLILASFDVLANAVFRTEGQTSAHLLRS...............................flinktplLLASLAASPLYPFDsqycISEALSRVDTNAFPTMSSM
  574-  711 (220.18/127.65)	FDD.NQNT.NP.FTDSVRQDFCFACC.LH..GL.I.PEASI.ETLLGEMTYQSLPAGGRHTKEQL.LQQCLHNSE....QMVALVGQLDNMDGNVGAVCQALVALLGHLCRTKE....TATL...........................kvLCNQLVRKPL.AFD....VILLFERPAALLYPLAQLL
  716-  863 (122.96/66.93)	YDD.DQGEyQPvYEEFGAVLFLLLAF.VHryNLsI.ADLGI.QWSPDSFVAKLLSTG..HLGRSL.AEITDPERE....NLGNWIRGL..FDTDAGGLSDDLMA....SCPPQQfyllTPTLfqqmvqafvssemsvdvlkcgieylvdtfLLPSLVTALLYLSD.......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.00|      12|      15|     912|     923|       3
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  912-  923 (21.84/14.74)	LRTFQRQDPKNQ
  929-  940 (20.17/13.00)	LRTLKENIPRSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.69|      38|     107|      22|      61|       4
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   22-   61 (62.34/37.63)	RSPRRNRPSSGASASATATTARPFV.PAIRNALQwaHFLDR
  131-  169 (62.35/31.52)	RRRRRRRRSSSSAKAVAAHRCDAFIdPRIPAYLQ..VLLQR
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.44|      28|    1061|      95|     122|       7
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   95-  122 (53.76/23.15)	LRPPVPRRFPIPFAPPRGAKQESE..TAGN
 1157- 1186 (53.68/23.10)	LTPPTPPPPPPPNQPDPSVPNPSDgvMAGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.13|      10|      27|    1188|    1197|      10
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 1188- 1197 (16.58/ 8.85)	AALDVDDSTV
 1212- 1221 (15.56/ 7.82)	AAAAAADSSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      28.46|       9|      25|     992|    1003|      11
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  992- 1003 (12.41/15.02)	RQTMQGFvqwSL
 1017- 1025 (16.05/ 7.31)	RQFLAGL...SL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07475 with Med5 domain of Kingdom Fungi
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