<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07466

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMAADSMPLMLSDNLGAMGDGMHVGLQDVDVDDVDLFGGPVDLGLPPQQPPPSKQLQMRVDEMRTRGCSQRIGWSRQGTIASIGADGQSIDVRYLRTDPRDGSWGLSEPTHYAQFSHVNTVTTFSGGPIVHLAWAATGHPELAVIDAVGRVSILAFTLSLNRPFPLRSWELDPVDDLHAVVGCYWLPLIPHGKQAKYHLIHGPAVREDHGYRYDNTGAHAFGPYHPNASKSSLLCVTAGGTLRLLYPQSNNAVQETSMELESITSSDDLATHASICSEKGNSLLIALATASRQLKVVRAAIHWNLPPHDKQVPPHTVQLNPMLQQKPAAVTTWLQHGAGELQLDISADQISHLEVLSSAAVGPNQPWSPPLVLTVRTYMPTPNTSPYQQPDAQSIIDRWELLVDTPPQPLHPAFEQVGIKPRPQQQAQAQANATGLTRLHKLEPIFLNKVVVAVHTIQFGKVVCFAFSDGTVQYRDRFTMQEIYTEPNHERIFTLQEANFHFTDNVAEYAAVVAGLTTTMATAQHSQSSYDDVLAVARQFVDKPRFAFDWMMEIVRMLKINVDYSEEAHHDQLVRNHALHSCFSILNHMGFRGEFKPRAFCGKFAMLTMNVRNIVILITIASNTPGNSKDRHNPLDEPDVVDALAGCAKWALDLLAYIADCVFNLLDDPAFMALLSGHNFNELAAYLQEKNDVALHLLLCSSTRGFLSAVCRRLLHLDSISARATQYYEQQQQQQAAAGANGGAAATAGGVQRPALILPYQKMQQYTSSSLIKVQEFDKLLLTLGEEIRQTYQAQIAQTTNATAGNGQKTNGGKAKQQAPNGQQQNQTADANLKRLQAHCELTLLLGNNPPPKFQPMLQKFFSEHLRAFRAQTDPAKLYFADYSILEVEDDEHSLRTRRMRHSHVDVFKRVELTMPTSGMSGHGGGGGGGGGGVGGGGGGGGSGGADATAWPPTGLGATGLWRRCARCTAIMEDVAGLRPAYMFVLAQQRNRRRLSGPAGAQAALREQNPIIFHILPRGAPWCDMDKDGVDDAAAADAQLRVLPEKEIHMLGLIVERQHTTPAQLCNTGPLDDQPPHMETNPLSLVPRPAPKPSPKPALKPMPSPQSISSGDPMGVYSTMYWREARQKVLCWLSSMDGIDCEPDWILALNPHDETGGTSLKVGLPAGSALLADAHLGDSIAINGCCLTVTAFDATSFQVGIAPETLRLTNLGDLAPDTNTTAGHNPNSRVNLERAVRADTRMGGHFVQGHVDTVARVTRVAPDGNAQTMRFAPRDRSVLRYVVHKGFVALDGTSLTVTAVNDQEGWWEVMLIAYTQSRVALAAKREGDTVNVEVDVLAKYAEKSMAGYLETTAGGDGGVKALVQKAVADALAAQGQ
Length1375
PositionTail
OrganismSporothrix insectorum RCEF 264
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Ophiostomatales> Ophiostomataceae> Sporothrix.
Aromaticity0.07
Grand average of hydropathy-0.252
Instability index38.11
Isoelectric point6.16
Molecular weight149440.63
Publications
PubMed=27071652

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07466
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     155.21|      38|     257|      40|      77|       1
---------------------------------------------------------------------------
   40-   77 (71.90/46.63)	VDLGLPP...QQPPPSKQLQMRV......DEMRTRG..CSQRIGWSRQG
  244-  281 (26.38/11.81)	....LYP...QSNNAVQETSMELesitssDDLATHAsiCSEK.GNS...
  300-  336 (56.93/35.18)	IHWNLPPhdkQVPPHTVQL..........NPMLQQK..PAAVTTWLQHG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     148.59|      48|     257|     708|     758|       2
---------------------------------------------------------------------------
  708-  758 (76.97/45.12)	AVCRRLLHlDSISARATQYY..EQQQQQQAAAGANGGAAATAggVQRPAL..ILP
  965- 1016 (71.62/33.55)	ARCTAIME.DVAGLRPAYMFvlAQQRNRRRLSGPAGAQAALR..EQNPIIfhILP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.14|      30|     257|     777|     819|       3
---------------------------------------------------------------------------
  785-  814 (51.73/41.05)	EEIRQTYQAQIAQTTNATAGNG..QKTNGGKA
 1203- 1234 (46.41/14.53)	ETLRLTNLGDLAPDTNTTAGHNpnSRVNLERA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     242.92|      73|     200|    1111|    1183|       6
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 1111- 1183 (129.19/76.59)	DPMGVYSTMYWREARQKV.LCWLSSMDGIDCEPDWILALNPHDETGGTSLKVGLPAGSALLADAHLGDSIAING
 1301- 1374 (113.73/66.53)	DQEGWWEVMLIAYTQSRVaLAAKREGDTVNVEVDVLAKYAEKSMAGYLETTAGGDGGVKALVQKAVADALAAQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     250.63|      74|     463|     166|     241|       9
---------------------------------------------------------------------------
  166-  241 (133.45/76.34)	RSWELDPVDDLHAVVGCY.W.LPLIPHGKQAKYHLIHGPAVRE.DHGYRYDNTGahAFGPYHPNASKSSLLCVTAGGTL
  630-  706 (117.18/61.67)	RHNPLDEPDVVDALAGCAkWaLDLLAYIADCVFNLLDDPAFMAlLSGHNFNELA..AYLQEKNDVALHLLLCSSTRGFL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07466 with Med16 domain of Kingdom Fungi
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