<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07465

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDVGEYETNTLVVSHIASVAFRVYRHVATSSSSVHAFSSTDIEKALRTDGHLVFADSRRRGIWCFRLLRKDGTRIGSPAKSELGATIAIGPHRLSMVDEGAFEPSSLLKGRPTITNAIKTPNSSSSSSGLSAIDSASKTAINQQFGLPPPSATPTLSQASTVLTNATVPPDAETAPAGSRPPGTDTAEQRTFPAVPAKVVYNFFLSSVLASLSSAYCSKANAIALNSRTFLLPPLDPLWDGEESSRADRKSLVATLRVCLTTAGALLVSLSHSILQGMGCSTWACYDHVPPAGASVLTAPWGKLATIRDVYPPLPPDEAGPYASTTSGGTRLLPSVPQAWKNFVAQMLEMRGTSPSVMRDSSWLRVEFLLEEETGSSKPVVILWPSVLCFWSLENPSATVALFQRLDPLADVREAYLEELRGEDVASKPLEAKEDEDVFMEDAPTVSSTGKGSQSDGPSPLGMRNSTGLVSAAAAAAAAGTVYPTPPDGVSNPVGVTPTFDGSVSSPGNAVGTVAPADSDAPATERSLATEGTFGDFWQSNELKREEHDQPFIAEPENLFGEMGVDMFGDDVTDADFNFFDKKPDAAGVPLPGASDAATTTLGETDIDTTMTQASPQTKVEGQSPAEKPRENLAISSFADGKSNEILGESVAQGRPEPSMFAKPELKHARSNLNDETRDANFLFKTSANGGPVYRTKRPPSPFNAMTVFKRVRTLVAAKRAQSGWAKQSTLARHGNRFEGLRFTDFMLQNNKKYEQNGKFSFVWPHPEADMAFDMSSATSPTAFRRPVKKKPGLEEQSPAFSALVSSITRNLKSSSLRPQSPPLVDNSEDTSSGSSGPDSSSSDDTDDDEPLAASMAQRKLKARMIAEAVPLPEAATELSRVYSEGVWDFPITRFFADPMPPQTELAYTDDDIADVAQILTQQITRATIRSGFDEDSGQDLQHSKLRQTLLQRTRYSIATLQSCLPPGLHDATRCSLKLYLEVQDIPLLVQPSRLHPRPPPGSEQLRTNFFPVPTPHVELRRNESALSIMPTAVEFWEVLGLEPLHGAKDIKAVCLYPNYDGLAEEVGNFIGRMRIVYESLRLGSHEPLSDHAAVSNGMASFDASMPYAASSGSATGRSDFLGADQMHKLAQALAAEDTPSKSLLVYHVYCADVTNAIVDACLAFQRLSQLYEIAVTSRNTEPNDLVLQLIPTSFLASSTCLVVPTPTDLFRLSLEVYDRCASPRGPRPSPAFLLEQPPSRMLDLKLSATPSVDVQRENSCIHVAYAQSADNRWVTAAWTDSSGWRQFSAAYRVARKGMPPTNSFAAVAQEMWENTCALVASLKVHWRAVITKCGTMEQDEVQVWTELAKVESRASISVTLVAVDTRPSLELLPPVVTVPPTALSLLSAATPAPTPQASVFSPEQSGNPVTPVANTSFGNPTTPAGTPAGAPTPVTPSAAATTNTGTGAGGGGGGPNSPAVANTSGANANSDPSAKLAAAGADPNTVAEIDGNVVLVDITDSTWGAVAAHRLNTSSTWVDVRPALVSGYLVKRGGMGRDDPPVVLEVNVIRAEGSPRGYESLVREILSSFRGLGTLARARGILDGERDVRPWHVAAAERSAKALCQWM
Length1608
PositionKinase
OrganismSporothrix insectorum RCEF 264
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Ophiostomatales> Ophiostomataceae> Sporothrix.
Aromaticity0.07
Grand average of hydropathy-0.251
Instability index46.63
Isoelectric point5.26
Molecular weight171841.91
Publications
PubMed=27071652

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07465
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     112.20|      25|      27|    1409|    1435|       1
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 1375- 1403 (26.30/ 7.80)	PVVTVPPTalSLLSAATPAPTPQAsvfSP..
 1409- 1433 (49.17/19.76)	PVTPVANT..SFGNPTTPAGTPAG...AP.T
 1434- 1458 (36.72/16.32)	PVTPSAAA..T.TNTGTGAGGGGG...GPnS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.16|      27|      31|     456|     484|       3
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  456-  484 (45.31/24.82)	DGPS.PLGMRNS.TGLVSaaAAAAAAGTVYP
  488-  516 (41.85/18.02)	DGVSnPVGVTPTfDGSVS..SPGNAVGTVAP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.92|      18|      22|     811|     830|       4
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  813-  830 (32.55/19.82)	KSSSLRPQSPPLVDNSED
  832-  849 (29.37/10.79)	SSGSSGPDSSSSDDTDDD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.26|      20|      31|     922|     952|       5
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  927-  950 (27.90/48.24)	ATIRSGFdedSGQDLQHsKLRQTL
 1115- 1134 (37.36/17.50)	ATGRSDF...LGADQMH.KLAQAL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.96|      19|      31|     518|     536|       6
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  518-  536 (34.53/20.16)	DSDAP..ATERSLATE.GT..FGD
  547-  570 (23.43/10.98)	EHDQPfiAEPENLFGEmGVdmFGD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.54|      17|      24|     286|     302|       8
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  286-  302 (33.31/14.76)	YDHVPP..AGASVLTAPWG
  311-  329 (30.24/12.58)	YPPLPPdeAGPYASTTSGG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.20|      33|      33|     624|     656|       9
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  624-  656 (55.75/37.04)	SPAEKPRENLAISSFAD.GKSNEILGESVAQGRP
  659-  692 (53.44/35.16)	SMFAKPELKHARSNLNDeTRDANFLFKTSANGGP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.64|      22|     152|    1345|    1370|      10
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 1345- 1370 (28.94/28.42)	WTELAkvESRASISVTLvaVDTRPSL
 1504- 1525 (41.71/26.04)	WGAVA..AHRLNTSSTW..VDVRPAL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.36|      40|      43|    1144|    1183|      11
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 1144- 1183 (68.54/44.70)	L...LVYHVYCADVTNAIVDACLAFQRLS.QLYEIAVTSRNTEP
 1186- 1229 (61.82/39.52)	LvlqLIPTSFLASSTCLVVPTPTDLFRLSlEVYDRCASPRGPRP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.98|      17|      20|     104|     120|      12
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  104-  120 (30.09/16.56)	P..SSLLKGRPTITNAIKT
  121-  139 (23.89/11.55)	PnsSSSSSGLSAIDSASKT
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.20|      15|      20|    1544|    1558|      13
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 1544- 1558 (25.78/15.20)	VLEV.NVIRAEGS...PRG
 1563- 1581 (16.43/ 6.82)	VREIlSSFRGLGTlarARG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.12|      13|      28|     864|     879|      14
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  864-  879 (15.23/15.95)	RMIAEAVPlPEaaTEL
  894-  906 (25.88/13.13)	RFFADPMP.PQ..TEL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     193.59|      56|     816|     144|     200|      15
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  144-  200 (94.13/50.62)	QFGLPPPSATPTLSQASTVLTNATVPPDAETAPAGSRPP.GTDTAEQRTFPaVPAKVV
  962- 1018 (99.47/50.29)	QSCLPPGLHDATRCSLKLYLEVQDIPLLVQPSRLHPRPPpGSEQLRTNFFP.VPTPHV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07465 with Med13 domain of Kingdom Fungi
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