<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07464

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMENGALNGAVHTNHDRDPDKDVDSIANMNGTGSGRDANGGQVDGAVGSSSANMVNGNNNDGIKNNGGREQDEGAAPAFAPAGAQLASTQSARMNDLPDAIQHITSNFVPLGFLLRRLAQKTHNNLQDMVRELARKPVAGMTMNGGGAAAVGASGSPLMPGAEDGSVENIEKKKALLDFARSEHANWVKALVIAEWSKKATQISKLIDLENHMFEEELVKYEQAVFTMLNLKRNLNAARVPSPDLKTALQVLSQGTAPWMPDLGFLAPPPLTPDEKLKWLDDISTLLSLRLNLDDHDNIPYHFRDYTIASGRVTFTVPGEFAVDLTLGSDDFSEQLWFLDLRFLFAPASADLTPGLRKALEDRVNSVLATEGLVGCYRCLHEYVLTHQINELRRQALELGRGRWVETLRVEQLNRAVSVQYWTSRAAAAAAAAAATTTTTTAPPPPTSSNTAAAAGLKSWFIIGVHSGRDAARPVPEEQVTSRLGLRWFRDNKEVKDVDVAFLTGLGLGPSAEDARDAADATATATATTLSAERIVQTIVALHIAHILTGIHAKLLAKPLFVKRRAAVCLRTSKTDPSASSLTVQLTHRDRICIRIDPVTGLFALAPPSRIAASSEYRINSTVAASGKDPVDEGFAMLDSLRCLSLQDDLSRRAKSYGWSVVRNNAGVVKPDELRQVVNLRDTYQVLWLTRPDWAPLWYLLASFSLSGDRWWLVKLNNNDSGARIETKIPLPVGESPTDVNDTFFSDLTVFATGLIAQYTDARELRRRNNTAKAARVANPYLPALAKLPALSLRLSELLASSSSNGDGDKPAGRRSAWALDFVQLLFRGVDVDSFSTERARRIGVLAEARLTVTDRAKFRLLGGSSSSSGGGGGRAGADHDVAFNARTGQFCLYLRAQVGESIIETLVSRLRALERLVGFLDAIRRENRVVRCETVTLRKLVFSYGAASSGGSDDGTHRRWKVAVDLAKATAVRLQLERGCPHLRVVDYLNRVANDPATFAAVPFFLATTLSLHQALDRMEDAWGAIQMRNGGLLGIFPRALDWVVVRFFVRGPHGRARQLVIEIRLKTRHGASLWQVRRLESGTEQQSQSQAPEDELNKAMVRIFSNSGPGWRGLLTAIVASPWPVAANGDGGEGGNSSSSSTTDGIGNCLALIDESVRAMLAVPPPTTTLSVTQMQQRRAQAAQAQAQAQAQATQQQQQQQQQQPPLPPGPPQLTNPGPQAQTAWMA
Length1228
PositionTail
OrganismSporothrix insectorum RCEF 264
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Ophiostomatales> Ophiostomataceae> Sporothrix.
Aromaticity0.06
Grand average of hydropathy-0.245
Instability index42.43
Isoelectric point8.83
Molecular weight133136.01
Publications
PubMed=27071652

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07464
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.99|      19|     336|     794|     820|       1
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  794-  812 (33.88/25.02)	LSELLASSSSNGDGDKPAG
  858-  876 (34.11/10.01)	FRLLGGSSSSSGGGGGRAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     365.18|     129|     161|     309|     469|       2
---------------------------------------------------------------------------
  309-  469 (177.91/155.97)	SGRVTFTVPGEFA.VD...LT.LGSDDFSEqlwflDLRfLFAPASADLTPglrkaledrvnSVLATEGLVGCYRCLH.EYVLTHQINEL........RRQALELgrgrwvETLRVEQLNRAVSVQYwTSRAAAAAAAAAATTTTTTAPPpptsSNTAAAAGLKswfiIGVH...SGRD
  483-  628 (187.27/99.63)	LGLRWFRDNKEVKdVDvafLTgLGLGPSAE.....DAR.DAADATATATA...........TTLSAERIVQTIVALHiAHILTGIHAKLlakplfvkRRAAVCL......RTSKTDPSASSLTVQL.THRDRICIRIDPVTGLFALAPP....SRIAASSEYR....INSTvaaSGKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.35|      48|      77|      61|     108|       3
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   61-  108 (82.46/49.65)	GIKNNGGREQDEGAAPAFAPAGAQLASTQS.ARMNDLPDAIQHITSNFV
  139-  187 (78.89/47.15)	GMTMNGGGAAAVGASGSPLMPGAEDGSVENiEKKKALLDFARSEHANWV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.09|      44|     721|     243|     293|       4
---------------------------------------------------------------------------
  243-  288 (76.16/49.26)	DLKTALQVLSQGTAPWMPDLGFLAPPPLTPDEklKWL.....DD....ISTLLSL
  678-  730 (73.92/34.10)	NLRDTYQVLWLTRPDWAPLWYLLASFSLSGDR..WWLvklnnNDsgarIETKIPL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07464 with Med14 domain of Kingdom Fungi
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