<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07451

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLTDSSLTNILIVSGVSQIRYRVYGQHCKRSSLVDFIKCEPSESSTTGNIKPTYSGFHGDPLDPTENILIKTFKTLTQLGILCMWRMASENNECSSSPTQNPDQDIVPLELWVFWFDEKHTGKIDSNYELSILDELKVGSFTWENVSSKGVSPTASPLALHPRVGSSSLVAVSEEYKLFMKSIQSVIQWSIQQKGAIPLGDFLLFPLNIPDNNDTEMEMKLSPEESTDEMVDSVLSCTYNVYLASTNLIIQPSPRRMRIRPLHISDLKNENLKVRIGPSGEYAKIAPQQDISQQLETNVLLQWSLLFSIPVRYISRPIRKNNSQVIPQLTTILTLRNELVLYPTALIFVPVSAQQHSTPAAGMNSTLRYNQGYTEDLGEKWSRQTWNENIINTTKLHNQNMSMVSDEYGQRIDGLRRHINYWSYMGPKEIVMSNIFEVLSTSDGCSSQELLKKALAEPVLSSPLMVAKSLATPTSLGPKAESVSNDMAEDMEDTDSRISESFENYTGISLKEFATTFFLENANQMLAPNLLISADHKSTTPNSEDNTRGEYIQGLEISQNIDINGFNISESAGRNMPTQPLLQTNEIIASNEAGVLQNLLSGPIQNEMISSNSDYLAPEMTGSNGDIDSGFDIGGMAGMAGIDSMDTMMYGMPDRWGGDDNLDDYDNFDFSVTEEDFKFFESGPNNRHDEYISTAHGGLTTGIQEAQSLDVTDPTLLLIDTFTEKGLGENEMKEKELDFSELFAASRSMMEDTMMIDQSTRIFDESKPIIDSSILMENTAGGHLALDSEDTLMTDVDTMDNHHSSFSNHQFSSTITPKTGQHGLDVVSNQYFVQSELSPVIFSERVNDAKYYNGGKFMYVPPSEKNKTANRKTKQDIYRPDYIPVIKKRVQKWLDDRHPKHQHKAYDNSVKTVSSPIKKPKTEFEDVISSSSSSCYTSSSSSYESESESDSETEVKPIEKSGTKDIIATPKANNAITVQKHMGLLKCEQDIFVSRILIKPGETQKYPLFEKDLGSEYTHPFAEAVVPGPVNSVHLPNEALCEEDYRALDSLFQQVVMGGYPFSGSLAAVSANAGEISEGESATMIVARRRDLIQSLHGDISHIPSLASDYTRITQSFKIILTDIFDQRKFNQTSLYPSGMDHPALPSFVSVKGPLNVQQYYDLSETNQAHSKYGKYQIKKRRPAEPNLDTLIPPNIVVSRQENLLEGSPKLLTFWEKLRLAPYSPPKNINYFVVFPKNEDLESNVSHFFRGLSTVYDTCLLGSHYPAKIGNYRRGLVPVPILPRLQEETWDDQQLRSYTAECRNLGAALRTANAENMHIVIYIVNPSSHLSANLELSRCFRKLVVEYQKTFQDSLSKPTDKNRARLVMQLIPIEHILRSTSFGGYLKFGFKEVAFSVYTKCHTVVGRNHGQVGNNEIQSATELYTPPFVLAKPIPETINFSVKEGPHSFPIILEDNASLHLGYCFSIDHRWMILVWTDHRGELIEFSVLDCIKNSNGSLSAVFEEAWWRTKEISRRTGFPWTYVIAKIGLMFEDELKAWMDIIPNDEKAVIVCVDMESTLYLHLTADATSIPYEQSHTPNSGGVLSSDILNNSPSMNANATHSTRPTDSTDGEVEDTHALLLNHRVAYSRKREKISEGILCMDPNSEVEDWMLPLASGYMVHKAPENDSPCKEQFNHRPLVVEVHLVYNQTAYSAYSTLRDIIKRYHALSFVNSMPSSVNRLPIHLVLVERLCRILLVVDPSF
Length1743
PositionKinase
OrganismPhycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Phycomycetaceae> Phycomyces.
Aromaticity0.08
Grand average of hydropathy-0.385
Instability index48.21
Isoelectric point5.20
Molecular weight195731.44
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07451
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.29|      18|      38|     615|     632|       1
---------------------------------------------------------------------------
  615-  632 (33.80/20.56)	YLAPEMTGSNGDID..SGFD
  650-  669 (31.49/18.58)	YGMPDRWGGDDNLDdyDNFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.91|      25|      39|     862|     886|       2
---------------------------------------------------------------------------
  839-  859 (24.20/13.39)	PVI............FSERvNDAKYYNGG...KFMY.......
  862-  883 (31.76/20.31)	...............PSEK.NKTANRKTK...QDIYRP..DYI
  884-  925 (23.95/13.16)	PVIkkrvqkwlddrhPKHQ.HKAYDNSVKtvsSPIKKPktEFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     186.88|      57|      62|     129|     190|       3
---------------------------------------------------------------------------
  134-  190 (94.82/56.83)	DELKVGSFTWENVSSKGVSPTASPLALHPRVGSSSLV..AVSEEYKLFMKSIQSVIQWS
  195-  253 (92.06/46.42)	GAIPLGDFLLFPLNIPDNNDTEMEMKLSPEESTDEMVdsVLSCTYNVYLASTNLIIQPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.73|      21|      39|    1211|    1231|       5
---------------------------------------------------------------------------
 1211- 1231 (39.68/33.10)	LLTFWEKLRLAPYSPPKNINY
 1252- 1272 (39.04/32.39)	LSTVYDTCLLGSHYPAKIGNY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     219.72|      56|      61|     471|     529|       6
---------------------------------------------------------------------------
  425-  463 (54.26/29.80)	.....MGPK.EIVMSNIFEVLSTSD...........GCSSQELL....KKAL...AEPVLSSP
  471-  529 (84.12/60.32)	ATPTSLGPKAESVSNDMAEDMEDTDsrISESFeNYTGISLKEFA....TTFFLENANQMLAPN
  534-  591 (81.34/48.51)	ADHKSTTPNSE..DNTRGEYIQGLE..ISQNI.DINGFNISESAgrnmPTQPLLQTNEIIASN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.08|      28|      38|     284|     311|       7
---------------------------------------------------------------------------
  284-  311 (46.76/28.55)	KIAPQQDISQQLETNVLLQWSLLFSIPV
  324-  351 (45.32/27.44)	QVIPQLTTILTLRNELVLYPTALIFVPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.57|      18|      40|     363|     382|       9
---------------------------------------------------------------------------
  363-  382 (26.10/22.82)	MNSTlRYNQ...GYTEDLgEKWS
  403-  423 (30.48/16.47)	MVSD.EYGQridGLRRHI.NYWS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.34|      14|      16|     770|     783|      10
---------------------------------------------------------------------------
  770-  783 (25.29/16.03)	IDS.SILME..NTAGGH
  786-  802 (17.06/ 8.32)	LDSeDTLMTdvDTMDNH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07451 with Med13 domain of Kingdom Fungi
Unable to open file!