<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07450

Description RNA polymerase II mediator complex component Srb8
SequenceMSSRNPKGAQQRAQQRAPTGSALQAHQRSISSSHIPPPSPVRRDGLPDHSQPTDPADTSSQAGTAGRHGATPRRTAGSKLRIELSNDDSLTPGPVTDSPQGTPSVMSHSAGFDSSADVSGHGSPALSRASQSDLSIPRMPMPRRRAPLQRFVPSNKTAAPPTAPIKRDSKPKQYTIEVPAAAPRYLTTNKPDTLHRDPFNKGLFSGHADFFPWTGRHHEDEWSTEAIQKGTWDRGSQNETSSARLAVYPSLKQKTGLNALSTIFMGVLNQRRNRGQITAPSTFKPPPRVTLTDTKREVWLKDLANPTISLRRLSRTIPHGIRGRTLLDQCLNKNVPTERAVWLAKCVGANEIRAFKRKGVTGALVMGNELKWIRDWTIFVEQFVDSVVSSVGEPDWKHRVTYSIRLATVLYSEHLLDRDHYLDWIVSGLENSSQAKLPMWILIAQICWTDILRSRKPGRRLVFALLNHLNTIYNDPDRDILIPLSNQLVSLLKSLVAKNPESFIQPLQWLKYRDCLSAFLSTDERAIQQALRSINHRNSELLVSTAASPPVGGKEHLVKLLDTTLHGKVDHDLSSKCWAISEDKTQILKTVIEWVTSFHRPGLEKIYTATNLLRSWASFRVNTTGAILDTLDSIEPDDEVRKQAVYRLVIELARTGHFSVSQYIQWLIARGNCHNAADVEETGPCASRLLVELPVSCIPEDRKMDRANLLRRAAHYDVADEARDISTAIKCVNQTIGLPLPNVDDYAALPSKPLPLRKLVNRISVSSFALKSAVGVHLCNEFRNLLPPRLDTDVSLNVFTSSRTILESTKDFSMLGEVLKSCSKMSNIEVLAVCVDTINVNLEVLLAVGIADELFALYFERLKAASREHGLVARPLLAALSSLAQRMPNQSVMAKNLQQELTQTDRTNPIDACSPVSDNMVSQATSPEGEFSEQIDKLLATGNSVDHPTMNRLFLNIVPRLEAGWNKLDASRRVYASLLARLRIFDSQHFDKLMSDWVSHIRSLKERPALLELLPLLVSLGCLTMVTVLHTANAAPVAANVTAVDSGPPRGSAIYLQELLQLILRKLPKQSPLTAEESYRFVVYQQAAKIEHSKALLLLIRNAVQEYSILRSRSTTTALPLDDRTCQDDVLEALRVLVVTNSTAAAEALSMKDLAPDASALIRTVAAKLLTPGDENRSSSFDKILGLANELTMPFCQLSLSMELSLPQDNRIAGNEPQESQFDVFARAMDSAIEARNILWTSMLPCLSDDITQHLRSQAHGRFLKMIPSSKATNFAELATSEDRIQLAKNLLGVIEAIISAQPPSKSAQLTTTLVDKLTDLWEIVSVREASAAQDAIRKHWLPFLLRFITLHSIYSSSASDTSTATASTATPGSSAVNKAVSNVVAPAASATTTANSNHEARARIVLVLCGILFALESQQTLPPDGKLAQQVFDIALLLVDALPDDMRLHCARNVLANPSAVPSSGTSATSRSGTSDPRIYYLFSAPRPTAADNLMLAHRERGSIPLSAAARGLGAMYGIGPTLQERYSHFALRRWEALSEPTPNVGENDTSLSLGLFEAIKIQ
Length1564
PositionKinase
OrganismCordyceps fumosorosea ARSEF 2679
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Cordyceps.
Aromaticity0.06
Grand average of hydropathy-0.213
Instability index45.73
Isoelectric point8.91
Molecular weight172026.33
Publications
PubMed=27071652

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP07450
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     179.70|      45|      52|      38|      82|       1
---------------------------------------------------------------------------
    2-   58 (66.08/40.24)	SSRNPKGAQQRAQQRAPTGSALQA.............hqrsissshippPSPVRRDGLPDHSQPTDPADT
   59-  112 (66.91/40.85)	SSQAGTAGRHGATPRRTAGSKLRI................elsnddsltPGPVTDSPQGTPSVMSHSAGF
  113-  180 (46.71/25.77)	DSSADVSGHGSPALSRASQSDLSIprmpmprrraplqrfvpsnktaappTAPIKRDSKPKQYTIEVPA..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     275.09|      70|     123|    1268|    1337|       2
---------------------------------------------------------------------------
 1268- 1337 (111.09/75.67)	PSSKATNFAELATSEDRI...............QLAKNLLGVIEAIISAQ..PP.SKSAQ....LTTTLVDKLTDL....WEIVSVREASAAQDAI
 1387- 1462 (93.73/62.46)	PAASATTTAN.SNHEARA...............RIVLVLCGILFALESQQtlPPdGKLAQqvfdIALLLVDALPDD....MRLHCARNVLANPSAV
 1463- 1540 (70.27/44.61)	PSSGTSATSRSGTSDPRIyylfsaprptaadnlMLAHRERGSIPLSAAAR..GL.GAMYG....IGPTLQERYSHFalrrWEALS...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.81|      51|     123|    1007|    1129|       3
---------------------------------------------------------------------------
 1011- 1062 (79.71/121.92)	LELLPLLVSLGCLTMVTVLHTANAAPVAA....NVTA..VDSGPPRGSAIYlQELLQL
 1131- 1187 (70.11/13.15)	LEALRVLVVTNSTAAAEALSMKDLAPDASalirTVAAklLTPGDENRSSSF.DKILGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.99|      52|     510|     680|     736|       7
---------------------------------------------------------------------------
  680-  736 (81.38/59.45)	EETGP.CASRLLVELpvsCIPEDRKM.......DRANLLRRAahYDVADEARDI..STAIKCVNQTI
 1190- 1251 (76.61/43.31)	ELTMPfCQLSLSMEL...SLPQDNRIagnepqeSQFDVFARA..MDSAIEARNIlwTSMLPCLSDDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.04|      32|     118|     967|    1007|      12
---------------------------------------------------------------------------
  459-  495 (41.03/13.63)	RRlVFA.LLNHLNtIYNDPDRDILIplsNQLVSLLKSL
  972- 1004 (54.01/44.36)	RR.VYAsLLARLR.IFDSQHFDKLM...SDWVSHIRSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07450 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSSRNPKGAQQRAQQRAPTGSALQAHQRSISSSHIPPPSPVRRDGLPDHSQPTDPADTSSQAGTAGRHGATPRRTAGSKLRIELSNDDSLTPGPVTDSPQGTPSVMSHSAGFDSSADVSGHGSPALSRASQSDLSIPRMPMPRRRAPLQRFVPSNKTAAPPTAPIKRDSKPKQYTIEVPAAAPRYLTTNKPDTLHRDPF
1
199










Molecular Recognition Features






MoRF SequenceStartStop




1) AQQRAQQRAPTGSALQAHQ
2) KLRIEL
3) RDSKPKQYTIE
4) RIYYLF
9
79
167
1479
27
84
177
1484