<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07448

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMTSGGDGPPLSMRPFPVADKSPKNLSELIARVNALPGGFRAVTETNLEEEIGEAANGEDGTQDVDMSDDADDDEDEEDAEAKDPQALRAEVLRNIDVASNTAMLTLDSLSLLLSKQNPTQAGLTLSQQLRDMVGIGTMGADRLTDDDAPTAPAAKTTDRAAVALGWTLMEIDAARDAAEDATAFLAAEMAAEGRYWEGVMAVRQAGWSVCRVPREPPGTLGVRFGFSEAAPEFQRLGLAPLRRGDEDGAARLDISRLGGTQERLVVTYERGGKVVGRAAPRELTDAYGDDEDEEQDLETRVLGARNTIFAQELWHELTREARSLAAYDVRAEGEKRLVCAVAGDDDGDDARIVVELLPVSACQSPEAPDEPLPEDVTAQAISLALHILLTYAHRCGEMLRTRPFPPHVPRARGQQQMVHTLLRPVVARLTYARAATSCTRLVGSLVRTLRSAGLSSASFTLRTPQPTLAAELPPGTPAAVALVRAMLQPTDFALEVALLPGVDFAVRGRTYLVPVTATYYHVLAPADATIHALCAPYADGYPDVAALADYLGTLAGRALAAHHMARLGGGTAGLDGPPRQLDFAVACGKGGARQPLQLTVRSARPSSSGGARSWTWTPDAETSAKETLEAVVDNVLKR
Length638
PositionHead
OrganismCordyceps fumosorosea ARSEF 2679
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Cordyceps.
Aromaticity0.05
Grand average of hydropathy-0.223
Instability index45.17
Isoelectric point4.78
Molecular weight67960.62
Publications
PubMed=27071652

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07448
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.06|      29|      38|     389|     424|       1
---------------------------------------------------------------------------
  389-  424 (48.40/43.41)	LTYAH...RC....GEMLRTrpfpphvPRARGQQQMVHTLLRP
  429-  464 (38.66/19.85)	LTYARaatSCtrlvGSLVRT.......LRSAGLSSASFTLRTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.34|      14|      17|     225|     241|       2
---------------------------------------------------------------------------
  225-  241 (18.69/19.91)	GFSEAApefQRLGLAPL
  244-  257 (23.65/13.56)	GDEDGA...ARLDISRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.79|      22|      38|     281|     303|       3
---------------------------------------------------------------------------
  281-  303 (32.99/26.18)	RELTdAYGDDEDEEQDLETRVLG
  322-  343 (36.80/23.95)	RSLA.AYDVRAEGEKRLVCAVAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.08|      42|     566|       2|      45|       6
---------------------------------------------------------------------------
    2-   45 (69.14/44.09)	TSGGDGPPLSMrPFPVA.....DKSPKNLSELIARVNAlPGGFRAVTET
  571-  617 (72.94/38.84)	TAGLDGPPRQL.DFAVAcgkggARQPLQLTVRSARPSS.SGGARSWTWT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.53|      32|      45|     477|     509|       9
---------------------------------------------------------------------------
  477-  509 (50.53/27.19)	PAAvALVRAMLQP.TDFALEVALLPGVDFAVRGR
  525-  557 (53.00/25.14)	PAD.ATIHALCAPyADGYPDVAALADYLGTLAGR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07448 with Med17 domain of Kingdom Fungi
Unable to open file!