<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07446

Description RNA polymerase 2 mediator complex component
SequenceMASEARPARPAVTPAPVLRRTNSTQQAPPPLPPPPPPPQQQQQQQQQQQQRIEKPTPQKLLQQRLHQQQFQKQQQLQQLQKKLQKKQQFQQLPQTQQQGPQGKRPQQQQQQQQPSSSSSSARKQQQRPGHGQHHKTRQKQPVQRPLPPGLYQAKPKAHVSSSRTNATTDVPSEQQAPSSVDATPKATGRAKPDLPLCSNRGRATFAEFTWASDPLGKDGDGAAGAPSASASATSSTTVAISSPTATTGSNGGSLRASIFKKSTSLVYGASSTPGQRDADGIDKDGRPRPWRPEVPSNVPYYFVPPPGRRFGGLAKAGPRGYAQSPAQAPPGGHGPAGRSASGNSMGAYGTAGFGNARSNSSSSSGGGGGGGGGGGNNMQARNSGSANTAANNRVQQKAPVVKYADFYPWKGRHPEDRFTEATVRGGHYDRLQNSQSHNAETSSARGWLPMLLKQKHSIAMLGQALALANALSREKNHIAPASQFKLPPRVTVTDTRRETWLRDLTNSAIPLRKLSRTIPHGLRGRVLLEQCMLKCVPVDRAMWLARCVGAQELRAFKRKGTASVITLAESELRWLKDWTLTVQQFLEAFLAEFDLDKDTGRDRLLYAVRFARQLYLERLVDHDQFLNWMLAGLRGAARLPAAVSPVPYFDLWLVVVEEYFHDLMQRRKTSSHLALSQFRTAPVSSAQAKKLLERMVQGHPDAFVCQAVWPRYEKIIADLSLSPASASSETSPHAPLLAVSTIRHRNDCLRPEMPAEMEQVAHKLLPLDSFVRRPVDFDSHFADFLRLDRKEAVPFVIRWCASIHRLGLARVYVAGRLIRELCRDDAKLATDFVLAFLQSNLKDKDNGDTASAAARTLAPVTEGNHHNKAASKERQQQSRQFQDKQSEGSKAFYQLVGHLVLHGAFMPAQYLAWLILQSRPSDADSVVSDGQPHVRLVAELPVHLLDHHIGSLRANHLRRLGYDTDLEAKDLAAILRDVQASINVPPTTSATAKPAEARPSGRVLASVLRRIQSRSRNVKMAVADWLEKHVVSPLGAYEASGKAGAIPPAKPGIRSAPSKQIASADEKGATNHPANMPLDRVDAIRALVESTDDLKLLAAFMLALVSCPQSISVMALCADTVNLYLPAFLALGDGRLLYDRIMDRALSMTVALDAGATTAFQTLLPAGTDLRPLILALPALAEKMPPPKPGTLVFGVNMQASRWIPTNAGKQSKVPSAVDGDIAGERHYDAGSAMGSEVYTRLLDLDRRLSIATYDADCSPLSDGRGPPASQEDAAVDEVRDEMAKLASSGTSIDSTTMDRLFGTIAMISQERWRLLMPESSGGGGGGGGGGSARAGAGAGAGNDDSEPARRDRARDNLRLSASLFARLRRFNTIHFDTIMIKWLKRLRTMRNRPPIRTVYPVYVVLGCLDLASLMATTADEQAREPGAMQQSPARNTWRTAYLQDVLALLSAPLADGHPMLTCDEVQRFRLFQSEAPLLAPAGLAALVRNAVAEMTLWRHHQRRDGQGSIVATPSAAAAAVAASAATTTRTTTAAAATAPAAAAATAASRAPIDARCVSRLLRAVAVADAPAAAHALAKTTDQTVRSGLWEMTTLALTGRVLPARTPLAMLRGLDVFAAGVGQLALGLVVGPGPYASVTERAKDADHLTNLILRAVSEFRFSSLHVLHSLPADMAASLKDHAQARFLDLVPTRKLLTASAPVVGLGIGMNTDAATDTVPNFAVASGFLDIVRAIMLNQQQQQQQQQKLQLQVQQDTTAAAAAAAAAAASAFGNASLTSIPPPSSPGLLPTPVAPPLDASVVDKLGELWCLLREPTGLPAQRDAQSSSDEPARIHSVKQAVLRDWLPALLSLIMLHLPNRDAVALGSDERQQQKQQLAASSTVRAGVGSVADTKGAAALSSTTFKRANMNATASNSAVGLLGLPRSARDLEQEAVHAGACIALASLSMEVPSWAGDDEGDSDQNEDKGNGSSRINNADGSSAQCLTLQSRLFDAALLLADGLSDETRQHCVRALRDAVAGAGASTSVGANAHVKANTIAAGGDLPPILAYMLSCTAAGPVDYPRLYLERVPPTLFSRAAPSQPTTTTTTTTTTTTTREVSQEGGGRTPTPTPTPNSTPTPGTPGPGQLKRMAASMGFGGVLGNERNKRVRFGLKTWDAVSDPTPAVQDNDTAVNLWLLEATKVVRQRRR
Length2188
PositionKinase
OrganismSporothrix insectorum RCEF 264
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Ophiostomatales> Ophiostomataceae> Sporothrix.
Aromaticity0.05
Grand average of hydropathy-0.341
Instability index52.94
Isoelectric point9.73
Molecular weight234437.97
Publications
PubMed=27071652

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07446
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     268.78|      65|      75|     384|     454|       1
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  320-  372 (86.60/37.89)	GYAQSPA.....QAPP....GGHGP.AGRSASGNSMGAYGTAGFGNA.RSNSSSSSGGGGGG.....GG.....
  384-  451 (101.52/57.47)	GSANTAANNRVQQKAPVVKYADFYPwKGRHPEDRFTEATVRGGHYDR.LQNSQSHNAETSSA.....RGwlPML
  462-  527 (80.67/37.09)	GQALALANALSREKNHIAPASQF.....KLP.PRVTVTDTRRETWLRdLTNSAIPLRKLSRTiphglRG..RVL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     516.36|     124|     129|    1733|    1861|       2
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  222-  286 (61.59/22.09)	............................AAGAPSASASATSSTTVAI........SSPTATTGS.NGGSLRASIFKKST...SLVYGASSTPGQR.DA..DGiD..KDGR...............................
 1516- 1571 (42.93/12.62)	...........................AAAAAVAASAATTTRTTTAAAAT...APAAAAATAAS.RA.PIDARCVSRLLRAVAVADAP.....................................................
 1733- 1861 (198.47/101.61)	AIMLNQQQQQQQQQKLQLQVQQ..DTTAAAAAAAAAAASAFGNASLTSIP...PPSSPGLLPTP.VAPPLDASVVDKLGELWCLLREPTGLPAQR.DAQSSS.D..EPARIHSVKQAVlRDWLPALlsliMLHLPNR..DA
 1863- 1993 (159.66/72.87)	ALGSDERQQQKQQLAASSTVRAgvGSVADTKGAAALSSTTFKRANMNATA...SNSAVGLLGLPrSARDLEQEAVHA.GACIALASLSMEVPSWAgDDEGDS.DqnEDKGNGSSRINN.ADGSSAQ....CLTLQSRlfDA
 1994- 2060 (53.70/18.09)	ALLLADGLSDETRQHC.VRALR..DAVAGAGASTSVGANAHVKANTIAAGgdlPPILAYMLSCT.AAGPVD......................................................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     102.79|      20|      20|      31|      50|       3
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   11-   32 (22.05/ 8.05)	AVTPAP......VLRRTNSTQQAP.........ppLP
   33-   53 (36.04/18.58)	PPPPPP......QQQQQQQQQQQQ..........rIE
   54-   80 (24.21/ 9.68)	KPTPQKllqqrlHQQQFQKQQQLQ..........qLQ
  117-  147 (20.50/ 6.88)	SSSSAR......KQQQRPGHGQHHktrqkqpvqrpLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.93|      21|      50|     990|    1013|       4
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  990- 1013 (27.12/22.98)	ATAKPaEARPSGRVLASvlRRIQS
 1043- 1063 (37.81/20.61)	AGAIP.PAKPGIRSAPS..KQIAS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.31|      30|      43|    1393|    1424|       6
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 1393- 1424 (45.26/40.15)	RPPIRTVYpVYVVLGCLDlASLMAT....TADEQAR
 1435- 1468 (49.05/32.42)	RNTWRTAY.LQDVLALLS.APLADGhpmlTCDEVQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.92|      34|     129|     941|     984|       7
---------------------------------------------------------------------------
  941-  984 (43.56/60.15)	PvhlLDhhigslRANHLRRLGYDTDlEAKDLAAI...LRDVQASINV
 1077- 1113 (53.36/37.90)	P...LD......RVDAIRALVESTD.DLKLLAAFmlaLVSCPQSISV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.32|      22|      42|      94|     116|       8
---------------------------------------------------------------------------
   94-  116 (39.52/25.46)	QTQQQGPQgKRP.....QQQQ..................QQQQPSS
  135-  179 (21.79/ 7.77)	KTRQKQPV.QRPlppglYQAKpkahvsssrtnattdvpsEQQAPSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.73|      12|      17|     764|     777|       9
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  764-  777 (17.25/20.13)	LLPLDSfvRRPVDF
  784-  795 (21.48/15.03)	FLRLDR..KEAVPF
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.33|      30|      44|     673|     705|      14
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  673-  705 (45.71/35.72)	LALSQFRTAPVSSAQAKKLLERMVQGHPDafvC
  719-  748 (50.62/31.23)	LSLSPASASSETSPHAPLLAVSTIRHRND...C
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07446 with Med12 domain of Kingdom Fungi
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