<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07437

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMTTAEDMPMMLDTAMSVGLGGVDDLFGDEVPLSLPPKTQGRHLHQRLDDLRNRGCCQTIAWSRAGTIASITPDGLSLELRMLRAHPANGSWGMSEPTTTDLVKGTVTNPLVHLEWSTTTAPDLAIFDSTGRVMIMNFPVSLNAPFANRKWDADTVDDMNAIVGCHWLPVPPISQKTFNVLYGPAIKAQPNSPYHYENSFVQAMGPHHPHTSKSALFCVTMSGLLKMYWSQNNGRMEETTMELESICSSDELVTHASLATDKRYLIIVFTTATKKLKVVKLEIQWAGPGAVQEKTQLSLTARLNPSLVEDHLASIDWLQMVDEPSLPEFTSLQALPSIVASIGTPGPPLIIGARARSSGIGGFEMMQTIIDRWECVEQKPAIQKAFEQMRSRRNSVSTTQELPVLTRLKRLDPITINKTVISMQVSQYGKVLILVMSDGSVEHRDRFTFEELYTTTDDSRISSLTAAGWTFAEDGPCYQAAFSPTQCSIIQTGDDGKLSWRKLQYAQGDIGESNNDSAYSATVAGLAIATAPCIMTQSNFDDLLAIAHPLAEKKRLASDWIQELIKLLKVQIDYTQESHHESLMRNTSLQFCMSIMNSLGFKGENAPRTSQGKFAYIFLNVRIIVVLATLASNTPPQARDKMSPLDEPEVVEALAGELKWGMDLLAWIMDCLFELSNDEQFMQNLNGKLSAASEYLQERNDVALHLLLSSPTRSFLLALCRRISHLDGVSARTLEFYRQQAAEAERSGVARLSSGQLQQAYQRMQQVTSSSLVPVAEFEKMLNTLNHDINQVYAVYLPALLRQASHPPQGKQIDMRIKSSQAQMEVVMLLSRHVPPAFMALVRKLFVEDLGPVRAQLDPAALFFADFTALGVQDDNASLAARAARNGGGPYYDSFKRVELQRGTRGQKPWRRCVRCPTLMEDVSPNRPGVTYVLAPQRKCSCGGSWGLLAKDKMVL
Length955
PositionTail
OrganismBeauveria brongniartii RCEF 3172
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Beauveria> Beauveria brongniartii.
Aromaticity0.07
Grand average of hydropathy-0.181
Instability index40.38
Isoelectric point6.17
Molecular weight105782.07
Publications
PubMed=27071652

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07437
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.02|      33|     119|     541|     576|       1
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  541-  576 (52.29/43.07)	DLLA.IAHPLAEkkrLASD..WIQELIKLLKVQIDYTQE
  662-  697 (49.73/32.77)	DLLAwIMDCLFE...LSNDeqFMQNLNGKLSAASEYLQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.24|      43|      55|     437|     481|       2
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  437-  481 (70.64/58.50)	DGSVEHRD.RFTFEELYTTTDDSRISSlTAAGWTFAeDGPCY..QAAF
  494-  539 (67.59/46.46)	DGKLSWRKlQYAQGDIGESNNDSAYSA.TVAGLAIA.TAPCImtQSNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.29|      22|     256|     324|     345|       3
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  324-  345 (39.88/25.94)	SLPEFTSLQALPSIVASIGTPG
  581-  602 (42.41/28.06)	SLMRNTSLQFCMSIMNSLGFKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.22|      44|      60|     769|     813|       4
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  769-  813 (73.66/56.55)	SSLVPVAeFEKMLNTL.NHDINQVYAVYLPALLRQASHPPQGKQID
  830-  874 (72.56/50.79)	SRHVPPA.FMALVRKLfVEDLGPVRAQLDPAALFFADFTALGVQDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.15|      28|     851|      52|      93|       5
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   66-   93 (53.16/55.55)	TIASITP....DGLS.L.ELRMLRAHPANGSWGM
  628-  661 (36.99/13.32)	TLASNTPpqarDKMSpLdEPEVVEALAGELKWGM
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07437 with Med16 domain of Kingdom Fungi
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