<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07435

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDSQPSAARGALQEAVKYWSAFVARCIAQRLDSNRFQDFVQLVHARHPLPPVLVADLFLRPQPSNRVSLDPRIPPYVRILAQLRYVDAPSILRVLYKYSALHAHDRLPLPLPSLPENGGDGETMKKEEEEEEEGEEKGAGGGGVMRRDKMVRWQESAWAEEVLFYHVIKTMFEGTAFTDAKTGLELVDITCKWMDLFVHASSELAADMLANKHDRQARDEMETSTGIRKHLSESLGNFIQTVQPPPLYIERLEIFRTQTLAQLDPIDEKKKAANAAMEELLDSTVGSDNFVVPEILISNSRAALYVYLNAALVARPVLDDSMLYAFLNNKYQENQQASAVDLIVASFDVLANAVFRNEGPRDAHLLRSFVVNKLPLLLCQLCHPEFSAASAEFCITEALSRVDTGIFPTASLMFDESRNNNPYMDSVREEFCAACALHGLIERDHVDRILGETSMSYDPSLERANRDRLVNDCLSDSGRIQNIISQLDRVDGNVGAVAHAIVELIRQLCNNKDTTSLKLLCTQLSQKPQSLDIILLFDKVTSVLEPVCTLLDNWKYEEDQGEYQPVYEEYGAILLLVFAFTYRYSLSPLDIGIQSVDSHVAKIIAKSHILRPLEDLNEQEAEHVAGWITGLFDNETGGLGDDLMSSCPPHEFYLLVAPIFQSIITAYTYGYINDESLKGGVEYLVDTFLLPSLVPAIRFLSDYIWIDEKEQKSIVKALQLLLTPSSISGEASTVLSAVKNLIAQPLEHALRTYQRQDPRNQDIEPLLRSLKENLPLSRRTGGPEHHEMVSWANNSNSGLSGAIRHTIQGLVQWSLQPGVNVMPTSYTHRQLITGLRIIGPSRLLRLIMEEIRQQSELGNASVVYDVAAALIAATDPTNEAPPGPNLLDTAGTMQATPPPLRPQGLREALKTAAEGCKRLQKHDQFLAEATVRLHRRVEMLLVVPQPQAMLQTTDMPLDLGGDAMAAAAAAAQAVGAADPMSVDGLDTTGLDTTGLDLGMGADMGLSGGGSDGDLFGGLDTSLDMFDGWDSMDMGVN
Length1036
PositionTail
OrganismBeauveria brongniartii RCEF 3172
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Beauveria> Beauveria brongniartii.
Aromaticity0.07
Grand average of hydropathy-0.157
Instability index45.78
Isoelectric point4.85
Molecular weight114416.74
Publications
PubMed=27071652

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07435
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.68|      13|      18|     116|     128|       1
---------------------------------------------------------------------------
  116-  128 (23.76/15.43)	ENG.GDGETMKKEE
  136-  149 (19.92/11.72)	EKGaGGGGVMRRDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.47|      18|      20|     980|     999|       4
---------------------------------------------------------------------------
  980-  997 (31.45/15.23)	MSVDGLDTTGLDTTGLDL
 1003- 1019 (25.48/13.84)	MGLSGGGSDGDLFGGLD.
 1020- 1033 (27.54/11.82)	TSLDMFD..GWDS..MDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     220.35|      73|     231|     256|     335|       5
---------------------------------------------------------------------------
  260-  335 (109.89/95.64)	LAQLDPIDEKKKAANAAMEELLDSTVGSDNFVVPEIL...ISNSRAALYVYLNAALVArPVLDDsmLYAFLNN.KYQENQ
  484-  560 (110.46/74.36)	ISQLDRVDGNVGAVAHAIVELIRQLCNNKDTTSLKLLctqLSQKPQSLDIILLFDKVT.SVLEP..VCTLLDNwKYEEDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.74|      28|      35|     392|     425|       7
---------------------------------------------------------------------------
  392-  420 (47.40/45.55)	EFCITEAL......SRVDTgIFPTASLMFDES..RNN
  430-  465 (42.34/21.90)	EFCAACALhglierDHVDR.ILGETSMSYDPSleRAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.79|      19|      19|     773|     791|       8
---------------------------------------------------------------------------
  773-  791 (36.96/23.30)	NLPLSRRTGGPEH..HEMVSW
  793-  813 (29.83/17.40)	NNSNSGLSGAIRHtiQGLVQW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.53|      32|     400|     338|     369|      10
---------------------------------------------------------------------------
  338-  369 (53.72/30.40)	SAVDLIVASFDVLANAVFRNEGPRDAH...LLRSF
  736-  770 (49.81/27.70)	SAVKNLIAQPLEHALRTYQRQDPRNQDiepLLRSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07435 with Med5 domain of Kingdom Fungi
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