<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07432

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMENGDGSGRTDHDRLSSNVKDVVDQRAAPDDKGKAKASGNPSDPPRMNDLPDEITHITQGFIQLSAFLTRLAQVTHNSLQEKVVELSKMPIPASALNGGATNLTSSAPDDTSAENLRKKATLLHFAQDMHAKWVKALVITEWSRRANMVSKLIDLKFHMDQLRVHYDMCLDNMVNVKRDLTYARMPAPDLKTALQVLSTGSAPWIPDFRNYEIGSGRVTFKVPDEFEVELTIADEDTDKQFWFIDFRYAFTPSALSLSEGLRNYLENYVNDALARNGLAGCYQFLHEMVLTAKITELKRQALRLSRTSWDGTLVVEPLNRALAIQYWSSRSTTTKSWVLIAINSGKKNGKVDEKTPSHLVVKWYRDNKEVKDVKLALNVGTLSAESLLKEVIGRHIGYILQNIRDKFLEAPRFKQHEAAMNLRISNTNPGDCMLTTQVSHNATTTLLVEPTTGIFAVKPQSKFSIPYEHQLNSGKNSTDDGAACLENVRCAMMEDELHRRGNTVGWQTQKMPLSVEEVKSVTKMRDWTRTIWMRKQGWGESWYMAIFLGLGGDEWWLLEVNRNEPGRTVKFQARLPLSKGHPDFSTAFWGNLAIFVTGMIAQAVDMRELHRLRIKSRTNDSINLALPQQLQLPSIQVALSAMFPSIVHDGGSKSEYRQPWANDVVTIRFTCIESTDDSLTCLSEAVLRVRKPSKFAALKGTVDGNLLYNAKLGEFCLRVQHAVGEPVLALLKSRIKAIDRFVNFLEAMDKSKGSIVGELVTLKEIRFLYYQAGSIGSESKQQWRITLDLSRDDIAIKIERGNPHLRVVDLMQQLVNSDGGIGALMRWLPASLRALEAVSSIETRWEEMQLKRLGLVDFAMKTLSWLSLQYTIIVAGPSPTKRVILLQVRTQTRRGEAWWHVWRSHDGVAPTESDDDDAYAAALRSVWNGRGPGWIGLSTGAAARCESGVVGMLLAVDDAVRSVVVDDSSTAVPTQSSTNPSFTQRTSQSLNSGKDVVVLE
Length1000
PositionTail
OrganismBeauveria brongniartii RCEF 3172
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Beauveria> Beauveria brongniartii.
Aromaticity0.07
Grand average of hydropathy-0.296
Instability index35.49
Isoelectric point8.57
Molecular weight111843.38
Publications
PubMed=27071652

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP07432
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     253.05|      80|     204|      71|     271|       1
---------------------------------------------------------------------------
  183-  271 (130.38/253.59)	ARMP....APDLKTA....LQVLSTGSAPWIPDFRnyEIGSGRVTFKVPDEFEVELtiadedtDKQFWFIDFRYAFT...PSALSLSEGLRNYLENYVND
  573-  663 (122.66/44.80)	ARLPlskgHPDFSTAfwgnLAIFVTGMIAQAVDMR..ELHRLRIKSRTNDSINLAL.......PQQLQLPSIQVALSamfPSIVHDGGSKSEYRQPWAND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.51|      12|     198|     476|     487|       2
---------------------------------------------------------------------------
  476-  487 (22.66/14.76)	NSTDDGAACLEN
  673-  684 (21.84/13.96)	ESTDDSLTCLSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     210.51|      55|     198|     296|     353|       3
---------------------------------------------------------------------------
  296-  353 (84.52/64.10)	ELKRQALRLSRTSWDGTLVVEPLN.....RALAIQYWSSRSTTTKSWVLiAINSGKKNGkvDE
  445-  475 (34.30/16.75)	................TLLVEPTT.....GIFAVKPQSKFSIPYEH....QLNSGK.......
  496-  554 (91.70/59.18)	ELHRRGNTVGWQTQKMPLSVEEVKsvtkmRDWTRTIWMRKQGWGESWYM.AIFLG.LGG..DE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.18|      17|      17|     833|     849|       6
---------------------------------------------------------------------------
  833-  849 (28.57/15.97)	RALEAVS.SIET.RWEEMQ
  851-  869 (19.61/ 8.77)	KRLGLVDfAMKTlSWLSLQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07432 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MENGDGSGRTDHDRLSSNVKDVVDQRAAPDDKGKAKASGNPSDPPRMNDLPDEI
1
54










Molecular Recognition Features






MoRF SequenceStartStop




NANANA