<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07429

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTSEYDTNTLLNNNISSIVYRIYEPSQEQAQTFPSAAADVETELRNCGHIVYYDATRRVLWYFYVPSKDAASGDESDGFLGNSVSVADATLLMADEGSFEPVSLFKGRAPGQQSVNTPTSSSSSNSTLDLSLRNPQTGTAGPPSSSDLEPKGTGSVALPDAYEQFITAVLSTISAAFCSRVSAIPLNHRTVLLPSKVTRDGQAERALDTESAVVGTFRIYLTTTGALFMSLSLSCCEGLLSVNEPSTPSQLVLGSQILAAPFGVLANYQGFVGGGLSYPELGLGQTPDTQLWRSADARSSQWRETCIKLLQSRGLSPTLLQSCPWIALQMLRRKSGEHKIDGKMTSIPSTLATISWPAVLCFRKKSVMLARNNGLGDSVLLAQDETSDFLNDARTWFQLGADRDEKVSKRKKEREIAASKEAATAAPPQQANGHSPLGLRRASNAAAAGTMYPTPPDGVQNPLGITPSMDGTTSSPGAPGTTMAVVDIDTTMADTGTHDTSTMNTNHHNEAYGGGWHSSDGKRDRADSFLAGDNDNLFGDIGPDMFGDTDITDADFSFFDEEGGDDLDLSGLPDLSMPDATSAPTMVPVPVPEPVKVVVPAVEEAKPVKSPPIFAKPELKHARSTLLDEGKQRFNAEKAAGVKRESSPFDPDTVYKRVRASLADIRSIPQRTPARKGSIFDSVDFDPVLPLVNKKYEQGGRFDCPPIFQGQSQDTSTQPASQGPPTTDYLRRHGKQRKALRQPEYTNALIRTITGNLENSSLIVSPGKGDELASDADDISLVSDQDDSSVSEDEPTSPFKSSIRRLNLEDDVASHVTSLRDIESVDDSDPALALDLPKLARAEASEILIPKYFEDAESLPIYLSLPDEDTITIAQIVTEQAVTGSLRIRDALANTLNTAIVSDTRRQLSSLGRTALQALREVIPTSLGEFNTCNFKGFVEVPDVPLIGPPSRLHPRPINPRENTEPPKPNNLFQIPAPHMELRRAESRLSVLPASVQFWESLGLGPAQGTKDVNVVCVFPHWDGMSDVAAAFLDRMRNVYELLKLGSFERLPSSSKVADGLVPFEADKIATSPGTVSPHIVAGLSDRMEALNQGLISANATEKNFVIYFVYPPDHPGSIVEACTAFQQLFEMHRRSLTDRRQTPTNELVLQLVPLDFLTSSTGMVEPTPSDAMKLAIETYDRCTLFGGPMPSPAIMLEQSLPRGIDFKLSNTSSSSLMHENTCIHIAYAQSIDERWITAAWTDNRGCQQMTASYNLGRKGKPLSTSLNDVCHEIWETTHDLISKWKVHWRVVISKCGFMDAQEIGFWQGLAQTESVATVSLTLISVDTNPSMQLLPPAIKVPATASSAFYTTPVSTPQASIVSPEQSGTPVTPMKENNPVNAATPGGTPGDGNAEPAEGDAILLDVTDQTWGAVLAHRLSNSSSLGELHPALISGYLVKRGGTKLEDPPVVMEVNIVHADNNPRMYEPLMREMLTYFRGLGTLARARGVIDRGTDVRPWHIAAAEKGVRALYLLM
Length1516
PositionKinase
OrganismColletotrichum incanum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum spaethianum species complex.
Aromaticity0.06
Grand average of hydropathy-0.303
Instability index46.57
Isoelectric point5.01
Molecular weight164104.57
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07429
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     328.96|     106|     500|       2|     119|       1
---------------------------------------------------------------------------
    6-  119 (163.53/115.81)	YDTNTlLNNNISSIVY....RIYEPSQEQAQTFpsAAADVETELRNCGHIVYYDA.TRRVLWYFYvpskDAASGDESDgFLG.NSVSVADATL..LMADEGSFEPVSLFKGRAPGQQSVNTP
  499-  612 (165.44/88.23)	HDTST.MNTNHHNEAYgggwHSSDGKRDRADSF..LAGDNDNLFGDIGPDMFGDTdITDADFSFF....DEEGGDDLD.LSGlPDLSMPDATSapTMVPVPVPEPVKVVVPAVEEAKPVKSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     333.69|      85|      89|     992|    1079|       2
---------------------------------------------------------------------------
  911-  979 (81.35/43.77)	..........SL..GRTALQALREViptslgefN.TC..NFK..GFVEVPDVP...L.............IGPPSRLhPRPINPRENTEPPKPNNLFQIP...AP
  992- 1079 (141.35/89.11)	VLPASVQFWESL..GLGPAQGTKDV........NVVC..VFP..HWDGMSDVAAAFLdrmRNVYELLK..LGSFERL.PSSSKVADGLVPFEADKIATSPGTVSP
 1081- 1168 (110.99/62.60)	IVAGLSDRMEALnqGLISANATEK.........NFVIyfVYPpdHPGSIVEACTAF....QQLFEMHRrsLTDRRQT.PTNELVLQ.LVPL..DFLTSSTGMVEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.66|      22|     496|     811|     838|       5
---------------------------------------------------------------------------
  653-  675 (33.42/ 8.29)	DTVYKRVrASLADIRSIPQRTPA
  811-  832 (39.23/21.14)	DDVASHV.TSLRDIESVDDSDPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.97|      46|     417|     262|     315|       6
---------------------------------------------------------------------------
  262-  315 (68.93/57.52)	PFGVLAN..YQGfvGGGLSYPELGLGQTPDTqlwrsADARSSQWRETcIKLLQSRG
  688-  735 (84.03/46.12)	PVLPLVNkkYEQ..GGRFDCPPIFQGQSQDT.....STQPASQGPPT.TDYLRRHG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.24|      14|      83|     152|     167|       8
---------------------------------------------------------------------------
  138-  151 (24.64/16.93)	TGTAGPPSSSDLEP
  154-  167 (23.61/ 8.23)	TGSVALPDAYEQFI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07429 with Med13 domain of Kingdom Fungi
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