<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07428

Description RNA polymerase II mediator complex component Srb8
SequenceMSSRNSMGVPQRAQQRALTGSALHAHQRSISSSHIQPHSPVRKDAFADHNQPTDPSDVATASSQATTASRHGATPRRAAGSKLRIELSNDDNMTPGPATDSPLATPSIASHSAAPDSSTDVSGHGSPALSRASHADSAIPRMPMPQRRGPLQRFVASSKTPAPPTAPLKRDSKPKQYSIEVPLAAPRFLSTNKQDAVHRDPFNKGLFSGNADFFPWTGRHHEDEWSTEAIQKGTWDRGSQNETSSARLAVYPSLKQKTGLNALSTIFMGVLNQRRNRGQITAPSTFKPPPRVTLTDTKREVWLKDLANPTISLRRLSRTIPHGIRGRTLLDQCLNKNVPTERAVWLAKCVGANEIRAFKRKGVTGALVLGNELKWIRDWTIFIEQFVDAVVSSVGEPDWKQRVTYSIRLATVLYSEHLLDRDHYLDWIVSGLENSSQAKLPMWILIAQICWTDILRSRKSGRRLVFALLNHLNTIYNDLDRDILMPLSNQLASLLKTLVANNPESFIQPLQWLKYRESLSAFLPPDASELQQAYRSINQRNSELLVSSTASPPIGGKEHLIKLLDATLHGKVDRDLSPKCWSISEDKTQVLKTLIEWVTSFHRPGLEKIYTATNLLRSWGSFRINTTGAILDALDSIEPDDIVRKQAVYRLVTELARTGHFSISQYIQWLIARGNCHSAADVEDTGPCASRLLVELPVHCIPEDRKLDRANLLRRAANYDVADEARDIEIAIKCVSQTVGLPGHNIKHDDPTLPSKPIPLRKLLSRINSSSFALKSALGTHIRDAFQRLLPPRLDAEISLNVFTSTRTILETTRDFSMLGEVIRSCSKISNIEVLAACVDTINVNLQILLAVGIADDLFTLFVERLKAASREHGLVARPLLAALSSLAHRMPNQGGMAKNLQQELTQTDRSNPIDACSPVSDNMVSQSTSPEGEVSEQIDRLLATGNSVDHPTMNRLFRHIVPRLEAGWNKLDASRRVYASLLARLRIFDTQHFDKLMSDWVSHIRSLKERPALLELLPLLVSLGCLTMATVLHTANAAPVAANVNTIESGPPRGSAIYLEELLQLILRKLPKKSPLTADESYRFVVYQQSAKIEHSKALLLLIRNAVQEYSILRCRSSTTVPPLDDRSSQDDVLEALRVLVVTEPTAAAEALSIKDLAPEASALIRAIAAKLLSPGDENTSSSFDKILGLANELTMPFCQLSLSMELSLPQDSRSGDEPDSQFDVFARAMDSAIEARNIMWTSMLPCLSDDITQHLRSQAHGRFLDMIPSSKAPNLAELATSEDRIQLAKNLLGVIEAIISGQPPSKSAQLTSMLVDKLTDLWEIISSHETSAARDAVRKHWLPFLLRFITLHSIYSSSSADVSTPTAASASGASSSVVNKTVSNVGAPAATTTATNIITNTNNEARARIVFVLCGILFALEAQQTLPPDGKLAQQVFDIALLLVDALPDDLRLHCARGVLANPSAATSSRGGTSDSRIYYVFSAPRPTAADNLMLAHRDKSAIPLSAAARGLGAMYGIGPTLQERYSHFTFRRWEALSEPTPNVGENDTSLSLGLFEAIKIQ
Length1564
PositionKinase
OrganismBeauveria brongniartii RCEF 3172
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Beauveria> Beauveria brongniartii.
Aromaticity0.05
Grand average of hydropathy-0.216
Instability index46.46
Isoelectric point8.78
Molecular weight171890.89
Publications
PubMed=27071652

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07428
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     329.14|     109|     348|    1067|    1185|       1
---------------------------------------------------------------------------
 1067- 1185 (159.91/92.51)	ILRKLPKKSPLTADESyrfvVYQQSAKIehskALLLLirNAVQEYSILRCRSSTTVPPLDDRSSQDDVLEA..LRVLVVTEPTAAAE.ALSIKD.LAPEASALIRAIAAKL.LSPGDENTSSSF
 1418- 1531 (169.23/79.39)	ILFALEAQQTLPPDGK....LAQQVFDI....ALLLV..DALPDDLRLHCARGVLANPSAATSSRGGTSDSriYYVFSAPRPTAADNlMLAHRDkSAIPLSAAARGLGAMYgIGPTLQERYSHF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     346.27|     100|     348|     142|     243|       3
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   27-  121 (123.81/74.51)	..........QRSISSSH..IQPHSPVRKDafadhNQPTDP..S.DVATASSQATTASRHGATPRRAAGSKLrieLSNDDNMTP..GPATDSPLATPSIASHSAAPDSSTDV
  142-  243 (173.64/115.02)	MPMPQRRGPLQRFVASSKTPAPPTAPLKRD.....SKPKQY..SIEVPLAAPRFLSTNKQDAVHRDPFNKGL...FSGNADFFPwtGRHHEDEWSTEAIQKGTWDRGSQNET
  269-  317 (48.82/23.40)	GVLNQRRNRGQITAPSTFKP.PPRVTL.TD.....TKREVWlkDLANPTISLRRLS........................................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     302.21|      97|     551|     746|     844|       6
---------------------------------------------------------------------------
  746-  844 (156.33/97.52)	IKHDDPtlPSKPIPLRKLL.SRINSSSFALKSALGTHIRDAFQRLLPPRLDAEISL.NVFTSTRTILETTRDFSMLGEVIRSCSK.ISNIEVLAACVDTINV
 1300- 1399 (145.88/85.67)	IISGQP..PSKSAQLTSMLvDKLTDLWEIISSHETSAARDAVRKHWLPFLLRFITLhSIYSSSSADVSTPTAASASGASSSVVNKtVSNVGAPAATTTATNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     173.97|      58|     402|     559|     655|       9
---------------------------------------------------------------------------
  592-  655 (86.40/108.95)	KTLIEWVTSF....HRPGLEKIYTatnLLRSWGSFRINT......TGAILDALDSIEPDDiVRKQAVYrlVTEL
  996- 1063 (87.57/39.83)	KLMSDWVSHIrslkERPALLELLP...LLVSLGCLTMATvlhtanAAPVAANVNTIESGP.PRGSAIY..LEEL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07428 with Med12 domain of Kingdom Fungi
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