<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07427

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGIVNMENGGLNGTHPNHDRNLKANGINGGKMEGQPSPNKGKAAADTPSLDNLANGAPDSQGKQQTQMSTGLTLQQKPRMNDLPEEIVHITQGYIPLSMIVSRLAQRTHEDLQKTIMDMAAIKWAPPAVNGNTPHGTDAPDDMSEGNKRKKMLMLKFAQDAHSKWVKALVITDWSRNAEAVSKLIDIKAHIDSKRMLFDFCQDLLIDLKRSLISARLPNPDLKTALQVLTTGEASWIPEPGYIPPPPLTPEEQLKWIDDLNTMLSLRLNLDDYDKIPHQFKNYTIQSGRVTFKVKGEFEVDLTIADEDFTKQFWFIDFRFAFSPSSGKLSDALVSYLELRVNEILGQDGLEGCYRFLHEFVLTHKINELKRQAIELSRSTWTGTLMVEPLNRALALQYWTTRYGPNGPKSWVMVAVNSAKKTNGQTDPKHSSRLVARWYRDNKEVKDVFLPFDVDNLCAEDLLKTAVARHVEHVLSSIHTKLLSYPRFVKRESSMTLKISRTEPMESSLSMQLGSRDNVTLIIQPVTGFAAIRPHTKYSLNGENRLNYGGKDPAEDGVTCLENIRWGYVIEEFNRRGRSVGWKACKSPIGSEDTKQIIRTREAFQTIFLQRQSLGQEWYVMVSLSLSGDEWWLLEVDRNTPARPIKFQTKLELTRGQPDLDDSFWSNLTIFVTGIITQATDLEDLHHKEVKYLTKESTNYSLPQQVRLPSLILKLSQILRSSEFSTHDASKDAPNQSDNHNSSWAQDQIEVKFKGLQPQPSVTQGPDGNALSGVEVLENVRLNTVVDATVRVKDKAKFALLKGRIDRDVSFNPKKGEFIFRIRQLVGQPILETLTTHVKSIDRLVGFLEAMGKARGDVKCERISLRQVIFTYSDITMPNESDTTQKPKRWRVSLDLAKSDIRMYLERGNPHVRVLDLLTTLVNTQDGLKALLIYMPLLLPILRTLDNIESKWEPLATTNQGRLEIFARSIDWIALRYTLPSPNGQPRILALEIRSKLRRSEVWWNFSRMTPGGPPPPDEEFNKVLKGIWESHGDGWRGLTTGAAALPGPSTMELLTKLDDAVRAYAVTNDISEAPSTQGAQTQPSQTFSANQSFGTQPTSVSQGSNRSSGGSKQAPLVLD
Length1121
PositionTail
OrganismColletotrichum incanum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum spaethianum species complex.
Aromaticity0.07
Grand average of hydropathy-0.463
Instability index40.82
Isoelectric point8.58
Molecular weight126076.08
Publications
PubMed=27189990

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP07427
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     286.47|     120|     142|     610|     745|       1
---------------------------------------------------------------------------
  610-  676 (58.37/67.26)	....................................................................................LQRQ.SL..GQEwyvmvSLSLSGDEwwLLE.VDRNT....PARpIKFQTKLELTRGQPDLDDSFWSNLTIFVTGI
  677-  823 (158.87/148.92)	ITQATdLEDL..HHKEVKYLTkesTNYSLPQQVRLPSLILKLSqiLRSSEFSTHDASkdAPNQSD..NHNSSWaqdqievkfkgLQPQpSVtqGPD.....GNALSGVE..VLEnVRLNTvvdaTVR.VKDKAKFALLKGRIDRDVSFNPKKGEFIFRI
  827-  891 (69.23/44.77)	VGQPI.LETLttHVKSIDRLV...GFLEAMGKARGDVKCERIS..LRQVIFTYSDIT..MPNESDttQKPKRW......................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.18|      32|     576|     335|     410|       2
---------------------------------------------------------------------------
  335-  410 (33.27/86.02)	VSYLELRVNEILGQDGLE.gcyrflhefvlthkinelkrqaielsrstwtgtlmveplnraLALQYwtTRYGPNG.PK
  913-  988 (31.92/13.62)	VRVLDLLTTLVNTQDGLKalliymplllpilrtldnieskweplattnqgrleifarsidwIALRY..TLPSPNGqPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.02|      22|     142|     222|     249|       4
---------------------------------------------------------------------------
  226-  248 (41.28/32.96)	ALQV...LTTGEASW...IPEPGYiPPPP
  991- 1018 (36.74/11.99)	ALEIrskLRRSEVWWnfsRMTPGG.PPPP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07427 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVTNDISEAPSTQGAQTQPSQTFSANQSFGTQPTSVSQGSNRSSGGSKQAPLVLD
2) MPGIVNMENGGLNGTHPNHDRNLKANGINGGKMEGQPSPNKGKAAADTPSLDNLANGAPDSQGKQQTQMSTGLTLQQKPRMNDLPEEI
1067
1
1121
88










Molecular Recognition Features






MoRF SequenceStartStop




NANANA