<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07426

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMESSGHNGTRTDHDRDSSVNGVNGANGTPQHAVFSKEKASAATGTDDSAQAINGNDDSRPQDLSQNGQLGQSINRMNDLPDEIAHITQGFVPLSLLLTRLAQTSHNALQDKIAEMAKMPVPAAAANGSSSYASSGPDDSSADNLRKKATLTNFAQEWHGKWLKALVITEWSRKSHLVSKLIDLKFHIDQQRILYDAALDEMVNVKRDLTFARMPSPDLKTALQVLSTGDAPWMPDLGYVEPPLLTPEVQLKWMNELNTLLSLRLNLEDFDKVPYYFRNYEISSGRVTFKVEGEFEVDLTIADENFDKQFWFIDFRYAFTPAVSSIPQTLRGHLDNCVNDVLGKEGLLGCYQFLHELVLTTKINELKRQAMQLSRTSWTGTLNVESLNRALSIQYWTGRSATMGSKSWVLVAVNSNRSKNSQELASSTSQLVAKWYRDNKEVKDVEIEFDVNELSTEALLTNVIARHIEHILTSIHDRLLSATRFKNHEASMALRISRTDPAFSCLTTQVGHSGEASMLLEPMTGVFALKPPSRFTIQPEHQLNLGKNPAEDGLNCLESLRCAIMEDELHRRATLMGWVVRKAPMAAEEVKAAIRVREWTRSIWLQKDGWGPDWFVIVVLSLSGDEWWLLESSRSETSKTLRFQARIPLKHGYPDLSDVFWDNLAFFTTGVIAQSVDLRELHRQKIKSRSSDRINLSLSQAVRLPSIDVALSALFPSMVFDKDKPEEMTLPNSGEQLDDLVLLSLIQRASGASMTRKKAWADNIVSITFKGIKYLSKAGNLDGGTQDNELICTSEAILRVRRPSKFASLDGLADRDVSYNSKRGEFALRIQRAVGKPILDTLKSRIQAIDRFVNFLEALDWAKGTITTESVTLRQITFYYSQLGTKVTDEVQEQAMEESPKRWRVVLDLSKDDIDIRIETGNPHLRVLDLMRQLVNSEGGIGVLMAWLPASLPALQAIDKMETKWEPVQAAGQGRFEFSMKTIAWMSVEYTIASDIKTINKPIRLEVRMRPRRSQAWWHVWRSDAEANVEDAVSTALRPIWNQRGNDWLGLATSAAGRPQHGVVEMLLAVDDAIRGTATDGAGWGREDEVVVLD
Length1093
PositionTail
OrganismMetarhizium rileyi RCEF 4871
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Metarhizium.
Aromaticity0.07
Grand average of hydropathy-0.334
Instability index40.06
Isoelectric point5.91
Molecular weight122562.61
Publications
PubMed=27071652

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07426
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.45|      11|      18|    1031|    1044|       1
---------------------------------------------------------------------------
 1031- 1044 (15.53/16.64)	AVSTALRPiwnQRG
 1051- 1061 (21.92/11.44)	ATSAAGRP...QHG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.53|      47|     108|     723|     778|       2
---------------------------------------------------------------------------
  723-  778 (67.97/58.63)	KPEEMTLPNSGEQLDDLV.LLSLIQRASGaSMTRKkawadnivSITFKGIK.YLSKAG
  835-  883 (71.56/41.70)	KPILDTLKSRIQAIDRFVnFLEALDWAKG.TITTE........SVTLRQITfYYSQLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.01|      17|      97|      25|      41|       4
---------------------------------------------------------------------------
   25-   41 (29.77/16.65)	ANGTPQHAVFSKEKASA
  125-  141 (29.24/16.24)	ANGSSSYASSGPDDSSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.06|      12|      18|      50|      66|       6
---------------------------------------------------------------------------
   50-   66 (16.23/25.53)	QAINgnddsRPQDLSQN
   71-   82 (22.83/15.51)	QSIN.....RMNDLPDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.96|      13|      19|     895|     908|       9
---------------------------------------------------------------------------
  895-  908 (20.48/16.20)	MEESPKRWRvVLDL
  917-  929 (23.48/13.60)	IETGNPHLR.VLDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.62|      44|     200|     316|     369|      11
---------------------------------------------------------------------------
  316-  369 (64.03/64.59)	YAFTPavssiPQTLRGHLDNCVNdvLGK...EGLLGCYQFLHELVLTtkiNELKRQA
  526-  572 (74.59/48.36)	FALKP.....PSRFTIQPEHQLN..LGKnpaEDGLNCLESLRCAIME...DELHRRA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.30|      19|      29|     783|     801|      12
---------------------------------------------------------------------------
  783-  801 (32.83/25.47)	GTQDNELICTS...EAILRVRR
  810-  831 (27.47/20.00)	GLADRDVSYNSkrgEFALRIQR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07426 with Med14 domain of Kingdom Fungi
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