<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07423

Description Transcription mediator subunit med12
SequenceMTSRTPMGVQPRPPQQRTLSSSGLSVQRPTNQRTLSAQYLPQSPVRKENLIDLTGDANDAAVAQNRYGTLPRRGGSRLKLELSNDAMLAQHPVTDSPKSLTPSRLMPQNESSNLTDMSSPASAKGQPIDADNPPMPMPKRRPRFVVPAAVKDSPAPTLAIKKDGRPKPWHFETPAAAPRYAPFGKPRSDAMNKPGFGGSGSGARDTSELGHADFFPWNGNHPEDQYSETVIKTGYYDKPPASSANETSSAKTALFPALKHKSGLNLLSNIFVGVLNQRKLNGQISSPSTFKPPPRVTLTDTKREMWLRDLANPSISLRRLSRTIPHGIRGKVLLDHCLNKNVPTERAVWLVKCVGANEIRAFKRKGNGPGPFVLGGEAKWLRDWTVFVEQFVEGVSTAFADNDWKAKVQYAIRLATHLYAEQLLDRDHYMDWLVSGLENSTQSKLPMWVLITQIYWKDLLRLRKYGRRLVNALLSHLHTIHNDPDRDILVQLSTRLTSLLMPLLSAHPDNFVSPATWFKYRDALLASIPIDHEFAQTAFKSINIRNEQLVASASNSQPANRQILVKNLDTTFTSLYSPDLAAQCWAVSEDKGMIVRTLLEWCTSPHRPGAAKVYITASLLRAWVVAGVDVTTAVLEYLSNNPPTETNSKRVFHRLMSEIVRTGDFQLQGYIFWLIARGGLRKPADTEADGSCATRLLVDLPLHALNSSSQATRASLLRRASYDVNDEAEDINTALKCIQHALGLPLPPGDPMLQRKPVPVGKLCRLIANSNRALQTEVGARLLQIFTTEIITTKNGPQVSPAMFNFARAVLEAAADFSVLAEIIKLVTRASNPEILASCADTLNVHLPIFAALGGAKELFDFLMERLKAVSEEQGPAARPLLASLANLAARLPGFTNTAGYLRQQLHQCDRNNPIDACSPVSDNMTAQLQDAEGELHEEIEKLLTSGTSVDRPTMDRLFQTVVGRLESCWSNSPDRQRAYSALLGRLRVFDTQHFDVRMTDWVHHISALKARPALVDIYPLLISMGCLTLPIILTTTSIDAGRIALNSSGPINSTTTYMQEVLYLTTMPLAVKTALTPEETYRFYIQQQVAPRQNHKDMVVLVRNALVEYSRLQGAADLALLPLANPGFKNSVLELLKFLVLRDPPSVVQALGTKTPEPALTSLFAQITSKLLLPDTSDESPLTFETVLELANEFTLPFCQLKLSIGLSADSTTSPGGGEQALTQFDMFSRAMDRAVSANNVMWTSMLPYLSEEITEHLKKQAHLRFLGLFPSQKNTPASDPLSHESVQLAGSLLSVVEAILRGRPAARTSQLTSGMVEKLAELWEILAAGDDGKRELRASILQYWLPALLRFITLHTTANEPVSAPAQAQAANNMKPPTNAAVFEIRARILVVLSGLTLELDNLALQNPQTGRLLSQQIFDLALLLIDTLPEDARLQCVRVLLTGGTMQNPASSDARLRYLFSHMPPQTEQFVLAHRQQPATQQNGPPRPKIPISMQGTDKLTPFIYRKWEMLSEPTPNVGENDTALSLTLFEAIKIQ
Length1539
PositionKinase
OrganismColletotrichum incanum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum spaethianum species complex.
Aromaticity0.07
Grand average of hydropathy-0.216
Instability index42.48
Isoelectric point8.94
Molecular weight169878.78
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07423
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     853.01|     311|     365|     619|     983|       1
---------------------------------------------------------------------------
  526-  848 (303.19/244.36)	.........................................................................ASIPI.DHEFAQ..TAFKSINIRNEQLVASasnSQPANRQilvknldtTFTSLYSPDLA..AQCW...AVSEDK..gmivrtllewctsphrpgaakvyitASL..LRAWVVAGVDV.TTAVLEYLS..NNPPTETNskrVFHRLMS......EIVRTGDFQLQGYIfWLIARGglrkPADTEADGSCATRLLVDLPLhalnsssqATRASLLRRASYDVNdeaedINTALKC....................IQHALGLPL.PPGDPMLQRKPVPVgkLCRLIANSN....RALQTEVG.ARLLQIF...TTEIITTKNGPQvSPAMFnfaRAVLEAAADFSvlaeiiklvtrasnpeiLASCADTLNVHLP
  849- 1209 (455.79/280.20)	IFAALGGAKEL..FDFLMERL.KAVSeeqgpAARPLLAS.LANLAARLPGFTNTAGYLR.QQLHQCDRNNPidACSPVSDNMTAQLQDAEGELHEEIEKLLTS...GTSVDRP........TMDRLFQTVVGRLESCW...SNSPDRQR......................aysALLgrLRVFDTQHFDVrMTDWVHHISalKARPALVD...IYPLLISmgcltlPIILTTTSIDAGRI.ALNSSG....PINSTTTYMQEVLYLTTMPL........AVKTALTPEETYRFY.....IQQQVAPrqnhkdmvvlvrnalveysrLQGAADLALlPLANPGFKNSVLEL..LKFLVLRDPpsvvQALGTKTPePALTSLFaqiTSKLLLPDTSDE.SPLTF...ETVLELANEFT.................LPFCQLKLSIGLS
 1213- 1336 (94.04/35.92)	TTSPGGGEQALtqFDMFSRAMdRAVS.....ANNVMWTSmLPYLSEEITEHLKKQAHLRfLGLFPSQKNTP..ASDPLS.HESVQLA...GSLLSVVEAIL.R...GRPAART........S..QLTSGMVEKLAELWeilAAGDDGKR.........................................................................................................................................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.22|      13|      15|       7|      20|       2
---------------------------------------------------------------------------
    7-   20 (22.44/16.06)	MGVQpRPPQQRTLS
   24-   36 (24.77/12.30)	LSVQ.RPTNQRTLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.11|      20|      25|     120|     144|       4
---------------------------------------------------------------------------
  120-  143 (34.90/30.26)	PASAKGQPidadNPPMPMPKR.RPR
  147-  167 (29.21/10.91)	PAAVKDSP....APTLAIKKDgRPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.03|      20|      20|    1395|    1414|       7
---------------------------------------------------------------------------
 1395- 1414 (32.96/18.67)	LSGLTLELDNLALQN.PQTGR
 1416- 1436 (28.07/14.80)	LSQQIFDLALLLIDTlPEDAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.71|      14|      16|     322|     337|       8
---------------------------------------------------------------------------
  322-  337 (21.12/17.08)	RTIPHGIrgKVLLDHC
  340-  353 (25.60/13.61)	KNVPTER..AVWLVKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.43|      21|      25|      58|      78|       9
---------------------------------------------------------------------------
   58-   78 (37.97/23.46)	NDAAVAQNRYGTLPRR.GGSRL
   84-  105 (34.46/20.51)	NDAMLAQHPVTDSPKSlTPSRL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07423 with Med12 domain of Kingdom Fungi
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