<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07420

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTSEYDTNTLLNNNISSIVYRVYEPSQEQAQTFPSAAADVETELRNRGHIVYYDATRRFLWYFYVPSKDAASGDESDGFLGNNISVAGATLLMADEGSFEPASLFKGRAPGQQSANTPTSSSSSNSALDLSLRNPQTGTAGPPSSSDPELKGTGSVALPDAYEQFITALLSTISAAFCSRISAIPLNHRTVLLPSKVTRDGLAERALDTESAVVGTFRIYLTTTGALVMSLSLSCCEGLLSVNEPSTPSQLVLGSQILAAPFGVLANYQGFVGGGLSYPELGLGQTPDTQLWRTADARSSQWRDTCIKLLQSRGLSPTLLQSCPWIALQMLRRKSGEHKIDGKMAPIPSTLATISWPAVLCFRKKSVMLARNNGLGDSVLLAQDETSDFLNDARTWFQLGADRDEKVSKRKKEREIAASKEAAAAAPPQQANGHSPLGLRRASNAAAAGTMYPTPPDGVQNPLGITPSMDGTTSSPGASGTTMAVVDIDTTMADTGTHDTSTMITNQHNESYGDGWHSNDGKRDRADSFLAGDNDNLFGDIGPDMFGDTDITDADFSFFDEEGGDDLDLSGLPDMSMPDAPSAPTTVSIPVSEPAKVVVPAVEEAKPVPSPPIFAKPELKHARSTLLDEGKQRLNAEKAAGVKRESSPFDPDTVYKRVRASLADIRSTPQRTPARKGSIFDSVDFDPVLPLVNKKYEQGGRFDCPPIFQGQSQDTSKQPASQGPPTTDYLRRHGKQRKALRQPEYTNALIRTITGNLENSSLTVSPGKGDELASDADDISLVSDQDDSSVSEDEPTSPFKSSIRRLNLDDDVASHVTSLRDIESVDDSDPALALDLPKIAKAEASEILIPKYFEDAESLPIYLSLPDEDTITIAQIVTEQAVTGSLRIRDALSNTLNTAIVSDTRRQLSSLGRTALQALREVIPPCLGEFNTCNFKGLVEVPDVPLIGPPSRLHPRPVNPRDNVEPPKPNNLFQIPAPHMELRRAESRLSVLPASVQFWESLGLGPAQGTKDVNVVCVFPHWDGMSDVAAAFLDRMRNVYELLKLGSFERLPSSSKVADGLVPFEADKIATSPGTVSPHIVAGLGDRMEALNQGLISANATEKNFVIYFVYPPDHPGSIVEACAAFQQLFEMHRRSLTDRRQTPTNELVLQLVPLDFLTSSTGMVEPTPSDAIKLAIETYDRCTLFGGPMPSPAIMLEQSLPRGIDFKLSNTSSSSLMHENTCIHIAYAQSIDERWITAAWTDNRGCQQMTASYNLGRKGKPLSTSLNDVCHEIWETTHDLISKWKVHWRVVISKCGFMDAQEIGFWQGLAQTESVATVSLTLISADTNPSMQLIPPAIKVPGTASSAFYTTPVSTPQASIVSPEQSGTLVTPMKENNPANAATPGGTPGDGNAEPAEGDAILLDVTDQTWGAVLAHRLSNSSSLGELHPALISGYLVKRGGTKLEDPPVVMEVNIVHADNNPRMYEPLMREMLTYFRGLGTLARARGVIDRGTDVRPWHIAAAEKGVRALYLLM
Length1516
PositionKinase
OrganismColletotrichum tofieldiae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum spaethianum species complex.
Aromaticity0.06
Grand average of hydropathy-0.305
Instability index46.31
Isoelectric point5.01
Molecular weight163762.16
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07420
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     314.72|      76|      91|    1001|    1079|       1
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  911-  979 (89.07/50.93)	.SL..GRTALQAL.REVIPPCLgeFNtcNFKGLVEVPDVPL.............IGPPSRLhPRPVNPRDNVEPPKPNNLFQIP...AP
 1001- 1079 (125.43/82.57)	ESL..GLGPAQGT.KDVNVVCV..FP..HWDGMSDVAAAFLdrmRNVYELLK..LGSFERL.PSSSKVADGLVPFEADKIATSPGTVSP
 1090- 1168 (100.22/58.33)	EALnqGLISANATeKNFVIYFV..YPpdHPGSIVEACAAF....QQLFEMHRrsLTDRRQT.PTNELVLQ.LVPL..DFLTSSTGMVEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     185.61|      75|      91|     573|     663|       2
---------------------------------------------------------------------------
  143-  192 (46.28/14.05)	PPSSSDPELKGTGSVALpDAYEQFITALlstiSAAFCSRISAiPLNHRTV.................................................................................................................................................................................................................................................................................................................................................................................................................................
  575-  605 (30.46/ 9.88)	..................................................llpskvtrdglaeraldtesavvgtfriyltttgalvmslslsccegllsvnepstpsqlvlgsqilaapfgvlanyqgfvggglsypelglgqtpdtqlwrtadarssqwrdtcikllqsrglsptllqscpwialqmlrrksgehkidgkmapipstlatiswpavlcfrkksvmlarnnglgdsvllaqdetsdflndartwfqlgadrdekvskrkkereiaaskeaaaaappqqanghsplglrrasnaaaagtmyptppdgvqnplgitpsmdgttsspgasgttmavvdidttmadtgthdtstmitnqhnesygdgwhsndgkrdradsflagdndnlfgdigpdmfgdtditdadfsffdeeggddldlsglpDM.SMPD.APSAPTTV..SIPVSEPAKVVVPAVEE
  612-  699 (108.87/75.29)	PPIFAKPELKHARSTLL.DEGKQRLNAE....KAAGVKRESS.PFDPDTV.....................................................................................................................................................................................................................................................................................................................................................................................ykrvraslaDIrSTPQrTPARKGSIfdSVDFDPVLPLVNKKYEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     203.83|      66|     291|     420|     490|       3
---------------------------------------------------------------------------
  420-  490 (101.43/65.38)	SKEAAAAAPPQ....QANGHSPLGLRRASNAAAagtMYPTPPDGVQN.PLGITPSmDGTTSSPGASGTTMaVVDID
  717-  787 (102.40/52.41)	SKQPASQGPPTtdylRRHGKQRKALRQPEYTNA...LIRTITGNLENsSLTVSPG.KGDELASDADDISL.VSDQD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.44|      14|     499|     700|     713|       6
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  700-  713 (29.68/17.30)	GGRFDCPPIFQGQS
 1188- 1201 (27.76/15.64)	GGPMPSPAIMLEQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.55|      11|     688|     210|     220|       9
---------------------------------------------------------------------------
  210-  220 (19.91/12.71)	TESAVVGTFRI
  879-  889 (19.64/12.44)	TEQAVTGSLRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.54|      41|     981|     255|     304|      12
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  255-  304 (58.63/49.71)	GSQILAAPFGVlanyqGFVGGGLSypeLGLGQTPDtQLWRTADARSSQWR
 1247- 1287 (76.91/40.37)	GCQQMTASYNL.....GRKGKPLS...TSLNDVCH.EIWETTHDLISKWK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07420 with Med13 domain of Kingdom Fungi
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