<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07417

Description Transcription mediator subunit Med12
SequenceMGVQPRPPQQRTLSSSGLSVQRPTNQRTLSAQYLPQSPVRKENLIDLTGDANDAAVAQNRYGTLPRRGGSRLKLELSNDAMLAQHPVIESPKTLTPSRLMPKNESSTLTDMSSPASAKGQPIDADNPPMPMPKRRPRFVVPAAVKDSPAPTLAIKKDGRPKPWHFETPAAAPRYAPFGKPRSDATSKPGFGGSGSGARDTSELGHADFFPWNGNHPEDQYSETVIKTGYYDKPPASSANETSSAKTALFPALKHKSGLNLLSNIFVGVLNQRKLNGQISSPSTFKPPPRVTLTDTKREMWLRDLANPSISLRRLSRTIPHGIRGKVLLDHCLNKNVPTERAVWLVKCVGANEIRAFKRKGNGPGPFVLGGEAKWLRDWTVFVEQFVEGVSTAFGDNDWKAKVQYAIRLATHLYAEQLLDRDHYMDWLVSGLENSTQSKLPMWILVTQIYWKDLLRLRKYGRRLVNALLSHLHTIHNDPDRDILVQLSTRLSSLLMPLLSAHPDNFVSPATWFKYRDALLASIPIEHEFAQTAFKSINTRNEQLVASASNSQPATRQILVKNLDTTFTSLYSPDLAAQCWSISEDKGMIVRTLLEWCTSPHRPGAAKVYITASLLRAWVAAGVDVTTAVLDYLSNNPPTESNSKRVFHRLMSEIVRTGDFQLQGYIFWLIARGGLRKPADTEADGSCATRLLVDLPLHALNPSSQATRASLLRRASYDVNDEAEDINTALKCIQHALGLPLPPGDPMLQRKPVPVGKLCRLIANSNRALQTEVGARLLQIFTTEIITTKNGPQVSPAMFNFARAVLEAAADFSVLAEIMKLVARASNPELLASCADTLNVHLPIFAALGGAKELFDFLMERLKAVSEEQGPAARALLASLANLAARLPGFTNTAGYLRQQLHQCDRNNPIDACSPVSDNMTAQLQDAEGELHEEIEKLLTSGTSVDRPTMDRLFQTVVGRLESCWSNSPDRQRAYSALLGRLRIFDTQHFDVRMTDWVHHISALKARPALVDIYPLLISMGCLTLPIILTTTSIDAGRIALNSSGAITSTTTYMQEVLYLTTMPLTAKTALTPEETYRFYIQQQVAPRQNHKDMVVLVRNALVEYSRLQGAVDPALLPLANPGFKNSVLELLKFLVLRDPPSVVQALATKTPEPALTSLFAQITSKLLLPDTSDESPLTFETVLELANEFTLPFCQLKLSIGLSADSTTSPGGGEQALTQFDMFSRAMDRAVSANNVMWTSMLPYLSEEITEHLKKQAHLRFLGLFPSQKNPPASDPLSHESVQLAGSLLSVVEAILRGRPAVRTSQLTSGMVEKLAELWEILAAGDDDKRELRASILQYWLPALLRFITLHTTANEPVSAPAQAANNMKPPTNAAVFEIRARILVVLSGLTLEVDNLALQDPKTGRLLSQQIFDLALLLIDTLPEDARLQCVRVLLTGGTMQNPASSDARLRYLFSHMPPQTEQFVLAHRQQPVAQQNGPPRPRIPISMQGTDKLTPFIYRKWEMLSEPTPNIGENDTALSLTLFEAIKIQ
Length1531
PositionKinase
OrganismColletotrichum tofieldiae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum spaethianum species complex.
Aromaticity0.07
Grand average of hydropathy-0.210
Instability index43.48
Isoelectric point8.90
Molecular weight168994.85
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07417
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     345.32|     120|     129|    1157|    1285|       1
---------------------------------------------------------------------------
 1131- 1215 (61.82/50.59)	...........................................LKFLVL....RDPPS................vvqalatktpepaltSLFAQITSK.LLLPDTSDESPLTFETVLELANEFTLpfcqlkLSIGlSADSTTSPGGGEQ
 1216- 1338 (189.02/126.15)	ALTQFDMFSRAMDRAVSANNVMWTSMLPYLSEEITEhLKKQAHLRFLGLFPSQKNPPASDP.....LSHESVQL.............agSLLSVVEAI.LRGRPAVRTSQLTSGMVEKLAELWEI......LAAG.DDDKRELRASILQ
 1343- 1425 (94.48/53.89)	ALLRFITLHTTANEPVSAPAQAANNMKPPTNAAVFE.IRARILVVLSGLTLEVDNLALQDPktgrlLSQQIFDL........................aLLLIDTLPE.........................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     423.40|     120|     129|     633|     760|       2
---------------------------------------------------------------------------
  633-  757 (178.42/121.65)	.....................SNNP.....PTESNSKRVFHRLMSEIVRT.....................GDFQLQGYIFWLIARG.GLRKPADTEADGSCATRL...LVDLPLHALNPSSQATRASLLRRASYDVN..DEAEDInTALKCIQHALGlplPPGDPMLQrkpvPVGKL
  758-  882 (138.26/77.89)	CRL...............ianSNRA.....LQTEVGARLLQIFTTEIITTkngpqvspamfnfaravleaaADFSVLAEIMKLVARA......SNPELLASCADTL...NVHLPIFAALGGAKELFDFLMER.................LKAVSEEQG...PAARALLA....SLANL
  884- 1004 (106.73/56.61)	ARLpgftntagylrqqlhqcdRNNPidacsPVSDN........MTAQLQD.....................AEGELHEEIEKLLTSGtSVDRPTMDRLFQTVVGRLescWSNSPDRQRAYSALLGRLRIFDTQHFDVRmtDWVHHI.SALK...........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.27|      22|      73|     480|     501|       3
---------------------------------------------------------------------------
  480-  501 (38.01/21.35)	RDILVQ.LSTRLSSLLMPLLSAH
  555-  577 (34.27/18.52)	RQILVKnLDTTFTSLYSPDLAAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.61|      51|     130|      57|     115|       4
---------------------------------------------------------------------------
   65-  115 (88.75/66.30)	PRRGGS....RLKLELSNDAML...AQHPVIESPKTLTPSRLMPKNESSTLTDMSS......PA
  188-  251 (75.86/41.04)	PGFGGSgsgaRDTSELGHADFFpwnGNHPEDQYSETVIKTGYYDKPPASSANETSSaktalfPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.22|      13|      15|       1|      14|       6
---------------------------------------------------------------------------
    1-   14 (22.44/14.89)	MGVQpRPPQQRTLS
   18-   30 (24.77/11.33)	LSVQ.RPTNQRTLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.18|      16|      18|     314|     331|       7
---------------------------------------------------------------------------
  314-  331 (24.18/18.40)	LSRTIPHGIrgKVLLDHC
  332-  347 (29.01/15.32)	LNKNVPTER..AVWLVKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.98|      11|      20|     585|     595|      10
---------------------------------------------------------------------------
  585-  595 (20.66/12.23)	KGMIVRTLL.EW
  606-  617 (15.32/ 7.28)	KVYITASLLrAW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.86|      14|     923|     148|     164|      12
---------------------------------------------------------------------------
  148-  161 (24.67/16.70)	PAPTLAIKKDGRPK
  174-  187 (25.19/ 7.10)	YAPFGKPRSDATSK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07417 with Med12 domain of Kingdom Fungi
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