<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07399

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDGRVVRGVQRAALEQWSEFIARSLAHRIDPDKFESYIPFLQVKHPLPPVAVADLFLRPQPHNHESLDPRVPRYLQVLSDLNYIDTHSILKALYRYSTSRAHSQDAAQPVNGETQRPNIPRWGSSYAAEEVMFYRLTKSVAQGTAIQNTGTGLEIANIMAKWIALFTDAATAFTVDVMGQLHNSQVREEMESARAAFVALLLGVCENQVVLKALSKPEAQDTRKALSESLANFVPTIMQSAGPIATRLDMFRTSTLAGFEPVDEQKNKSNAEIEDLFDSTVALENFVISELPIVNSRAGLYIYLNAALVGRPLIDDLAIFNYLNNRYQGDVQSTTVDLILASFDVLANAASRNEGNQAAHLLRSFLMNKLPTLIESLSKHMYGPVNAEYCITEALGRVDTTTFPTLSSMFDETRSNNPFTDSVREEFCWACCLHGLVRESSIETLLGETPYQSLPAGGRYVKENLVAECLADPERMQALIGELDNKDGNAGAVCQALTEVMGQLCRNKETMSLKLLCSQLAQKPLSLDVMLMFEKPATILHPLCDLLDNWKYDEDQGEYQPVYEEFGSILLLVMAFAYRYGLSASDMGVASSDSFVARLLGQGHQSRPFDELSDQEKGHLNGWIHGLFDSEAGGLGDELMSSCPPQDFYLLVSTLFQNIVLAFSTGHLAEESLRGGIEYLVDTFLLPSLVVAITYLANSLWVERSDCQKAIVRVLHSVLAPTSISNEAQAMLTSVMNIVAKPLEHSLRAYQRSDPKSQEVEPLLKAIKDSIPLSRRTGAADHTELDAWSLGGFSNSIRQTLQQLVQWSIHPTMDRMPPAYTHRQMLVALKLLGAKRLLQLLYEDIRQQTDTGSGSIIYDVATAIVCAPDVVNTPSNPVNFLDNSGNMPAPVQRKLTLREVLKSDAEDCKRLQKTDMNLAEIVVRLYRKVESQMAVSQAQAIQADTMLQNDLGLGLDTGAGSLDDAMAAAAANVAQGDGMSVDNVSLDLGLGGVGGDMGLGGSSNNGGGSLDLGTDDIFSGLGAGDDFQWDNMDLS
Length1035
PositionTail
OrganismColletotrichum tofieldiae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum spaethianum species complex.
Aromaticity0.07
Grand average of hydropathy-0.116
Instability index41.41
Isoelectric point4.83
Molecular weight113458.40
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07399
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.25|      16|      21|     985|    1004|       1
---------------------------------------------------------------------------
  985- 1000 (30.84/21.12)	SLDLGLGGVGGDMGLG
 1009- 1024 (27.41/ 9.28)	SLDLGTDDIFSGLGAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.26|      20|      26|     494|     517|       2
---------------------------------------------------------------------------
  496-  517 (30.84/29.66)	ALT......EVMgqLCRNKETMSLKLLC
  519-  544 (31.42/14.53)	QLAqkplslDVM..LMFEKPATILHPLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.82|      25|      26|     230|     255|       4
---------------------------------------------------------------------------
  230-  255 (41.00/33.28)	LANFVPTIMQSAGPIATRLDMFrTST
  256-  280 (42.82/29.44)	LAGFEPVDEQKNKSNAEIEDLF.DST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.24|      19|      26|     937|     956|       6
---------------------------------------------------------------------------
  937-  956 (28.29/18.19)	QAQAIQADTMLQNDlGLGLD
  964-  982 (31.96/16.58)	DAMAAAAANVAQGD.GMSVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.71|      12|      26|     686|     698|       7
---------------------------------------------------------------------------
  686-  698 (16.33/14.28)	LPSlVVAITYLAN
  715-  726 (19.38/11.26)	LHS.VLAPTSISN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.69|      19|      26|     439|     464|       8
---------------------------------------------------------------------------
  439-  457 (31.97/28.12)	ESSIETLLGETPYQSLPAG
  473-  491 (32.72/12.98)	PERMQALIGELDNKDGNAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.20|      20|      27|     610|     629|       9
---------------------------------------------------------------------------
  610-  629 (37.38/25.10)	DEL.SDQEKGHLNGWIHGLFD
  637-  657 (31.82/20.23)	DELmSSCPPQDFYLLVSTLFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.70|      15|      45|      60|      74|      10
---------------------------------------------------------------------------
   60-   74 (31.16/22.41)	QPHNHESLDPRVPRY
  108-  122 (31.54/22.79)	QPVNGETQRPNIPRW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.84|      23|      37|     375|     398|      11
---------------------------------------------------------------------------
  375-  398 (37.49/29.83)	ESLSKhMY..........GPVNAEYCITEAL.GRV
  404-  437 (33.35/20.64)	PTLSS.MFdetrsnnpftDSVREEFCWACCLhGLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.68|      16|      19|     741|     758|      12
---------------------------------------------------------------------------
  743-  758 (28.28/26.52)	LEHSLRAYQRSDPKSQ
  760-  775 (26.41/14.68)	VEPLLKAIKDSIPLSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      24.27|       8|      19|     339|     348|      13
---------------------------------------------------------------------------
  339-  348 ( 9.19/ 8.60)	ILASFdvLAN
  361-  368 (15.08/ 6.55)	LLRSF..LMN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07399 with Med5 domain of Kingdom Fungi
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