<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07398
Description |
Mediator of RNA polymerase II transcription subunit 5 |
Sequence | MDQGVDAGRVLRDAVEYWTKFVRACISKAPDDEFYEQMARNIYKQNPLPPAILADLFFHPQPDDQVSLVPRMPLYIRILHRLGFIDSLSILRSMYKVSALHDVLKKSGSSQEQNSNGQQDTSVGDKESRRWSTSSWFEEFFFFQIIKAMTDGTPLGDTKDMLELCQIVSQWMDLFTSTSNFFAADVLGQLQESRSRDPKFCMEESRDAFVPLLVRLVETPLLVKTISMSIAKGARKQLSDSMWSFLQTLQPSGLVDRLQIFYTDTLTKLDPDGKKKQAAASAAMEEILETTVGVDNFVIPDLPVPNTRAALYVFLNACLVGRPLIDDNVLISYIHNRYQDQTQAGVIDLILASFDILANAIFRNEGSKDSHVLKSFLVCKVPLLICQLCSAGFDMSTSEYCITEALNQVDTSVFPTASLMFDPSRSNNPYTESVREDFCTACVVHGLIQREHVDRILGESSMSYVSLEKLSKEKLVQDCLASTANIQSLIRDLDKTDGNVGAVAQALVPPLLNGARKFQVLKTEQVMRRLCHNKETISLKMVCSQLAQKPQALDVLLLFEKLPSIVEPLCQVLDNWQYEEDQGEYQPIYEEFGSILLVVLAFAYRYNLSPFDMGIASPDSSVAKIVNWAHISRDPHELSAQQKEHVNGWIEGLFDNESGGLGDDLMSSCPPPDFYSLVASIFQRIIVAYTVGYLNDDALKGGIEYLVDTFLLPSLVPAMRFLADYLWVEQSEQKAVIKILQLLLLPSSISGEASAMLSSVCNLVAKPLEHSLRTYQRQDPKNQDIEPLLIALKDSLPLSRRTGGADHLELETWANSSGLSGALRHTIQGLVQWAMNPAVNNMPTSYTHRQLIVFVQVTGASRTLQMLLEEIRMHAEAGNPSVVYDVVAAMICAPNVQNEAPWTDGMMMDASGNIAPPVQRSLTLRQALGFARERARKVSKEDALLAEIIVRLHRRVEAHMVMPQPPAILAADAGIPLDLAAGAAGLGDVDALAVAGVGADGVGLDMGLGGPGSAGGLDSTSDGDLFGGLDMNMDSVYWDSMELTGN |
Length | 1046 |
Position | Tail |
Organism | Moelleriella libera RCEF 2490 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes>
Hypocreomycetidae> Hypocreales> Clavicipitaceae> Moelleriella.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.034 |
Instability index | 44.41 |
Isoelectric point | 4.88 |
Molecular weight | 115477.86 |
Publications | PubMed=27071652
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364142
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP07398
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 202.82| 63| 404| 253| 316| 1
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253- 316 (102.94/69.28) GLVDRLQIFYTDTLTKLDPDGKKKQAAASAAMEEILETTVG..............VDNFVIPDLpVPNTR.AALYVFLN
652- 729 (99.88/62.25) GLFDNESGGLGDDLMSSCPPPDFYSLVASIFQRIIVAYTVGylnddalkggieylVDTFLLPSL.VPAMRfLADYLWVE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 84.59| 24| 24| 985| 1008| 6
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985- 1008 (41.09/25.55) GLGDVDALAVAGVGADGVGLDMGL
1010- 1033 (43.51/27.54) GPGSAGGLDSTSDGDLFGGLDMNM
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 127.45| 41| 913| 11| 54| 7
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11- 54 (65.70/58.38) LRDAVEYWTKFVRAcISKapDD....EFYEQMARNI..YKQNPLPPAILA
924- 970 (61.76/41.99) LRQALGFARERARK.VSK..EDallaEIIVRLHRRVeaHMVMPQPPAILA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 89.27| 30| 574| 190| 225| 8
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190- 225 (40.70/38.90) LQESRSRDPKfcmeeSRDaFVPLLVRLVET.PLLVKT
772- 802 (48.57/28.02) LRTYQRQDPK.....NQD.IEPLLIALKDSlPLSRRT
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 65.94| 17| 324| 68| 84| 9
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68- 84 (32.78/22.03) LVPRMPLYIRILHRLGF
377- 393 (33.16/22.37) LVCKVPLLICQLCSAGF
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