<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07398

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDQGVDAGRVLRDAVEYWTKFVRACISKAPDDEFYEQMARNIYKQNPLPPAILADLFFHPQPDDQVSLVPRMPLYIRILHRLGFIDSLSILRSMYKVSALHDVLKKSGSSQEQNSNGQQDTSVGDKESRRWSTSSWFEEFFFFQIIKAMTDGTPLGDTKDMLELCQIVSQWMDLFTSTSNFFAADVLGQLQESRSRDPKFCMEESRDAFVPLLVRLVETPLLVKTISMSIAKGARKQLSDSMWSFLQTLQPSGLVDRLQIFYTDTLTKLDPDGKKKQAAASAAMEEILETTVGVDNFVIPDLPVPNTRAALYVFLNACLVGRPLIDDNVLISYIHNRYQDQTQAGVIDLILASFDILANAIFRNEGSKDSHVLKSFLVCKVPLLICQLCSAGFDMSTSEYCITEALNQVDTSVFPTASLMFDPSRSNNPYTESVREDFCTACVVHGLIQREHVDRILGESSMSYVSLEKLSKEKLVQDCLASTANIQSLIRDLDKTDGNVGAVAQALVPPLLNGARKFQVLKTEQVMRRLCHNKETISLKMVCSQLAQKPQALDVLLLFEKLPSIVEPLCQVLDNWQYEEDQGEYQPIYEEFGSILLVVLAFAYRYNLSPFDMGIASPDSSVAKIVNWAHISRDPHELSAQQKEHVNGWIEGLFDNESGGLGDDLMSSCPPPDFYSLVASIFQRIIVAYTVGYLNDDALKGGIEYLVDTFLLPSLVPAMRFLADYLWVEQSEQKAVIKILQLLLLPSSISGEASAMLSSVCNLVAKPLEHSLRTYQRQDPKNQDIEPLLIALKDSLPLSRRTGGADHLELETWANSSGLSGALRHTIQGLVQWAMNPAVNNMPTSYTHRQLIVFVQVTGASRTLQMLLEEIRMHAEAGNPSVVYDVVAAMICAPNVQNEAPWTDGMMMDASGNIAPPVQRSLTLRQALGFARERARKVSKEDALLAEIIVRLHRRVEAHMVMPQPPAILAADAGIPLDLAAGAAGLGDVDALAVAGVGADGVGLDMGLGGPGSAGGLDSTSDGDLFGGLDMNMDSVYWDSMELTGN
Length1046
PositionTail
OrganismMoelleriella libera RCEF 2490
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Moelleriella.
Aromaticity0.07
Grand average of hydropathy-0.034
Instability index44.41
Isoelectric point4.88
Molecular weight115477.86
Publications
PubMed=27071652

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07398
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     202.82|      63|     404|     253|     316|       1
---------------------------------------------------------------------------
  253-  316 (102.94/69.28)	GLVDRLQIFYTDTLTKLDPDGKKKQAAASAAMEEILETTVG..............VDNFVIPDLpVPNTR.AALYVFLN
  652-  729 (99.88/62.25)	GLFDNESGGLGDDLMSSCPPPDFYSLVASIFQRIIVAYTVGylnddalkggieylVDTFLLPSL.VPAMRfLADYLWVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.59|      24|      24|     985|    1008|       6
---------------------------------------------------------------------------
  985- 1008 (41.09/25.55)	GLGDVDALAVAGVGADGVGLDMGL
 1010- 1033 (43.51/27.54)	GPGSAGGLDSTSDGDLFGGLDMNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.45|      41|     913|      11|      54|       7
---------------------------------------------------------------------------
   11-   54 (65.70/58.38)	LRDAVEYWTKFVRAcISKapDD....EFYEQMARNI..YKQNPLPPAILA
  924-  970 (61.76/41.99)	LRQALGFARERARK.VSK..EDallaEIIVRLHRRVeaHMVMPQPPAILA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.27|      30|     574|     190|     225|       8
---------------------------------------------------------------------------
  190-  225 (40.70/38.90)	LQESRSRDPKfcmeeSRDaFVPLLVRLVET.PLLVKT
  772-  802 (48.57/28.02)	LRTYQRQDPK.....NQD.IEPLLIALKDSlPLSRRT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.94|      17|     324|      68|      84|       9
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   68-   84 (32.78/22.03)	LVPRMPLYIRILHRLGF
  377-  393 (33.16/22.37)	LVCKVPLLICQLCSAGF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07398 with Med5 domain of Kingdom Fungi
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