<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07364
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MLQNVPIQSPARLGLPNPNSPAPPKFSSSQVVQSHHSHQQSNTGSAAVTITSSALLPLLPPLPRAQSLLVQMASLASRLFEVSPNRSHWLSAFRGSLPSFLSSQTQSLAPVPLDSSPSSAKEIIALFTTLQTQLFEAVAELQEILDLQDAKQKINREIRVKDSAILGFANKLREAEQVLDELVDDYSDYRRLKRSKLDGNDDESYTTSIATRIKVNDILSYAHRISYTTFAPPEFGAGQVPLRGALPPAPQEEQMRASQLYAFADLDVGISRTVEDKEAMIEPLIQSPAAQPSESALANMATMQGMIPPNFVIPSGWKPGMPVELPIIPPPGWKPGDPVALPPLDSISGPSRVDEQPARPIIAPGISKAPEPIQVRHVQLDIEDDSDYTSDEASSDDDED |
Length | 400 |
Position | Middle |
Organism | Daucus carota subsp. sativus (Carrot) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta>
Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae>
asterids> campanulids> Apiales> Apiaceae> Apioideae> Scandiceae> Daucinae>
Daucus> Daucus sect. Daucus.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.324 |
Instability index | 69.99 |
Isoelectric point | 4.76 |
Molecular weight | 43440.45 |
Publications | PubMed=27158781
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP07364
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 62.53| 13| 15| 314| 326| 1
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314- 326 (31.07/19.16) PSGWKPGMPVELP
330- 342 (31.46/19.49) PPGWKPGDPVALP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 162.77| 62| 228| 8| 85| 3
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37- 85 (71.45/38.03) SHQQSNTGSAAVTITSSALLPL...LP.PL...P.RAQSLLV.QMASLASRLFEVSPN............................................
87- 175 (67.83/29.17) SHWLSAFRGSLPSFLSSQTQSL...APvPLdssPsSAKEIIA.LFTTLQTQLFEAVAElqeildlqdakqkinreirvKDSAilGFANKLR.........EA
241- 307 (23.48/ 7.87) ....................PLrgaLP.PA...P.QEEQMRAsQLYAFAD..LDVG......isrtvedkeamiepliQSPA..AQPSESAlanmatmqgMI
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