<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07349

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMRFTAAYPRRSNSVLVLFRSYPGDPTLQGYLKCAMKDGLLTPPRFVTTFLLAAQSPDLHHTATLDMLCRVVLDAHYATGLPALGSIIPYSESPSDLLATAQNAMSLLRTAHQLPPSHFHQLTTSASELLTLLISCVSPADISQLPTAQVMMHFAEASDLLQIQNLIPAVRQELETFALSLSLLLGDDAKAAREAQMMHTLQLAYGKGDIMGPTSDTDLVTCGLVLHSFVRFFSLVSRAGDFGAGDSTHAVAVLVALFRWLSWSPTAFFSQLLLAAASCVAQSAILGSSTTSMIIWRAFVVGRLPELLCSFKKTAEAEGLLDGSWHAAIHMGLTNLLRVNILDKCDSIQATPNGDITVDKSIHSVAFALEFLHQMVATDIVDASFAATISPTLSNSFTPRITTEARDAGMDVASYLESKLVADNNNIEEAVSLAGRVCRDACSHSAFAAAVHKRFTSLSQPSDVESLSHICKVMCRCEPAVDIVSIHVSLRELLSSALAFVEGYDCETVGDPQTAVSHLGEVVLFLQEMVARHNVCVFHAPSLLTRTNATTGDRKLDIDFILPVATVYPVHELKGEAAADFQAWNKALFDKNSEGIEDSILRNTRPQTLLRITASLFANAINLCLERKMEKEVLVNGIQYFLGNLLNWTLAGTVKWLLAEIRMKGYNAPVHLEVLQTLLLSPSCPQAVLRLSAPTILRLFPWPHKQERSRTGPFDPSPIRRVALQTLGLPPEGNPKVDHAMHAIRNALAAGRAGKAPAFDLDRCLLATTPARFLSILWRELIAAATMGEMDAARRLATFIMTTPRHSHSPPLLPIFLHAYLPGIVAGADSLPPSEQAITVELIVSVVASALTAALHLERALLTVCNQPNPVLGQSAAAMARNLGSELRSTAHGHNTSSVITQRLTSSPAFVTNFPTFMAEL
Length920
PositionTail
OrganismDaedalea quercina L-15889
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Daedalea.
Aromaticity0.07
Grand average of hydropathy0.216
Instability index46.56
Isoelectric point6.30
Molecular weight99664.91
Publications
PubMed=26659563

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07349
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     222.11|      73|     404|     397|     475|       1
---------------------------------------------------------------------------
  397-  475 (111.11/88.60)	TPRITTEARDAGMDVASYLESkLVADNNNI...EEAVSLAGRVCRDAcshSAFAAAVH.KR..FTSLSQPSDVesLSHICKVMCR
  802-  880 (111.00/69.95)	TPRHSHSPPLLPIFLHAYLPG.IVAGADSLppsEQAITVELIVSVVA...SALTAALHlERalLTVCNQPNPV..LGQSAAAMAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.40|      30|      34|      96|     129|       2
---------------------------------------------------------------------------
   58-   94 (41.51/22.75)	LHHTATLDM.LCRVvldAHYatgLPAlGSIIPYSESPS
   96-  126 (48.89/42.98)	LLATAQNAMsLLRT...AHQ...LPP.SHFHQLTTSAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.93|      26|      34|     207|     233|       3
---------------------------------------------------------------------------
  207-  233 (44.05/38.17)	GDiMGPTSDTDLVTCGLVLHSFVR.....FFS
  239-  269 (40.88/29.56)	GD.FGAGDSTHAVAVLVALFRWLSwsptaFFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.89|      18|      34|     308|     325|       4
---------------------------------------------------------------------------
  308-  325 (33.52/22.76)	C.SFKKTAEAEGLLDGSWH
  344-  362 (28.37/18.16)	CdSIQATPNGDITVDKSIH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.43|      19|     151|     370|     392|      10
---------------------------------------------------------------------------
  370-  392 (25.07/27.73)	FLHQMVATDIVdASFAAtisPTL
  524-  542 (37.35/24.12)	FLQEMVARHNV.CVFHA...PSL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.19|      18|      28|     127|     146|      12
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  127-  146 (26.31/18.87)	ELLTllISCVSPADISQLPT
  158-  175 (29.87/15.70)	DLLQ..IQNLIPAVRQELET
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07349 with Med5 domain of Kingdom Fungi
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