<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07336

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMATAKPPLASQDNTGSTFLAQFPPHISPESSVLASAIALPQYPLIAYAVFSGGPSTRADNLNCIEHARRKVLMQNSGPDILDSLIPAVHISMDSSALYVFAFGSSDRTSEAQGALAALQFDDLARVESSTFQPSSVYPCSAACSTQDIPCSECLNPAHPRVGSSSAHLLPRQSLRLPFYYLLNAVRDRLIDDITEASRHARTHRPAIRYKDGFLLGPSPASSEWSAGWEHPKPSRPLIYSSLEVQLSHHCSRAQLLIHPVLRPTFYLPLCKTSPLPPGAPILLLPYGVPAYYLSTYAGPTSALTSQFQDALMGLGAGDWTGDGLSSAPRDDSRTIQSPTYVIAWLPVQNKQGEDKGMPIIWPLRLCLSYHPSSPSPHARTPLSYIPELPAQLQASPPPPVPAVPATFASGKADATSATSNSRDGTPLQGPGEPPEQGLPPATITRRAAAQRPSTTVDSVRAFRGMTLVSTPSTRSLQMVVSEVSGYVDSVAKERERERERMKREKENANIRARTNSFSGAPVALSPPQPDAEAAQHHRTAEELQPVVELGPPGRSTPAPVTDIPMEQDVDLLFLSSQESSTDSLFSPAEGVSPSSTGDAEPVIDETMVGTGPENIATPPMQLDSSIEVPQDGLATFDSFAGFGDNMNGWASSSSSDFMAVDMGLGTDFGMGTFGSSRSGAGVVGDFDMDDGLGVFTDDDFSFFDAPSVQSRASAPLVTASVDSAIKAGEGLTPTAGPAPLGFPPLRVSDGALSSGPGPPSAVFSNRSPWPQTHIPDSSTPRLLSTAADLPSPAPDLIPPSPTKSASTQSAPATPRVLIADVQDGAVQQKGRYLGIGPSIFDPISFAPGHRSADSKYVFGKFALPSPPDSEDRAENVNFSANGNWMLKYNAATDPRIGMMKKLVGVKRKGLDYARSNTVPAWMRGDEGWESTASSPGDDDEPKSDSESEDEELLVDDEGPASALRSSTPPPSYLPLGPTLLQTRFHHGRLLPLSAPLKPPGSAVDMTAGGPLPASAPTPVSPAAVLGATSEKSRSLEAAVQILVKEVVENNIWADTWRANAAASSMSLKPPYEVWQTDVERVDRLLESVKGSLSPVDLARYFSPALGDGVGDAVSLYTLEPPMLTIGKSDALVQVFPTALRFWEKLGLRPRPGSKDVTAFAFFERSDGRNEEEIGQWLSKISVIYTAKNYGMHVAGTAAMCSKAGLVPVQFDSFKKTLAKFASGLPASAETAYVFYIVTPPTIVTPDSPLLRQLFSAVKRCTKTYPDLRVLYHFVPEALPAGALADSRFNREGLEVFVGAVYDRLLQPVERPVSEQLIMHTEPTRAYFQAPAFSLACALPSRKSLRQHNPITVAFTPESRPSSLDLVNRHMLFHVGYSVTPCKRWLLAAGVDERGDSHEFGAWLLPDEAVDASIVRQVWSFARNCTARVSVEWRLAVAKLGPMGGMELNAWIHHLDSTVVNGPETLPIRVMLLTVENQRSLTFLAPLDRRRPPSSLHPTRVSSTRSPPRGSSGHVFADTATATYAVFPPARASCSPTLSFDFMSGVFPGSLDLPFIQDAEDEGPPAYERLAMRGLARSLLINVPAGTDYTSINSIEIVQLHSACSRTSTSHARYSAEDDAMVVDEGQAQCLGDMNAEDARMLRDVTHNYHALAVLAQARWQPRDAPGLPLHLSALDAMKIALTGGSAGVS
Length1689
PositionKinase
OrganismDaedalea quercina L-15889
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Daedalea.
Aromaticity0.07
Grand average of hydropathy-0.219
Instability index57.21
Isoelectric point5.45
Molecular weight180925.83
Publications
PubMed=26659563

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP07336
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1768.18|     462|     499|     515|    1001|       1
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    8-  432 (423.84/200.06)	........................................................................LASQDNTGSTFlaqFPP..H.ISPESSV............................LASAIALPQYPLI.AYAVFSGgpstRADNLNCIEHARRKVLM...QNSGPDildslipavhismdssalyvFA...FGSSDRTS...EAQG......ALAALQFDDLARVESSTFQPSSVYPCSAACSTQ....DIPCSECLNP.AHPrvgsssahllprqslrLPFYYllnavrdrlidditeasrharthrPAIRYKDGFL.LGPSPA..SSEWSAgwEHPKPSRPLIYSSlevqlshhcsraqllihpvlrptfyLP..LCKTSPLPPGAPILLLPYgvPAYYLSTYAGPTS..ALTSQFQDALM...G..LGAGDWTGDGLSSA.....PrdDSRT.IQSpTYVIA..WLPvQNKQGEDKG...............................M..PIIWPLRLCLSYHPS.........................SPSP.HARTPLSYIP...........ELPAQ.LQAS..........PPPP..VPAVP....ATFASGKADATSAtsnsrdgtPL...QGPGE
  515- 1001 (758.37/416.47)	NSFSGAPVALSPPQPDAEAAQHHRTAEE...........LQPVVE..LGPPGRSTPAPVTDIPMEQDVDLlfLSSQESSTDSL...FSPAEG.VSPSSTGDA.EPVIDEtmvGTGPE.NIAT..PPMQLDSSIEVPQDGLA.TFDSFAG....FGDNMNGWASSSSSDFMAvdMGLGTD....................FGMgtFGSSRSGA...GVVGDFdMDDGLGVFTDDDFSFFDAPSVQSRASAPLVTASVDS....AIKAGEGLTPTAGP................APLGF........................PPLRVSDGALsSGPGPP..SAVFSN..RSPWPQTHIPDSS.........................TPRLLSTAADLPSPAPDLIPPS..PTKSASTQSAPATPRVLIADVQDGAVQQKGRYLGIGPSIFDPISFA.....P..GHRS.ADS.KYVFGKFALP.SPPDSEDRAE.....NVNFSAN..GNWMLkyNAatdprigMmkKLVGVKRKGLDYARSNTVPAWMRGDEG.........WEstASSPgDDDEPKSDSESEDE.ELLVDDEGPASALRSS..........TPPPSYLPLGPTLLQTRFHHGRLLPLSA........PL...KPPGS
 1004- 1494 (585.97/280.71)	DMTAGGPLPASAPTPVSPAAVLGATSEKsrsleaavqilVKEVVEnnIWADTWRANAAASSMSLKPPYEV..WQTDVERVDRL...LESVKGsLSPVDLARYfSPALGD...GVGDAvSLYTlePPML...TIG.KSDALVqVFPTALR....FWEKLGLRPRPGSKDVTA............................FAF....FERSDGrneEEIGQW.LSKISVIYTAKNYGMHVAGTAAMCSKAGLVPVQFDSfkktLAKFASGLPASAET................AYVFY.....................ivtPPTIVT.......PDSPllRQLFSA..VKRCTKTY.PD............................LRVLYHFVPEALPAGALADSR..FNREGLEVFVGAVYDRLLQPVERPVSEQLIMHTEPTRAYFQAPAFSlacalP..SRKSlRQH.NPITVAFTPE.SRPSSLDLVNrhmlfHVGYSVTpcKRWLL..AA.............GVDERG....DSHEFGAWLLPDEAvdasivrqvWS.........FARNCTARVSVEwRLAVAKLGPMGGMELNawihhldstvVNGPETLPIRVMLLTV..ENQRSLTFLA........PLdrrRPPSS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07336 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DSLFSPAEGVSPSSTGDAEPVIDETMVGTGPENIATPPMQLDSSIEV
2) LPLSAPLKPPGSAVDMTAGGPLPASAPTPVSPAAVLGAT
3) PHARTPLSYIPELPAQLQASPPPPVPAVPATFASGKADATSATSNSRDGTPLQGPGEPPEQGLPPATITRRAAAQRPSTTVDSVRAFRGMTLVSTPSTRSLQMVVSEVSGYVDSVAKERERERERMKREKENANIRARTNSFSGAPVALSPPQPDAEAAQHHRTAEELQPVVELGPPGRSTPAPVTDIPMEQDVDLLFL
4) SAIKAGEGLTPTAGPAPLGFPPLRVSDGALSSGPGPPSAVFSNRSPWPQTHIPDSSTPRLLSTAADLPSPAPDLIPPSPTKSASTQSAPATPRVLIADV
5) WMRGDEGWESTASSPGDDDEPKSDSESEDEELLVDDEGPASALRSSTPPPSYLPLGPT
582
990
376
723
921
628
1028
574
821
978










Molecular Recognition Features






MoRF SequenceStartStop




NANANA