<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07328

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMATTSTSTATSTATTSAHRAAQPQPQPQAHPEPLTLHLTPFTLPAPLLALSPDGEPTYAPKEDGQQRLTRELRRLWARGDYAEVTEAGVGRELQGEGMDVDDQQEEEEDGESVEEGIRPEELWRVKQAVLSKLHEAMQQTLTAQTLLALLSHSAGAAPKPPQRPAMPPPPPPPIPLDGFPTMTATLTTPPGPAPATQLRRRQLAAGLKNASLRRAARLFEAGAGDIERALEKEAHYFERALALREHWRLAPRAAERTPRRRPGKEPARDFAVYYGMEGAPLAQRAAAVAHLSPTSAQGELLFPSRTGRRLRVSLTSLSPGPVPGPGPGLQHLMGSSALELPEQAAEQEHPHGELALGLDLDAQLRDAQREVLEREVFHRLAREAMELVQLSPVIRERVVSLRPLPDLQLTFELVDPSDAPAAGSGQTHSHSRSHSPAVQLLAALLPLLHLPRTRPSLLQPLLKLLQYLQFSAQLTAQLAAVARGLTATGVPTGVQQRLVSADGAQVWKALLGEDAWAIGGEVRLALQGCAPILLAAAYPADLVLHTPRLGVHIAALPELGDVLAGEILARLSAAFQRVGNRVLRAQAAAKADEAEWTLGPGGKGWAEWPTGAVGFRISLSPAFDLAAEAVYSKRAVVREGMSPATPGMGHLESMRREWPEVKQEEDMEQEGRSPPGLVDWFEKGMKWVTEEE
Length692
PositionHead
OrganismCalocera cornea HHB12733
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Dacrymycetes> Dacrymycetales> Dacrymycetaceae> Calocera.
Aromaticity0.05
Grand average of hydropathy-0.333
Instability index54.44
Isoelectric point5.89
Molecular weight74818.18
Publications
PubMed=26659563

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP07328
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     380.66|      94|     132|       2|      96|       1
---------------------------------------------------------------------------
    2-   96 (162.10/61.32)	ATTSTSTATSTATTSAHRA.AQPQPQPQ......AHPEPLTLHLTPFTLP.APLLA........LSP...DGEPTYAPKEDGQQR.LTRELRRLWARGDyAEVTEAGVG...RELQGE
  136-  233 (129.36/45.51)	AMQQTLTAQTLLALLSHSAgAAPKP.PQrpamppPPPPPIPLDGFP.TMT.ATL..........TTP...PG.P..APATQLRRRqLAAGLKNASLRRA.ARLFEAGAGdieRALEKE
  250-  334 (89.19/29.30)	...............APRA.AERTPRRR......PGKEPARDFAVYYGMEgAP.LAqraaavahLSPtsaQGELLF.PSRTG.RR.LRVSLTSL.SPG...PVPGPGPG..lQHLMG.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     228.90|      47|      49|     562|     609|       2
---------------------------------------------------------------------------
  472-  517 (32.10/10.87)	.......AQLTAQLAAVA.RGLTAtgvptgvqQRLVSADGAQvWKALLG..EDAWA...
  519-  557 (51.76/22.18)	..GGEV..RL..ALQGCAPILL..........AAAYPADLVL.HT..PR.lGVHIAALP
  562-  609 (79.32/41.66)	VlAGEILARLSAAFQRVGNRVLRA........QAAAKADEAE.WTLGPG..GKGWAEWP
  613-  659 (65.72/30.43)	V..G.FRISLSPAFDLAAEAVYSK........RAVVREGMSP.ATPGMGhlESMRREWP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.99|      23|      25|     369|     392|       3
---------------------------------------------------------------------------
  369-  392 (34.81/22.81)	RE.VLEREVFHRLaREAMELVQLS..P
  395-  420 (31.18/15.80)	RErVVSLRPLPDL.QLTFELVDPSdaP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.38|      10|      15|     440|     449|       5
---------------------------------------------------------------------------
  440-  449 (17.13/ 7.27)	LLAALLPLLH
  457-  466 (17.25/ 7.37)	LLQPLLKLLQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07328 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EVTEAGVGRELQGEGMDVDDQQEEEEDGESVEEGIRPEE
2) LTAQTLLALLSHSAGAAPKPPQRPAMPPPPPPPIPLDGFPTMTATLTTPPGPAPATQLRRRQLAAG
3) MATTSTSTATSTATTSAHRAAQPQPQPQAHPEPLTLHLTPFTLPAPLLALSPDGEPTYAPKEDGQQRLTRELRRLWA
4) SPATPGMGHLESMRREWPEVKQEEDMEQEGRSPPG
5) VSLTSLSPGPVPGPGPGLQHLMGSSALELPEQAAEQEHPHGELALGLDL
83
141
1
642
312
121
206
77
676
360










Molecular Recognition Features






MoRF SequenceStartStop




1) FAVYY
2) KWVTEEE
270
686
274
692