<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07325

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSGPPRIAARQARPLSPASASSSPKLDDISSRPVFAGPNTPDSPSLMSSTPQNHVPSPAAHQAPSTMTSQPSSQLMDSPPNSSSSKPGSQPIITTTTNTFPTPASSTAGTVPPSTQPDDGDVQMSESDGPPGEVTSHATTGIADDAMAIDRNVSDYTNHERQASVVEPGDGSSRVSGQDKGKGIDQGARHGEELSIEGKIGLERLHADIGQPYLLLKSPHPPTRPQPTQNLISLYGLDPLAATVARKDKFGQKINKLRKSYEGKIKDFNLAGKNKPAKHEEGQPGGLLELVQWPDEEWQNQKLFGKEMTKGLGDALMAKLDKAMTMEPGPIPDDDKWRTVLGLDDDTLRDVSGAGGKKQGLQGVAGGSASQADASTSRGAAAAAAPSPTTPIDRPRRSGKKRSYRESSFAGYGEGYGDDDGELGFSTGDDDDGRRANASKKKRRKDSVGKSPPPLGGRGGSYGVGMVGVGSGIGAR
Length476
PositionHead
OrganismXylona heveae (strain CBS 132557 / TC161)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Xylonomycetes> Xylonales> Xylonaceae> Xylona.
Aromaticity0.04
Grand average of hydropathy-0.811
Instability index46.78
Isoelectric point6.74
Molecular weight49716.34
Publications
PubMed=26693682

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP07325
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.58|      27|      50|       5|      33|       1
---------------------------------------------------------------------------
    5-   32 (36.81/21.81)	.....PRIA..ARQARPlsPASASSSPKLDDISSR
   33-   50 (25.65/ 9.08)	P........vfAGPNTP.......DSPSL..MSST
   51-   79 (42.12/20.05)	PqnhvPSPA..AHQA....PSTMTSQPSSQLMDSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     189.09|      56|      56|     349|     404|       2
---------------------------------------------------------------------------
  323-  355 (31.76/ 7.27)	............................AMTMEPGPIPDDDKWRT..vlglDDDTLRDVSGAG
  356-  411 (95.36/33.78)	GKKQGLQGVAGG...SASQADASTSRGAAAAAAPSPTTPIDRPRRSG....KKRSYRESSFAG
  417-  462 (61.98/19.87)	GDDDGELGFSTGdddDGRRANASKKKRRKDSVGKSP......PPLGG....RGGSY.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.06|      17|      52|     116|     132|       3
---------------------------------------------------------------------------
  116-  132 (34.15/15.41)	QPDDGDVQMSESDGPPG
  167-  183 (29.91/12.55)	EPGDGSSRVSGQDKGKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.91|      27|      71|     206|     236|       4
---------------------------------------------------------------------------
  206-  236 (43.19/37.41)	HADiGQPYLLLKSPHPPTRPQPTQnliSLYG
  279-  305 (52.72/32.28)	HEE.GQPGGLLELVQWPDEEWQNQ...KLFG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07325 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALMAKLDKAMTMEPGPIPDDDKWRTVLGLDDDTLRDVSGAGGKKQGLQGVAGGSASQADASTSRGAAAAAAPSPTTPIDRPRRSGKKRSYRESSFAGYG
2) GYGDDDGELGFSTGDDDDGRRANASKKKRRKDSVGKSPPPLGGRGGSYGVGMVGVGS
3) MSGPPRIAARQARPLSPASASSSPKLDDISSRPVFAGPNTPDSPSLMSSTPQNHVPSPAAHQAPSTMTSQPSSQLMDSPPNSSSSKPGSQPIITTTTNTFPTPASSTAGTVPPSTQPDDGDVQMSESDGPPGEVTSHATTGIADDAMAIDRNVSDYTNHERQASVVEPGDGSSRVSGQDKGKGIDQGARHGEELSIEGKIGL
315
415
1
413
471
202










Molecular Recognition Features






MoRF SequenceStartStop




1) INKLRKSYEG
2) KKKRRKD
3) KWRTV
4) MSGPPRIAARQARPLSP
5) VGKSP
254
440
336
1
448
263
446
340
17
452