<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07318

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAARPHSMAQDTIGTSVLAQCPPTVSLASPILGSIISLPDNPLIAYSVFTSASSQPLRDPLNLIELARRKILSQNAKRHFLDSLLPSVHITKDVSALYVFAFGSTDRTSEAHAALNALQFDGLASTGPTNFTPSAIYPCSAKCADQLTPCTECLTHVPRNLSSASSSAILFPRKPLRLPLHYLLNAIRLRLIDDIATESMLKPRSRRATRLRDGFLLGPSPSASESEWGAGWEHRARGRPLIHAHLDVQLAQTRIVIHPILRPTFYLPLQCPLSVPSGTPITILPHGVPAYYLNTYTGPTSALTTQFEEALLGFGAGDWKGALDMKMQQNGVGASQVDRKVMYVIAWLAVQNKQGEDKGTPIIWPIRLCLAYHPNSPSIHARTPLPYEPELPAQLQASPPPPSVTIPPTLVASAANVATPSSMPESEQLVSPILRRPQMHTYTVSPASESLQAFRNLTLATRPYLRDVQRVAVGASAYVDSVSKERERERERLKRERESAGLRARGPGNNVSISTSVSIPPESTPTIPEVLPLARPVTPVPSVAERLEEPQQPPHEPAEETEEAAPPSSEDSSINSLFSPPADASPSPPIEDEEEEKTGDVQPNNPAEAQMDVDLTEPLVGPSPTEPPANVDRDIVPPLDTFADFDNSWQAGTNDFMDVDMSSYDMEGYNIGMNMGTRGGGAFDIDMDDGFGVFTDDDFNFFDAPAAQSHTPIVSRSSTFNDQGMKVEGLIPASGAMQLGFSPQRMGESVHLSGPGPPSVETTQPSPWPHHAAGEGLTPNLDELLPAPELLAPSPTKTSTTQSAPATPTVQILDQHGVHASHKVSPYALGPSDFDPIPFAPSHKLADSKYLFGKFALPSPPDSEDRLEQVYFPSSAPSVMSGWKYKYNLATDPRIGVVRKLIGIKRKGLEHGVREVHSSPSWAREYEEWESWAPSPTLENSRSDIDSDEDDGWMDDDDATAYSRPSTPPPSYLPLGPTLLQTQFHHARLLPLCAPLRPPGSAGSNIGSSAVPISVPTPVSPAAIMGASSERAKSLEAAAKMLVKEIVENAVWADAWRVNLSASGTSVRTATDVWQADVKGVMSLLDGTGAMQSPISLRALSHPGHSIPVDVSDRTAFCLLEPPMLNVEKSNAVIQVMPSALRFWEKLGLGPRAGKKDVTAYVFFEASGDEREDEVCRWLAKVSATYAARNYGIHMPGSTNNPSKPGLVPVRFEELKKSLANYVATLPRHPGTYLVFYIITPPSVMALRSTVLRNFFTAVKRANKAHPDTDVLYHFAPETLIADEYGDPRLLHRGLEAFVADVYDRILQPVERSMSRRLFAHSMRIRTSLHAPAFALARPTSASSARNTEHVPHVTFAFESRPSSLDVVDRHTMLHAAYTLTPCGRWLVAACVDERGEESAVEAWLVPEESVEAFVVNQVWSFARSFAARANVEWKLVVARMGVIGMNEVDAWIDHLENVVSTSADIPALHVTLLTVDYEQPWSFLAPSRGPLTKSKSPPGSVSARLSPRTQSGAVMIDTSSTTYALFPSTAADPTLCLSSHSASSAGVLNRGAADLSFVPDCEGDELLQRHVYARVPSMSSLIHVPARTDHTTISMVNVYQLHIACSPKSSFRRPSHASVESQKEDGETTTGEEEQTLRDVMHNFHALATLARARWGSRDCHGLPLHLVALEAMSMALSGEPVES
Length1685
PositionKinase
OrganismLaetiporus sulphureus 93-53
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Laetiporus.
Aromaticity0.07
Grand average of hydropathy-0.258
Instability index56.09
Isoelectric point5.61
Molecular weight182987.52
Publications
PubMed=26659563

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07318
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|    1400.13|     269|     270|     730|     998|       1
---------------------------------------------------------------------------
   81-  292 (193.17/76.95)	..............................................................................................................LDS...LLP.SVHI.TKDvSA....lyvfafGST.DRTSEAHAAL..NALQFDGL.A.S.......TG.PTN..FTPSAIYPcSAKCADQLTPCTECLTHVPR....N....lSSASSSAILFP.R..................KPlRLPLHYLLNA..IRLRL........................IDDIATESMLKP.............RSRRATRLRDG..FllGPSP......SA...SESEWGAGW....EHRARGRP...LIHahldvqlaqtrivihpilrPTFYLPLQCPLSVPSGTPIT..ILPHGVPA.YY
  303-  627 (292.02/120.28)	LTTQFEEALLGFGagdwkgaldmkmqqngvgasqvdrkvmyviawlavqnkqgedkgtpiiwPIRLCLA.YH...PNSPSIHARTPLPYePE....L....PAQLQASPPPPS...VTI.PPTL.VA..SAA..N......VAT.PSSMPESEQLvsPILRRPQMH..TYTVSPAS......................ESLQAFRNLTLATRP....Y.....LRD.VQRVAVG.ASA.YVDSVSKERER...ERE.RLKRERESAG..LRARGpgnnvsistsvsippestptipevLPL.ARPVTPVP.............SVAERLEEPQQ..P..PHEPAEETEEAA...PPSSEDSSINSLFSPPADASP...SPP...........iedeeeekTGDVQPNNPAEAQMDVDLTE..PLVGPSPT.EP
  730-  998 (457.87/192.99)	LIPASGAMQLGFS.................................................PQRMGES.VHLSGPGPPSVETTQPSPW.PH....H....AAGEGLTPNLDE...LLP.APEL.LAP.SPT..K......TST.TQSAPATPTV..QILDQHGVHA.SHKVSPYALG.PSD..FDPIPFAP.SHKLADSKYLFGKFALPSPP....D.....SEDRLEQVYFP.SSAPSVMSGWKYKYNL.ATDP.RIGVVRKLIG..IKRKG........................LEHGVREVHSSP.............SWAREYEEWES..W..APSPTLENSRSD...IDSDEDDGWMDDDDATAYSRP...STP...................PPSYLPLGPTLLQTQFHHAR..LLPLCAPL.RP
 1002- 1229 (224.22/90.56)	............A.................................................GSNIGSSaVPISVPTPVSPAAIMGASS.ERakslE....AAAKMLVKEIVEnavWAD.AWRVnLSA.SGTsvR......TATdVWQADVKGVM..SLLDGTGAMQ.S.PISLRALShPGH..SIPVDVS...........DRTAFCLLEPPmlnvE.....KSNAVIQVM......PSALRFWE...KL.GLGP.RAG..................................................................K..KDVTA..Y..V...FFEAS.GD...EREDEVCRWLAKVSATYAARNygiHMP...................GSTNNPSKPGLVPVRFEELKksLANYVATLpRH
 1231- 1481 (232.84/94.34)	..................................................................GTY.LVFYIITPPSVMALRSTVL.RN....FftavKRANKAHPDTDV...LYHfAPET.L...............IAD.EYGDP.......RLL.HRGLEAfVADVYDRILQ.PVErsMSRRLFAH.SMRIRTSLHA.PAFALARPT....SassarNTEHVPHVTFAfESRPSSLDVVDRHTMLhAAYT.LTPCGRWLVAacVDERG........................EESAV.EAWLVPeesveafvvnqvwSFARSFAARANveW......KLVVAR..mgvIGMNEVDAWIDHLENVVSTSA...DIP........................ALHVTLLTVDYEQ......P........
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07318 with Med13 domain of Kingdom Fungi
Unable to open file!