<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07310

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMADGLKGAPNGAIPNGDVPETTGLQEAPAEIEHITMGYQPLSRLVSRLAQETFNNLGEVVNAMSELTVSKPAGQMSSAYGNHVNGNANVSAANVEKKMLLMRFAQARRDQFIKTLVLSQWSRQAGDVSKAIDLKVWLDRQRALYEEAGAWMGELKRNLEPAKMPNPDLRTALEVLSTGKASWMPDLGYLPPDPLTPEEMLKTLRKINTLLSIRLNLEETLPPHFKTFTVADGRATFTVPSEFEVDVSIAEEDSSSQFYFIDFRFLFKPSPTELPDGRIRAQLEGKANDVLKNEGLAGLYLFLHEFVLTHKIGVLRRQALEMSRGNWTESVRLEIVRRTLVLQYWTNRPGGKSWIEIGIKSGRLKEGKLLPGEESTSYLDIRWMRENREVKEIPITFDSANLSMEAILNKAIALHTTYILSSMHSRLSTLALFAQKSLALSLSTSDTEPMSCSLQVQLTATETATILVEPTTGRFALNPPSLLFGRAEYELNRIVNPAADAFMPIANLRCLAVEQEVETRARCVGWKILKTMNLKQEEMKRIFPRDTLRISFFRRDGWLENFILAVSISMAGEIWWIAEIYQNDSGYSVNNAIRIPIRSETPNVPPTSYSFLCRLEGVAASMISHYVNTRDLARRGVAHSLRPPSNSSSSTSSSENSSLAGQIPTLFVQLSSLLCSPESSLRPTVQTTWAKDVLRISYSGTSIEDGKLYSTIEARLKEPLPGVDIINDRLDEDVVFHPKTGAFAFQLKTPVGTSIIDPIITRLKRIGRLTRFVDVVRRIKLKCETISLSRIVFVYNTTPLLLKADIGLGTDGTMSLNLDKGNPHLLIKDFLLAFLNNDNGLEHVTLLLRLTAPLVLALDKISRNVNAIVLPRSIDHYHVRYSNPPCTISIRLRQRRDENKWFISDASDQNTLESRKPEFKEALKDLFMSDGPDWKGLRTGIATGMMAVGDVLDQLDNLVRRFQQNSPPTASDAAGINQTATAGKDKPGPNAKGSNPQPNNKKDNVVVLD
Length1008
PositionTail
OrganismXylona heveae (strain CBS 132557 / TC161)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Xylonomycetes> Xylonales> Xylonaceae> Xylona.
Aromaticity0.07
Grand average of hydropathy-0.241
Instability index43.20
Isoelectric point8.53
Molecular weight112357.46
Publications
PubMed=26693682

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP07310
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     319.62|      86|     373|     468|     557|       1
---------------------------------------------------------------------------
  153-  209 (59.69/29.82)	.....................EL..KRN...LEPAK...MPNPDLRT...ALE..VLSTGK.ASWmpdlGYLPPDPLTPEEMLKTLRKiNTL.......
  251-  337 (117.26/63.65)	EDSSSQFYFIDFRFLFKPSPTELpdGRIraqLEGKANDVLKNEGLAGLYLFLHefVLTHK..IG......VLRRQAL...EMSRGNWT.ESVRLEIVRR
  468-  554 (142.68/92.83)	EPTTGRFALNPPSLLFGRAEYEL..NRI...VNPAADAFMPIANLRCLAVEQE..VETRARcVGW....KILKTMNLKQEEMKRIFPR.DTLRISFFRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.77|      18|     221|     114|     138|       2
---------------------------------------------------------------------------
  114-  138 (27.44/24.49)	TLVLSQWSRQAGDvskaidlKVWLD
  338-  355 (36.33/18.25)	TLVLQYWTNRPGG.......KSWIE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07310 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NLVRRFQQNSPPTASDAAGINQTATAGKDKPGPNAKGSNPQPNNKKDNVVVLD
956
1008










Molecular Recognition Features






MoRF SequenceStartStop




NANANA