<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07304

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMVDPSSAPSAQAHAHAQAQEQNGLPSPSPQASHMNGHLLPASKHLPPPDPDALAGKTEKLGGGGRASPPPLPHELTDMIPLREVVSRLVQKAYEDLQNLVEVLPSKSDTERKHLIREYGSSTRKQAVKTLVLTRWARDAPIVQKCQDVRFFLQLQNGQFREAAHALDGVRRALGAARSRAWDVLTAVDVLASGSYLRLPTVIKEWFLPPARITPAAALATLHAMNRSLRLRLRTAEIVPIEMARYRVADGRVYFTVPELFAAAFVTGGAERSQLWYLLDVEFLIGARDPTRVFERFPRRPQGAMRDQIISLVNQQLALGHDALPAPDEAEPAHGRRRRRARVVTVDAPLVRAYNFLQMFALGYQLEILYYQASLLVSSLGWAPYLRLEFSRDRRTLTASYWQKARAPPPPGNPPWPASQSKVFGGTVTVSLESRASQGRSALGQVLAELEDRSKAGYGGGAVVVRTRDKVDGLRLRVIWEPARAWAGLTLPEHQLRGDEFDVDPRDLDFEAVLARVISRHADALLRVWFAQMRLGASKTVFREEEIALVQAEGAADGTLEMHVHFRPGEVTLLSLDVRSGAFVARERGVLPSVSRSDKIAMLVRQINDKPTTFVEAVCMTRFTILLEDLEKRASVLRTNVSKTRLVRAQDMPAFGPSARLFLYIALAAFPSHYLVLVLADSGLQYAMLKVALVNEDVAPEFQILECAWLDIRRITGADPSAPDRRWAISTDALCDLYAFCRARVAHAELEQQLRDVKIASWPTFDSPSAAASRIETLPFASPLLQKEVPTIRIESSAFLGAMSSDASTMSADAWCAYIAFRAINWTRLYGPVGVIVSVALRSEFFVPLADEKSTTGEYAGVRVKLDSKTGVINFHLESVHGAIVAFLRAWEGVSKAVSVAREVRTMSQEPRYAGVQLLSFTLSSVSLLYQNSFALTISSHGSTSLVFSYHGTPGRRNPHEEGIEHYSRVFEESGPRKLIEILRDTLPLLLEFDQLEKSASIKMRWVLREAGWVRALYGDARHALDFRLLPNSRILVVDGAIHLFNPNGKVVFPQHPVISLMRESTQKFSSLYQVIDGLPTLLLDVTRSVAKERAGMASAVAGKNKLPDVVPLEAGLMCHQDVVRSVVRLVHEGTLKLLEGEGA
Length1143
PositionTail
OrganismCalocera cornea HHB12733
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Dacrymycetes> Dacrymycetales> Dacrymycetaceae> Calocera.
Aromaticity0.08
Grand average of hydropathy-0.086
Instability index48.28
Isoelectric point9.21
Molecular weight126529.83
Publications
PubMed=26659563

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07304
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      80.16|      20|      47|     419|     438|       1
---------------------------------------------------------------------------
  419-  438 (33.56/23.89)	QSKVFGGTVTVSLE.SRASQG
  443-  456 (15.56/ 6.09)	......GQVLAELE.DRSKAG
  467-  487 (31.04/21.41)	RDKVDGLRLRVIWEpARAWAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     374.63|     144|     359|     518|     677|       2
---------------------------------------------------------------------------
  246-  375 (137.52/78.85)	RVADG..RVYFTVPELFAAAFVTggaeRSQLWYLLDVEfliGARDPT.RVFERFprRPqGAmrdqiISLVNQQLALGhdALPAPDE.AEPAHGRRRRRARVV..TVDAP..LVRAYNFLQMFALgyqLE..ILYYQASL.L.........................................
  519-  677 (208.32/176.55)	RHADAllRVWFAQMRLGASKTVF....REEEIALVQAE...GAADGTlEMHVHF..RP.GE.....VTLLSLDVRSG..AFVARERgVLPSVSRSDKIAMLVrqINDKPttFVEAVCMTRFTIL...LE..DLEKRASV.LRTNVSKTRLVRAqdmpAFGpSARLFLYIALaaFPSHYLVLV
  989- 1037 (28.79/ 8.43)	...........................................................................................................................L...LEfdQLEKSASIkMRWVLREAGWVRA....LYG.DARHALDFRL..LPNSRILVV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.46|      32|     737|      12|      45|       9
---------------------------------------------------------------------------
   12-   45 (56.34/37.42)	AHAHAQAQEQN....GLP...SPSPQASHMngHLLP.ASKHL
  745-  784 (43.12/22.21)	AHAELEQQLRDvkiaSWPtfdSPSAAASRI..ETLPfASPLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07304 with Med14 domain of Kingdom Fungi
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