<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07303

Description Kinase-like protein
SequenceMQHQTDTMRAYRARKDASRRSVVSKYTILGFISSGTYGRVYKATGKDDGRAYAIKKFKPDKEGEVTTYTGISQSAIREIALNREIAHDNVVALREVILEDKSIYMVFEYADHDFLQVIHHHSHTLRSGIPTAVLKSLTYQLLNGLLYLHNAHILHRDLKPANILITAQGVVKIGDLGLARLAHQPLQPLVQGDKIVVTIWYRAPELLLGAKHYNKAIDNWAVGCVLAELVSLRPIFKGEEAKMDSKKTVPFQRDQILKIVEVLGTPDERTWPGIVYMPEWHSMSQLDTYQNQLHQWCSSHNRLRSPSGIDLLKKMFEYDPDKRITAQDALQHKWFTEDPKPSRNVFQTISQSQCPPPRRLSPDDAPSMVAPSVAAASMSRPASGIPHSRLEANRVGPSVPPNVGTVEAPSRKKRRLE
Length417
PositionKinase
OrganismExidia glandulosa HHB12029
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Auriculariales> Exidiaceae> Exidia.
Aromaticity0.07
Grand average of hydropathy-0.424
Instability index49.31
Isoelectric point9.48
Molecular weight47028.39
Publications
PubMed=26659563

Function

Annotated function 
GO - Cellular Component
euchromatin	GO:0000791	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IEA:EnsemblFungi

GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07303
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.73|      23|      24|     369|     391|       1
---------------------------------------------------------------------------
  369-  391 (39.32/21.83)	VAPSVAAASMSRPASGIPHSRLE
  395-  417 (40.40/22.60)	VGPSVPPNVGTVEAPSRKKRRLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.38|      19|      27|     120|     145|       2
---------------------------------------------------------------------------
  120-  140 (29.79/28.46)	HHSHTLRSGI.PTAVLksLTYQ
  149-  168 (29.59/11.41)	HNAHILHRDLkPANIL..ITAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.93|      18|      29|       9|      26|       3
---------------------------------------------------------------------------
    9-   26 (30.75/20.40)	RAYRAR.KDASRRSVVSKY
   39-   57 (27.18/17.26)	RVYKATgKDDGRAYAIKKF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07303 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NVFQTISQSQCPPPRRLSPDDAPSMVAPSVAAASMSRPASGIPHSRLEANRVGPSVPPNVGTVEAPSRKKRRLE
344
417










Molecular Recognition Features






MoRF SequenceStartStop




1) GIPHSRL
2) YAIKKF
384
52
390
57