<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07299

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMASKSATTTSDVLLSFLKLPPETVVLCASYAPIGDQATHALAIDNARRLIHNSRDPSSPFQPLLAHVDVQQHDSRLAVFAIASKPAHSPHAHALRSLALHNLVAVDTSSFDFHMLYSNRRNDSHSPTTAFVTPGLHRLYLMFLAALRDRILADICDTYSDRIRASCVRLRDGFLLIHRPLDSEWAFGWDDPQSRLAHCRLHLHWMDASTIVLRPIFTTVPYARLSAKRAIAGTPIALLPYDVPAYFIAPYTGSTAALSQQFRDSLVGLGVGPSWERRGYILCWIPVHASQNEDKAVLAVWPTALAVACTDRPHAKRLPTVPDHFAIPSWQTHDKQPRTARARAVIPVVTKHSSDVPSVAVNVAGFVDAMAREREREREKAKEERYRRLNVSVPQSGVVGGPRSTLSGSAGGFAQSMSASDHFPSPGLPLSQFTSPPNDVPAMPPPPVWGAPQPDVPIAAPASSFPSVDDFYSALGATDDMASFGLLTEDDFSFFDQPAVPVPPAEPPPDHSANLLDDAAAQADIIMSIDDFTQQLESHDGMGMPLYGTGWTPEYAPDPPRTAQFTDMLTGVLPSPAKTPWTPAPEPATPSLVFAHDPATVVVDPFDQIPFAVAHSAADAKYTAGKFSATLSVPLSPAPSPPTRDLRERYRTLTNPSVGVVQRLRMAKRKSIDQGRRASPSPWERSEAEWIVNPPSPDGLPSPPSSDADSSDEEPKDDLFGDDYEDEELAADATQARAPTPVPDAVLIGPALLHAAFAHRALLPLGVPLPPPGSSAPTPAGAQPISVPTPVSPAAAGAGATPFERARSLEPVATAFAREVVENATWAAAWQMLAEKKEKEREVWQEEIGQSVALFGALPYLAVGSSGWSVTQLAPPEIVLEKGGILVPVAPTALRFWEKMGFGPRAGAKHVSAFVLYEDGSAVAASVAPWLESVSKAFASRGLGTHVAGKAGGYELSVPLKWELFRKTLAHLVTAMAASPSTTASSHYVVFYIAIPQSMMTLSSLFLRNILGVAAQHMKLPNGAVLDPDRMLIHLLPEAAILDSSLFPVTSVVGSVYDRLPRIVERHAARPFFKRGLAWRSAFDAASFTLARRPGQTKVNLQWDWPIRHLDVVEKNTFLHVAYRISQCRNWVFFAATDERGESHSLMTWAYSPDTTLLELVQDVWKRAMDLAGRASVSWRLVIAKSGSMGREEYEAWVSHFDNKVKASKEQDTPDTQAPDVQITLVGVHRAAPFTLLPLSLATDDSIVPAQDERPSASSYMTDVSWRGYMLDPPATQPLSDIVETTPAAAGEWSLRDGASVTAASDDGVVPAATVTLLRSSAALKKPAMSHVHLFHLSHSTGRPLAPDVVPAEHLRDIVRNYGELSVLGHVRSYGASSGPPVLPLHLAAVEHMDRTFAAADMVLEVSGNVVDRDV
Length1414
PositionKinase
OrganismExidia glandulosa HHB12029
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Auriculariales> Exidiaceae> Exidia.
Aromaticity0.08
Grand average of hydropathy-0.122
Instability index49.51
Isoelectric point5.93
Molecular weight152955.59
Publications
PubMed=26659563

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07299
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     327.22|      58|      59|     393|     450|       1
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  393-  448 (102.76/43.10)	..............PQSGV.VGGPRSTLSGSA................GGFAQSMSASDHFPSP................GL....PL................SQFTSPP.NDVPA...MPPPPVW
  449-  508 (79.04/31.42)	GA............PQPDVpIAAPASSFP.SV................DDFYSALGATDDMASF................GLltedDF................SFFDQPA.VPVPP...AEPPP..
  510-  580 (33.38/ 8.93)	.............................HSAnllddaaaqadiimsiDDFTQQLESHDGM...................GM....PLygtgwtpeyapdpprtAQFTDML.TGVLP...SPAKTPW
  582-  643 (68.47/26.21)	PApepatpslvfahDPATV.VVDPFDQIP.....................FAVAHSAADAKYTA................G.....KF................SATLSVP.LS.PA....PSPPTR
  644-  719 (43.59/13.95)	DL...reryrtltnPSVGV.VQRLR...MAKR................KSIDQGRRAS...PSPwerseaewivnppspdGL....P.....................SPPsSDADSsdeEPKDDLF
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.62|      35|      39|    1308|    1346|       2
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 1308- 1346 (50.47/37.77)	VVPAATV.TLLRSSAALKkpAMSHVHLFhlSHSTGRPLAP
 1348- 1383 (58.15/31.06)	VVPAEHLrDIVRNYGELS..VLGHVRSY..GASSGPPVLP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.20|      33|      39|      87|     119|       3
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   87-  119 (60.15/41.08)	HSPH....AHALRSLALHNLVAV.DTSSFDFHMLYSNR
  124-  161 (51.06/33.57)	HSPTtafvTPGLHRLYLMFLAALrDRILADICDTYSDR
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.85|      15|      43|     738|     757|       4
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  738-  757 (19.64/16.80)	PTPVPDAVliGPAllhAAFA
  783-  797 (28.21/11.18)	PISVPTPV..SPA...AAGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.62|      36|      43|    1201|    1242|       5
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 1201- 1239 (53.06/38.78)	DNKVKASKEQDTPDTQAPDVqiTLVGVHRAAPFTlLPLS
 1244- 1279 (66.56/31.95)	DSIVPAQDERPSASSYMTDV..SWRGYMLDPPAT.QPLS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.27|      18|      44|     994|    1011|       6
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  994- 1011 (31.54/16.85)	IPQSMMTLSSLF.LRNILG
 1035- 1053 (24.74/11.83)	LPEAAILDSSLFpVTSVVG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.32|      22|      44|     280|     301|       7
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  280-  301 (40.72/21.84)	ILCWIPVHASQ...NEDKAVLAVWP
  306-  330 (34.60/17.39)	VACTDRPHAKRlptVPDHFAIPSWQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.22|      12|     117|     805|     816|       8
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  805-  816 (21.22/ 8.41)	ARSLEPVATAFA
  927-  938 (23.00/ 9.63)	APWLESVSKAFA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.83|      16|     117|     228|     255|      12
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  236-  255 (26.61/28.46)	ALLPYDVPayfiAPYTGSTA
  760-  775 (32.23/ 8.81)	ALLPLGVP....LPPPGSSA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07299 with Med13 domain of Kingdom Fungi
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