<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07295

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMSLSELTRNSFQSGVSAKKWVNLCKLFLTNNNIHAASDDIQSSISNSVLILFHNYPGDPGLQAYLKYAIQDGLLSLAKFVSTFLSAARSLELHNAATLDMLCRVALDSHYESGIPPIGSLVAYSESAMEVMGTVQDAMALIRTAHSLPMSHFHQLTTSASELLVLLLSCAVDVSQVSTAQASMLFMDAADLLQTVRLAPAVYQKLESFVGSIHKVLVDGEKAAREEQIMQTLHLATGKSSLDVGPETDPVTLGLMFHSIITARAHAFGAGDSKNMTALLLAWVRWSSWSPAVFYSQLLLSAITCLAEQQAIGAPHSTALLWRSFVIGRLPFLLSMLQKVAESTGSAETDWQPAFKLALTTVLRRSDVIEKCDANQHFGHDMGVSKATTPRPFVLEFLHQSQSAGLIDSSYAATLHPELLNDFRSRLETEAQDAGMNMKSYFETKLAADTNIDDASALLERMCADPCSHAVFAHVVEKRVRALVGTLDVEPLSFLCKAFYRCEAALDILSLHIRISDFVACILAFIEDYDCETVGDPQTAVSHLGEVVLFVQETIARFDLTRTEFVLDERRLSLDIYKTAARVRPMTALNAEETNAFHAWYKALFDTSSEGIEDTILRNTRPRTLLRITATLFAHAITMCARRRIDKDVLNNGISYFLGVLLNWTLSGIVKSLLVIVQHEGLDPSLHLEVLQTLVLSTLCPRTVIRLSASSLLRAFPAHKQERAKIPALDTAPIRRVALESLNLPVEESNRTSLSLGSQNSSWTDVTAQAISTVLSAAQAGKAHGLDVDRALVVTSPTTFLHLLWTECMKNMNMGSIEAAKRVATFVLVMPRRPRSPPLLPIFLHGLLPGLVAAVDTHNTADFQSPADAHNPAQQAMTVELIGAIVSSALTAALHLEWALHTACDEQRPVLGHSATAMARRLGSDLRNKSHGPTSAILVQRLASSPSFMTNFPTFMAA
Length957
PositionTail
OrganismLaetiporus sulphureus 93-53
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Laetiporus.
Aromaticity0.07
Grand average of hydropathy0.152
Instability index45.92
Isoelectric point6.14
Molecular weight104557.04
Publications
PubMed=26659563

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07295
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     199.87|      65|      90|     315|     379|       1
---------------------------------------------------------------------------
  315-  379 (113.66/82.50)	HSTALLWRSFVIGRLPFLLSMLQ.KVAESTGSAETDWQPAF..KLAL.TTVLRRSDVIEK.C.DANQH..FGH
  401-  473 (86.21/60.52)	QSAGLIDSSYAATLHPELLNDFRsRLETEAQDAGMNMKSYFetKLAAdTNIDDASALLERmCaDPCSHavFAH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     176.80|      55|      91|      73|     162|       2
---------------------------------------------------------------------------
   73-  127 (91.53/144.95)	LLSLAKFVSTFLSAARSLELHNAATLDMLCRV..ALDSHYESGIPPIGSLVAYSESA
  166-  222 (85.26/56.41)	LLSCAVDVSQVSTAQASMLFMDAADLLQTVRLapAVYQKLESFVGSIHKVLVDGEKA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.76|      42|      91|     763|     804|       3
---------------------------------------------------------------------------
  763-  804 (69.51/36.89)	TDVTAQAISTVLSAAQAGKAHGLDVDRALVVTSPTTFLHLLW
  856-  897 (72.26/38.60)	THNTADFQSPADAHNPAQQAMTVELIGAIVSSALTAALHLEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.39|      14|      96|     488|     512|       8
---------------------------------------------------------------------------
  491-  506 (21.86/38.00)	LSFLCKafYRCEAALD
  522-  535 (26.53/ 6.40)	LAFIED..YDCETVGD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07295 with Med5 domain of Kingdom Fungi
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