<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07289

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMEPNGVNGHIVHITDGPSHINSTHEPTVEELEHALPMVQNDMIPLGELLSRMAQTIYAELSELAETLPNMSDTARKRTLADWVVATKKQVVKLYAVVKWSRDAGIVQKAMNITTFLMEQNNQFLRAQDVLLTHRDTLNAARMRNHDLLTSLDVLTTGSYRRLPSKIKRLVIPPIPLTDDEVKHTLEDVEDAIRFRLRMIEIIPPEMSSYRIADGRVSFFVPKLFEVSLCLRGAKKDDGWFFVNVEFLFNIGGDRTGLQAEFPRKPVGILRRHITDEADARLAFYLPLPPDQPPLPPGVEIPPRPQLPEGITDAPLVRVYNMLQMMSLSYQLEILWFQAERLRSLGWADFLTVEMTNSRQTMVVSYWIRKPPSKIPGRQPPPIPLLGGRLTISIVRVPAAKNNKDNRSPKARVLAELQEKAKLDVKRPSDEVEPLQFEVKWEPVVNALGISVPAQDIHLSQAELAIDSDNLDFESLLRKVLAKHSEAILKVIQHQLQNGNETRAMFSPPGEITLVVDEGLLALRTHLCADEVVIITIDPRTGQLNLRDMGDLAAAGRGRRYAFITAMVNMDPRTLPYRLLVLKRNTIIDNARQKANYIGLQTFSTRNFPPEELSKIGRSREDMLYIQLAKFPNHYLVLVIADEDFRYALISVEVQQNENDMFPQMAMRDVGWLDVKRIHGDEIIVAHADGADAGVVGQKRKRGLHDEGEHLRSIEQYTRRFNLETHTLREIYAFCCARVAYTKIEQQFKSRSIPYTTVDASNIAKIPELALVQSTLTRSIPALCVQSSDILSGAPAAEAAMPNIRIIPLHWWSENQAQVVTCVKLKYVQQPIGKRASSSSSIIRPSKRIIYDTTEAIVSFLSEDVDKCVDEFLEEWGRVSKMVVVAREVAQMSQKYRWSDVRLLSFDLQTVEFAYSGDYTVSITCVDQLSLTGGSYELTFSRVSDTDTIGQKPPDGGSSYNPHEDLEPYLCTLLRHGRLSASLHTLVALLRDTLPIVLELEDIRSATSRSGDNVDVFPKSAYWFRILYGDLRHALDFRLMTEGRVLVMDGAFSLFAAEDSSGKLVGLNNQSPSKPTPLYRSAPDRAADTSLLLQPIADFPAMISEVLKSVGSAGVSGRVTPIDIGMICDAPAVRAVGKALHDRILQRLAR
Length1149
PositionTail
OrganismLaetiporus sulphureus 93-53
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Laetiporus.
Aromaticity0.07
Grand average of hydropathy-0.185
Instability index46.64
Isoelectric point6.38
Molecular weight129023.85
Publications
PubMed=26659563

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07289
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.36|      35|     119|     172|     211|       1
---------------------------------------------------------------------------
  172-  211 (54.23/51.43)	PPIPlTDDEV..KHTL.EDVEDAIRFRL.RMIEIippeMS.SYRI
  292-  331 (48.13/30.31)	PPLP.PGVEIppRPQLpEGITDAPLVRVyNMLQM....MSlSYQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.36|      13|      24|     750|     762|       2
---------------------------------------------------------------------------
  750-  762 (24.03/16.02)	RSIPYTTVDASNI
  777-  789 (24.33/16.31)	RSIPALCVQSSDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.00|      24|      30|     574|     602|       3
---------------------------------------------------------------------------
  574-  602 (35.65/36.79)	LPYRLLvlkrnTIIDNARQKANYIGLQTF
  607-  630 (42.35/29.90)	FPPEEL.....SKIGRSREDMLYIQLAKF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.62|      36|     250|     691|     727|       4
---------------------------------------------------------------------------
  691-  727 (59.94/44.26)	DAGVVGQKRKRGLHDEGEHlRSIEQY....TR..RFNLETHTL
  944-  985 (55.68/36.21)	DTDTIGQKPPDGGSSYNPH.EDLEPYlctlLRhgRLSASLHTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.89|      14|      23|     119|     132|       5
---------------------------------------------------------------------------
  119-  132 (24.15/17.77)	QNNQFLRAQDVLLT
  143-  156 (23.74/17.33)	RNHDLLTSLDVLTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.29|      34|     254|     393|     431|       6
---------------------------------------------------------------------------
  393-  431 (42.50/32.25)	IVRVPAAKNNKDnRSPKarvLAeLQEKAKLDVKR.PSDEV
  648-  682 (57.79/28.08)	LISVEVQQNEND.MFPQ...MA.MRDVGWLDVKRiHGDEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.30|      27|      29|      10|      36|       7
---------------------------------------------------------------------------
   10-   36 (46.78/35.98)	IVHITDGPSHINSTHEPTVEELEHALP
   42-   68 (43.52/32.88)	MIPLGELLSRMAQTIYAELSELAETLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.74|      12|      23|     213|     226|       9
---------------------------------------------------------------------------
  213-  226 (19.19/19.84)	DGRvsFFVPK..LFEV
  237-  250 (20.55/13.07)	DGW..FFVNVefLFNI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07289 with Med14 domain of Kingdom Fungi
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