Description | Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MTEEPPYKKLRLSLEQPYKDDGGERILQLLDIAPDGERVYKPREEPVARLGDNLTRVIRERGIDFFEKYKPDGAWRDAEPSEANASDSDTDVEADAAKSKTRDGDDKQRPMSVDELHAMRTEMIPHLYTAMGEMSLARDLLALVSSATPSGPLAPLAQPSPMPNLPAGTLTGSTVSNPPPLPSVAQFNAQLTLGAKDKALRQASDVLRNAADTMERTRKRDESYWVDALTARAANWSLVPAPLPPGAPTGKNADKTARDFIISFGLEEAPMEFRRRAMAYLSAVDNDGSPLVFQHRQKMRLRIALSREEADGTKNVSYNSLHAPDDSDVNSILKYAQQELIEQEVFHELFREAEKFPSGDTRVSERLISVSVAHTMQLSFTLVPSATCNNSDEEPSSPLCDLIHAALKLLLLRRHSFVKKQRSSTSTSLTASTTAPIQAPPPKILQPIIDLIQYQSFCDRIANELRKVCAALWAVGVHAKMRMTRVGESGNDLVALLDSPDGSIGGEAVLRVAHRPTFRLTFQSPAMLVAQTSQANVTISSIAQLAQVLHDEVKLAVLERICDIGKATCGDPKALWFVDGVSSRTMGRWGGHSATFQMSLESGAVVADAWTIRSGVTTAVNVAYSPAAGQLLDWATGIVRNLSAQ |
Length | 645 |
Position | Head |
Organism | Exidia glandulosa HHB12029 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Auriculariales> Exidiaceae> Exidia. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.314 |
Instability index | 45.08 |
Isoelectric point | 5.84 |
Molecular weight | 70471.09 |
Publications | PubMed=26659563 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP07282 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 172.13| 55| 76| 482| 538| 1 --------------------------------------------------------------------------- 482- 538 (85.38/57.24) RMTRVGESG.NDLVALLdSPDGsIGGEAVLRV.AHRPTFRLTFQSPAMLV.AQTSQANVT 560- 617 (86.76/50.01) RICDIGKATcGDPKALW.FVDG.VSSRTMGRWgGHSATFQMSLESGAVVAdAWTIRSGVT --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 43.83| 11| 76| 161| 172| 2 --------------------------------------------------------------------------- 161- 172 (19.19/14.21) PMPnLPAGTLTG 240- 250 (24.64/13.46) PAP.LPPGAPTG --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ERILQLLDI 2) IDFFEKYK 3) PPYKKLRLSLEQPYKDD 4) RVYKPR | 24 63 5 38 | 32 70 21 43 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab