Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MTSHKSTREVLLTCIDEIEIIAKELLDNLIAQKQQKPVSAEHSQLVELVLQKDTDLKATLKLAEEQGVLQQKVVALETEVERHDIEIRNLQKQLKEAEQLLATAIFQAKQKLQAIAKANSRPVNSEELIKFAHRISASNAVCAPLNWQQGDLRRPYPTDIEMRLGFLGRLGEMNVNGHISFPELLHRPNHSMQQGSSVPNSQAGTYSWLSQNDLQMPGLSVSHLGVGGGMDHKTPKKENEDVDVMSTDSSSSSSSDSQ |
Length | 258 |
Position | Middle |
Organism | Daphnia magna |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Crustacea> Branchiopoda> Diplostraca> Cladocera> Anomopoda> Daphniidae> Daphnia. |
Aromaticity | 0.03 |
Grand average of hydropathy | -0.506 |
Instability index | 58.76 |
Isoelectric point | 5.73 |
Molecular weight | 28621.02 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP07267 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 98.17| 30| 32| 124| 155| 1 --------------------------------------------------------------------------- 124- 155 (44.56/41.48) NSEELIKFAHRISASNaVCAPLNWQQgDLRRP 159- 188 (53.61/38.54) DIEMRLGFLGRLGEMN.VNGHISFPE.LLHRP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 75.78| 27| 33| 34| 65| 2 --------------------------------------------------------------------------- 34- 65 (35.41/40.36) QQKPVSAEHSqlVElvlQKD...TDLKATLKLAEE 70- 99 (40.37/28.81) QQKVVALETE..VE...RHDieiRNLQKQLKEAEQ --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AGTYSWLS 2) PKKENEDVDVMSTDS | 203 235 | 210 249 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab