<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07264

Description Mediator of RNA polymerase II transcription subunit 12 protein
SequenceMDVLTQVDVQDNSIHHNLAVLFSVLLARHCFGLQDFLLYVGVPSLVKIWNEGGRSDTDPEAEAGARLTCHLVLRLFKTSDAPHPACYSSSSHSVNASPHHTLQQTATSSALGVKLACDRHLLAATHNSISVGPVLAVLKAILVLADRVPPEGKGSRVTGSSGGMNSNSNRLGGGGNAMANEVSISHILGTSWSGDLDLDIGSANFGVGGGRNSFGVATENVPLASYARYVLRQICSQPWVHQRCLQNPEELLKLDGLLDSCLSLRQAQRLLQMISRPDSGATAADEHTNNEHQDYRQVVNRVLESLDQWRLRVAWLDLQLLCQQLTTVGSGGTSSADMNQLLEAIARAVLDVFELSTTSSIKEDPDQGGSSSALKKRSESAATVASSVSATPAKTQPNLSISLIAPLVSKLPGSVQGRILKVASQVLEICNWGPPSKGKDKERNIPNTTSAFRSKSLLSYEPLLSLVMTCLKGQDEQREAFLSSLHSQLSHFIFLPKEDRLYHGEDVKARQAMLEALQLRFSLVGGLFDSILRNPTVVIDWAILLTQLVTAGVVDLSNNTELFATLQDMLATLLHSTLVTDGQSERGEDSRKYYPLLIKKLKKELAERKSSPSIQCIKQLLPLPKLASEFVTCEPYGTLTDIKGNKISGFDSNDKKQGHRLHEKQRVSPWEILEGHKTVAPLSWAWFGAVRVERKPLRHQEVQRLLRHHTHALQKPASYYLEHPLLPPEDLEPPVIEKTIPKEEICFKTEPMSDQSPRGGTKRGQKTNQRRPRGRRGAAAAAAAAAAATVAGAPPAVGGYQSPVASGMYPPSQPPPQWNAYTSPAPPASQQGTVPTSAAFFPQQSIGPRFPTERPGTQSRQALSNMLRQRHPGTQFVPASASNPSGTNPVAVPNAPPTAGGGGGTMANNSRIAGGVGGVGAGGASQPQFAGISMVDKQRQQQFIRQQIRQQHTGGNVFGQQGPQQTQPQQQQPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQVQMAPVGFANIHTPMNQNMNQNMNQNFNMFQSGAPGMQQLVNPQQQAQPQPTQQQQPQQQAMIGQHFNQAGGNFPMQQTQPQGNMILMQQQHQQPQGRGMNAPAMRPPFMQSGGMQINSAQPNQFVRGAMPNTSQQQAVRLQHQQIVAIQQQQQMQHNMGQQQHNQHYHQPF
Length1175
PositionKinase
OrganismDaphnia magna
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Crustacea> Branchiopoda> Diplostraca> Cladocera> Anomopoda> Daphniidae> Daphnia.
Aromaticity0.05
Grand average of hydropathy-0.536
Instability index57.85
Isoelectric point9.25
Molecular weight128392.27
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07264
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.52|      15|      15|     969|     983|       1
---------------------------------------------------------------------------
  969-  983 (35.37/12.12)	QQQQPQQQQQQQQQQ
  986-  999 (32.16/10.34)	QQQQ.QQQQQQQQQQ
 1051- 1064 (26.99/ 7.48)	QPQ.PTQQQQPQQQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     251.50|      36|      40|     807|     842|       2
---------------------------------------------------------------------------
  724-  751 (24.93/ 6.80)	.....PLLPPEDLE..........PPVI..EK.T..I...PKEEICFkteP
  764-  801 (39.41/15.54)	G.Q.KTNQRRPRGRRGA....AAAAAAA..AAAT..VagaPPAVGGY...Q
  807-  842 (68.08/32.86)	G.MYPPSQPPPQWNAYT....SPAPPAS..QQGT..V...PTSAAFF...P
  847-  884 (42.86/17.63)	GpRFPTERPGTQSRQAL....SNMLRQR..HPGTqfV...PASAS.N...P
  886-  914 (35.65/13.27)	G.TNPVAVP.............NAPPTAggGGGT..M...ANNSRIA...G
 1102- 1137 (40.58/16.25)	G.MNAPAMRPPFMQSGGmqinSAQPNQF..VRGA..M...PNTS.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.66|      22|      45|    1024|    1049|       3
---------------------------------------------------------------------------
 1035- 1077 (26.96/12.82)	SGAPGMQQLVNPQQQaqpqptqqqqpqqqamigQHFNQaggNF
 1153- 1175 (37.70/10.75)	QQQQQMQHNMGQQQH.................nQHYHQ...PF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.41|      13|      45|     154|     166|       4
---------------------------------------------------------------------------
  154-  166 (24.99/14.34)	GSRVTGSSGGMNS
  201-  213 (25.42/14.73)	GSANFGVGGGRNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     141.17|      36|      38|     300|     336|       6
---------------------------------------------------------------------------
  258-  284 (30.81/17.63)	......LDScLSLRQA....QRLLQMISRPDSGAT.AA
  300-  336 (57.13/47.45)	NRVLESLDQ.WRLRVAwLDLQLLCQQLTTVGSGGTSSA
  339-  373 (53.23/37.02)	NQLLEAIAR.AVLDV..FELSTTSSIKEDPDQGGSSSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.20|      28|      29|     454|     482|       9
---------------------------------------------------------------------------
  455-  482 (47.83/35.96)	KSLLSYEPLLSLVMTCLKGQD.EQREAFL
  486-  514 (45.37/28.18)	HSQLSHFIFLPKEDRLYHGEDvKARQAML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.00|      20|     155|     921|     941|      11
---------------------------------------------------------------------------
  921-  941 (33.83/17.39)	AGG.....ASQPQFAGISMvDKQRQQ
 1073- 1097 (34.17/13.96)	AGGnfpmqQTQPQGNMILM.QQQHQQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07264 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DLEPPVIEKTIPKEEICFKTEPMSDQSPRGGTKRGQKTNQRRPRGRRGAAAAAAAAAAATVAGAPPAVGGYQSPVASGMYPPSQPPPQWNAYTSPAPPASQQGTVPTSAAFFPQQSIGPRFPTERPGTQSRQALSNMLRQRHPGTQFVPASASNPSGTNPVAVPNAPPTAGGGGGTMANNSRIAGGVGGVGAGGASQPQFAGISMVDKQRQQQFIRQQIRQQHTGGNVFGQQGPQQTQPQQQQPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQVQMAPVGFANIHTPMNQNMNQNMNQNFNMFQSGAPGMQQLVNPQQQAQPQPTQQQQPQQQAMIGQHFNQAGGNFPMQQTQPQGNMILMQQQHQQPQGRGMNAPAMRPPFMQSGGMQINSAQPNQFVRGAMPNTSQQQAVRLQHQQIVAIQQQQQMQHNMGQQQHNQHYHQPF
730
1175










Molecular Recognition Features






MoRF SequenceStartStop




1) AAAAAAAAAA
779
788