<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07263

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMATDDWKSPGFRQNVAARIEEAIRQSGNPTTKTASEMETHFFQRANNKEDYLNYLARLLIHIKELSAKARAQGGTGVGVAGPQGNVQSNNQQQQVGNISQPQMMNHMNQQHQQMNQQQMNQMVMNQQQQNQQQQMNQQQMNQMGVNQQQQQNQQQMNQFNPNNPNMNIGNPLMQQLGAPNQQQQQQQPQGTAVNNPSSALISQLNQNQQQQNMGPMGGGMPRPRFAGPPGVTATAKMTPQQQQQQQAQAQQQQQMLNQQMLMQQRKQQAEMIQNPSTPQQFAGPGVPSPAQQQQQPMQSMQQQQPMSSGMTSHMSAPSPAYVHSPGNVQLVSSPAAAGRMGGPQQQQQQQRSLSSLLPPPSPSMMNVPTPGGGGMLHTPQGAGMGGMAMTGQGGGMGASGAGTEEQMYLEKVRQLSRFIEPLTRLIGRFGDDDSEKLSKMKIMLDILSNPSKRMPMDTLLKCEAVLEKMDFKRSESGSVAPPSVASVPSLGVAVPTAKDNPPAATPLLSLLETIANQARSPYINHTLQRTFAPAVNSLIGCDIAAPPAPKRRHFDSADDDRADELMDTIEREVANLYPRFKVDMDQMHLMGSQELHLICRLDDKYLPSVPALRIVVPRDYPRMAPFCDSQQPDYDVSSFTRAVLQGLSDRLRHMPHRYTVSQILNCWEMALRHACKPTSNNANNRDVNSLTVALGV
Length696
PositionTail
OrganismDaphnia magna
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Crustacea> Branchiopoda> Diplostraca> Cladocera> Anomopoda> Daphniidae> Daphnia.
Aromaticity0.04
Grand average of hydropathy-0.753
Instability index68.14
Isoelectric point8.92
Molecular weight76770.94
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07263
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     269.50|      33|      34|      90|     122|       1
---------------------------------------------------------------------------
   90-  118 (52.39/12.24)	......NQQQQ...VGNISQPQMMNHMN.QQHQQ.....MNQQQ
  119-  139 (37.16/ 6.69)	MNQMvmNQQQQ..................NQQQQ.....MNQQQ
  156-  187 (56.23/13.64)	MNQF..NPNNP...NMNIGNP.LMQQLG.APNQQ.....QQQQQ
  201-  236 (39.09/ 7.39)	ISQL..NQNQQ...QQNMG.P.MGGGMP.RPRFAgppgvTATAK
  237-  259 (40.11/ 7.77)	MTPQ..QQQQQ............QAQ.A.QQQQQ.....MLNQQ
  260-  296 (44.51/ 9.37)	MLMQ..QRKQQaemIQNPSTPQQFAGPGvPSPAQ.....QQQQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.93|      19|     119|     486|     507|       2
---------------------------------------------------------------------------
  486-  507 (27.19/28.70)	SVPSLGVAVPtaKDNPPAAtPL
  608-  626 (37.74/25.53)	SVPALRIVVP..RDYPRMA.PF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     185.24|      42|      42|     301|     342|       3
---------------------------------------------------------------------------
  301-  321 (27.06/ 6.97)	........................QQQQPM...SSG..M.TSHMSAPSPAY
  322-  364 (66.19/27.45)	VHSPGNVQLVSSPAA..AGRMGGpQQQQQQ...QRS..L.SSLLPPPSPSM
  367-  408 (49.91/18.93)	VPTPGGGGMLHTPQG..AG.MGGmA....MtgqGGG..MgASGAGTEEQMY
  409-  451 (42.08/14.83)	LEKVRQLSRFIEPLTrlIGRFGD.DDSEKL...SKMkiM.LDILSNPS...
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07263 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ARAQGGTGVGVAGPQGNVQSNNQQQQVGNISQPQMMNHMNQQHQQMNQQQMNQMVMNQQQQNQQQQMNQQQMNQMGVNQQQQQNQQQMNQFNPNNPNMNIGNPLMQQLGAPNQQQQQQQPQGTAVNNPSSALISQLNQNQQQQNMGPMGGGMPRPRFAGPPGVTATAKMTPQQQQQQQAQAQQQQQMLNQQMLMQQRKQQAEMIQNPSTPQQFAGPGVPSPAQQQQQPMQSMQQQQPMSSGMTSHMSAPSPAYVHSPGNVQLVSSPAAAGRMGGPQQQQQQQRSLSSLLPPPSPSMMNVPTPGGGGMLHTPQGAGMGGMAMTGQGGGMGASGAGTEEQM
2) MATDDWKSPGFRQNVAARIEEAIRQSGNPTTKTASEMETHFFQRAN
69
1
407
46










Molecular Recognition Features






MoRF SequenceStartStop




NANANA