<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07262

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAHPNLQTNGASLEDCHTNFFALVYLIRLFIFYTDLCGIRWRKLTSEGYSPQPGGGGVYGGQQGNLHQQMRGMAGGTQQPWDYLNDPVLLSYWRCLSNDILCVWRRIPSSSSAPSPGGSSAFPPSFPSGFPNPTTQQGSNGLSTLSGAKELWIFWYGDTSPDLSNLVVPEILNMEGEHGSWENGLSYECRSLLFKALHNLIERCLLSRDFVRLGKWFVQPQEGLDPVCMQQQQQHHQQQDSTNSSTTIPARNGHLSFSFSFFVHGESTVCASIDVRQHPVVRKITHRHLAAAQATSGGVHVMLAPYGLAGVLTGVSYRSSTDHATRKLMEEWRQYYPVECGSNNNPTATGAGAGQQQRGPGPGGGQGGLESASETEDMVEVIVGNVRMRYPTCYVMVCDADSAANSAAFNQLATSEGGMLMTPPASPPLVSNPASISRSISHSSAVSSTLSTASAHHSTQQQLISTVPSCTADALNKIAQAAHSWRPEEARRLAEQAWQDTLLAPVGLLPQPKSTSVDPTAVVLSSSPATTIATPTNEKDSTANLWDFLDPTIKNSCICVKSRRNKTGSNSQGNSVSTNSNAKMATTATMISSSSSSSSSSVPSSSSSSSSSSGKRGGGVPFHHRPSCPAPARAHTAVAGVGQKLLPDNNATAALTPGGLGSVDGVQDRVNRAGMTNTTSTSGATTPAPAPALPTYQRSQAALRGPLSQQSQQQQHSNHGMNSSGNNNSVGPFTLASPASVAPPTPHSHAPPSVPPMDSSLTLSSPHPPASNDPSSNFIPSTPSAIDHNSTSQDQNCSRATPGGAAHTPGGGPKSNQASSAYSPYVALPSVDTPGWPHSAGGGGGSCHATQPRSSGGQQPASCGPPTSMAPTTPNVGGGANGGGSTCSTADLFGIKKIVLPQKEYEDELKEGETAPGLLYDYSSMTAWLFHPVKRMKLGKNSQTPNGDRPADSFDGSASSGKHMNGNLMLDMEVRDSADYDEDGGHNGQSRKRKEPDSCRDEDSNSLNSANAAGGAAKPVNPSSLFTSEGLQASYQDLDKIFDNSDESNDTCPVPTPPGSNKPAGLPEDTALMGHGHHKPPRGGIAAAHPSPGTTMLGGHHLTAGGVNILASAEFSNMFPTPPSHEHPMQSPCGQMEGSVDLMNIDMNNSGHNGIKSEPGSGNSLNGCSPTYLQEDSVNKDWSYVYRPPTVWKVANSSKYAPLPMLPSQTMSPLFLPAPYRPSVNSNSSANHSSGIVDMPRGPMMHQHASIRPFQRLPPMIPPMQQHFPRGGGPAPFSPISPSPYGGLDGIPPSFGGMSGHGPLQRPAMNMGGFPPHGTLKQLLQHQQGQIQSPGFLQHPPGFPHHHPPQQQQLQLQIQQQQQHQPQHQPQQVNNVNNHSNLPECHSLMVNIVLGDSMLNIFRDHNFDSCTVCVCSDGQNWVGTIRGQDAVFYLPESSNPRSSSRALTNSSHYPGMGHGGGPGSSLGLAPPPPNNHEEESCRCNCGFSAIVNRHLAHQAGLFYEDELEIVGVQATQDPGQFKRGSLYAVCHSTDKQEQQMLTRSRMLECGPGVSLYGSDNNSKALGGKGCEKEAVDKGDIISQSIAAVVMEASAPLVDTLPVALMELLREQCLLLHHSSSPLYRAEQLQAATRKASLLHALDYSDGCETARNALTLALYNNSPMPMASPVHQQQAPPPPYQQPQQQQQQQQQQQQQLWNNGPQTPNPYGGMPFNQGMGGFQAGGPVGAGGPGYQGPSPGNMHHPMSPSLHSPTMPVRGRPSTPASAVVGGMPLPMTSPVGMAMQQRQPHPSHGIMAHSTPYSSSPSAGTNGPIVHYWPFLHVQGPNSSQDVIRVMRTLQPLLQDSIQKKRAAAATLWRAPFAVQGPLTWRQFHRMAVRGTEDRCEPQPIPSVMAGFDRDWVAIAPLAIPHWDRLLLEPYSRQRDVAYIVLAPEVDYVLSRTKAFFKELSSTYEMCRFGRHVPYKGLRDGILRVGKSAAAKLANEGHPVDEWFSNIGDSPIASLLRLYAKVCRYHLAPTLINMPMDRTLLDPPAPPTSSRPMQAVPSPMAPPSTTPIHSGDYSGSINQSGMGPPNSGGSNSLQGSSSTFGVHHSSAPSSAMTSVDGKPTSPKTEDGADGTSGHGASGANDASAAVDDEDMEPPSVVIYIVDPFSFGSDNLDLGRLTALGLLRCYHQMLSLLSETIQLNVSLQLISADAILQLGKDLNGASRYDSLRSLALNVFSQCKKLISQPSNVKSLTGFGPAAASDTFLKAKDEKNRAPYRVYIPAYVLAPTKDRTVCDLDPGVSTNGGPGSGPLSFLARPDKYSVLYVSYCLSEDQRWLIAACTDERGELVDSCTIGIDVPNRTKRKRVSVRRFGLQRLMDFILGVISTGVHPWRLVIGRVGRMGHGELKSWSALLSRKNLLRASRHLADICGQCSLVFPSQAPTLVSACLVSLEPDSHFRMMPDQVTPDERFGQQSANSHLSTPEDASCTHILVFPTSATTRSPQTTFHEENINGPDLGDDDLLSALNDDMGDGFEGMSGFDDIFMTWPETDQVNDGTDDLTSDITGGNSGGMNNMGGCGASRSPGASHGGVGGGSPGRGGMRSNMNPESPSGMGGHHAGGSGRQSPRAEQEEVGTLLQQPLALGYYVSTAPTGDMPSWFWSSCPHLARACPAFLKCALHLHNHAVQQSSDDLLLQQQQQQVNNSSKVHPLDSQVTTDVLRYVMEGYNALSWLSLDPKSRDRRSCLPIHIQLLVQLYHALAALV
Length2748
PositionMiddle
OrganismDaphnia magna
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Crustacea> Branchiopoda> Diplostraca> Cladocera> Anomopoda> Daphniidae> Daphnia.
Aromaticity0.06
Grand average of hydropathy-0.461
Instability index58.42
Isoelectric point6.41
Molecular weight293123.20
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07262
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     241.80|      29|      29|     734|     762|       1
---------------------------------------------------------------------------
  749-  776 (37.22/10.32)	HAPPSVPPMDSSLT.........lS....SPHPP......A....SNDPS...S
  807-  839 (29.43/ 6.11)	HTPGGGPKSNQA...ssayspyV.A....LPSVD......T....PGWPH...S
  840-  870 (37.57/10.51)	AGGGGGSCHATQPRS.......S.G..gqQPASC......G....PPTSM...A
 1256- 1281 (33.12/ 8.10)	RLPP.MIPPMQQH................FP.RG......G....GPAPFspiS
 1736- 1765 (40.54/12.12)	PSPGNMHHPM.SP.S.......L.H....SPTMP.......vrgrPSTPA...S
 1766- 1796 (33.17/ 8.13)	AVVGGMPLPMTSPVG.......M.AmqqrQPHP............SHGIM...A
 2581- 2610 (30.75/ 6.82)	PGRGGMRSNM.NPES...............P.SGmgghhaG....GSGRQ...S
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.53|      13|      15|    2023|    2035|       2
---------------------------------------------------------------------------
 1665- 1677 (26.39/13.05)	PMASPVHQQQAPP
 2023- 2035 (26.41/13.07)	PMDRTLLDPPAPP
 2040- 2051 (25.72/12.45)	PM.QAVPSPMAPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     370.93|      66|      66|     564|     629|       3
---------------------------------------------------------------------------
  436-  502 (65.99/24.98)	ISRSI...SHSSavSS...T.LSTASAHHSTQQQLISTV.....PSCT.................adaLNKIAQAA..HSWRPEEARRLA.............EQ................AwqdT....L
  503-  590 (68.01/26.00)	LAPVGllpQPKS..TS...VdPTAVVLSSSPA..TTIATPTNEKDSTAnlwdfldptiknscicvksrRNKTGSNSQGNSVSTNSNAKMA.............TT................A...T....M
  591-  675 (89.24/36.78)	ISSSS...SSSS..SS...V.PSSSSSSSSSSGKRGGGVPFHHRPSCP.................apaRAHTAVAGVGQKLLPDNNATAA.............LTpgglgsvdgvqdrvnrA...G....M
  676-  729 (47.20/15.44)	TNTTS...TSGA..TTpapA.PALPTYQRSQAALRG...PLSQQSQ...................qqqHSNHGMNSSGNNNS.................................................
 1054- 1110 (43.20/13.41)	...................V.PTPPGSNK.PAGL.....P.............................EDTALMGHGHHKPPRGGIAAAhpspgttmlgghhLT................A...GgvniL
 1111- 1153 (57.30/20.56)	ASAEF...SNMF..PT...P.PSHEHPMQSPCGQMEGSVDL............................MNIDMNNSGHN...................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     201.48|      57|     478|     976|    1037|       4
---------------------------------------------------------------------------
  977- 1043 (81.81/48.45)	SADYDEDGGHNGQSrkRKEPDScrdEDSNSLNS...........................ANAAGGAAKPVNPSSLFTS.EGLQASYQDldkifD
 1156- 1228 (42.10/14.24)	................KSEPGS.....GNSLNGcsptylqedsvnkdwsyvyrpptvwkvANSSKYAPLPMLPSQTMSP.LFLPAPYRPsvnsnS
 2058- 2109 (77.57/34.73)	SGDYSGSINQSGMG....PPNS...GGSNSLQG...........................SSSTFGVHHSSAPSSAMTSvDGKPTS.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     319.37|      95|     477|    2139|    2243|       5
---------------------------------------------------------------------------
 1345- 1392 (24.97/ 7.43)	................................................HHHPPQQQ........QLQL.QIQQQqqhqpqhqpqqvnnVNNHSNLPECHSLMVNI......................
 2139- 2243 (138.16/115.22)	MEPPSVVIYIVD.......PFSFGSDNLDLGRLTAlGLLRCyhqMLSLLSETIQLNvslqliSADAIL.QLGKD..............LNGASRYDSLRSLALNVFSQCKKLISQPSNVKSLTGFGP
 2622- 2721 (156.24/103.65)	LQQPLALGYYVStaptgdmPSWFWSSCPHLARACP.AFLKC...ALHLHNHAVQQS......SDDLLLqQQQQQ..............VNNSSKVHPLDS...QVTTDVLRYVMEGYNALSWLSLDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     240.74|      73|     478|    1805|    1915|       6
---------------------------------------------------------------------------
 1454- 1546 (113.97/46.15)	PGMGHGGGPGSSlglappppnnheEESCRCNCGFSAI....VNRHLAHQAGLFYEDeleiVGVQATQDPGQFKRgslYAVCHSTDKQEQQMLTrSRM
 1817- 1893 (126.77/90.59)	WPFLHVQGPNSS............QDVIRVMRTLQPLlqdsIQKKRAAAATLWRAP....FAVQGPLTWRQFHR...MAVRGTEDRCEPQPIP.SVM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.73|      14|     322|    1362|    1375|       8
---------------------------------------------------------------------------
 1362- 1375 (31.70/16.44)	QQHQPQHQPQQV.NN
 1686- 1700 (25.03/11.28)	QQQQQQQQQQQLwNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.49|      21|     840|    1709|    1732|      10
---------------------------------------------------------------------------
 1709- 1732 (40.69/24.17)	GGMpfnQGMGGFQAGGPVGA..GGPG
 2555- 2577 (39.80/16.06)	GGM...NNMGGCGASRSPGAshGGVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.17|      22|      62|      36|      59|      11
---------------------------------------------------------------------------
   36-   59 (40.78/22.34)	LCGirWRKLTSEGYSPQPGGGGVY
  101-  122 (43.39/18.81)	LCV..WRRIPSSSSAPSPGGSSAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.84|      16|      16|    2368|    2383|      12
---------------------------------------------------------------------------
 2368- 2383 (29.30/17.74)	GVISTG.VHPWRLVIGR
 2385- 2401 (24.54/13.39)	GRMGHGeLKSWSALLSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.36|      13|      16|    1632|    1645|      16
---------------------------------------------------------------------------
 1632- 1645 (17.60/17.58)	TRKASLLHALdYSD
 1649- 1661 (21.77/15.09)	TARNALTLAL.YNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.59|      24|     822|    1579|    1604|      17
---------------------------------------------------------------------------
 1579- 1604 (35.17/25.30)	DIISQsiAAVVMEASAP.LVDTLPVAL
 2413- 2437 (40.42/23.12)	DICGQ..CSLVFPSQAPtLVSACLVSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     172.96|      45|     594|     329|     377|      18
---------------------------------------------------------------------------
  276-  316 (57.49/23.93)	....RQH...PVVRKITHR.......HLAAAQATSGGVHVML.APYGLAGVLTGVS
  329-  373 (83.28/48.79)	MEEWRQY...YPVECGSNN.......NPTATGAGAGQQQRGP.GPGGGQGGLESAS
  384-  427 (32.19/10.17)	GNVRMRYptcYVMVCDADSaansaafNQLATSEG.GMLMTPPaSP...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      28.98|       7|      27|    1305|    1315|      19
---------------------------------------------------------------------------
 1305- 1315 (11.13/12.93)	QRPamnmGGFP
 1338- 1344 (17.86/ 6.93)	QHP....PGFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.22|      23|    2218|      75|      99|      20
---------------------------------------------------------------------------
   75-   99 (43.84/32.06)	GGT.QQPWDYLNDP....VL.LSYwrCLSND
 2290- 2318 (31.38/14.91)	GGPgSGPLSFLARPdkysVLyVSY..CLSED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.82|      16|     824|     788|     806|      25
---------------------------------------------------------------------------
  124-  139 (31.16/10.02)	PSFPSGFPNPTTQQGS
  780-  795 (28.66/16.07)	PSTPSAIDHNSTSQDQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07262 with Med13 domain of Kingdom Metazoa
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