<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07260

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAEIGQETVKLSTVVSRTAEEAYVSLRELVEKCREPELSDSDKKISILKYVVKTQQRMLRLNVLTKWCQQVPLIQYSQQLASTLSSHDTCFTQTADSLFFMHEGLQQARAPIYDVPAATDILLAGGYQRLPSCVEDVGIRSTLTEDQQKPTLKKLETLVRSKLLEVSLPKEISEVKVSDGTALLRVDGEFKVLVTLGYRGHLSLWRILHLELLVGERSGPVKLEEVRRHILGDDLERRMAAADNPFVTLYSVLHELCIVLTMDTVIRQVQALRQGRWKDAIRFELMSDGNLGQGGNAVSSQVSQDGETETVLRTPGLKLLYWLDYDKSPGASDGGSCPFIKIEPGPDLQIKCLHSSFVVDPLMDKEAELSLDQSCIDVEKLLLEAICCNRYTRLLEIYKELGRNGHICRAADDVLLCTQEDTEDDTDDSYKKRDDNSSAKGKEVLRVRAYGSSYFTLGINIRNGRFLLHSSKNILESSTLLECEEALNNGSMSAAAVFVSLKTKSVLHLFARLGRFLGLQVYEHGFSAAKLPKNILSGSTMLVMGFPECGSSYFLLMQLDEDFKPIFKLLETLQDPSGKPQTSVDLNHVTRVKNIDIDMMHLLEDELNLSLLDSLPLNNDMGADQNPEIGLLSELSNRASNFNSVLPSSFSSVVDEVFELERGSSALHSVQSPSSMFTSSPASHSGPLARNLYGMRAGTSPKWDVGSQINNFTKVANINTNYNTSPYMTRLSQSSSSSLLSSGPGKSMPAKKLSASKSDQDIPSLRSPYSAEVGLYTTADEDHLVSRLSQQPDLQVSTSAKVIASTNSLPIGTAAGSLYVSRSKSMAEGPDSAIILRQEKGSGKRKLSDMLNLMPSLCLLEVKERSFKRKKLTESSLIQHSSSQMVTKAISKTDGYSYARLIDEANKGNAASNIYVSALLHVVSHCSLCIKHARLTSQMEALDIPYVEEVGLRNVSSNLWFRLPSSRGDTWKNICLRLGRPGSMYWDVKISDKHFRDLWDLQKGSNDTSWGSGIRIANASDVDSHIRYDVEGVILSYNSVEADSIKKLVADIQRLSNARMFALGMQKLLGVSSEERFEDSSTFYDGKVSAGVKGVGEGNDKSSEQMKRAFRIEAVGLMSLWFSFGSGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTAGPLHALAAATRPARAAPVSGLPGITALNPTVAKQSGYIPSQGPTNSGTNTGQLSSGLGGITGASTNTGTPSTHNPQTAAMLAAVAAAGRSGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKNFAVDMRCFAGDQVWLQPATPPKGGPTAGGSLPCPQFRPFIMEHVAQELNGFDPHLTGVQQAVGLGNSNAASLGTGPGSVAQLSANSGNRLGIPSSAGISRLGNQINGLGRAGNSLPASSPSALSSGLPLRRSPGASVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHSQQQQQNPAVAQEELTQAEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLAQAQSGDAAPSQKSRIELCLENHSGINIHGNPEHVSSSKSNIHYDRPHNSVDFGLTVVLDAAHMPHINAAGGAAWLPYCVSVRLRYSFGEKPNVSFIGMEGSHGGRACWQRLDDWDKCKQRVIRTVEMNGNSTGELNQGRLKIIADSVQRTLHVSLQGLKDASAVPGSTVAVFLCTVVANVADSRAGLATISDDGSLILVQLTLDFKPNIPQEAERVVQCNGRVFCLDDERVHRVWLPNEESPGLAMSRAFGDYCLKDFGLISVPQVTRRQITVRDQFIVLASDGVDVLNAEKMFLTQQLTHEKKMARV
Length1924
PositionTail
OrganismDaucus carota subsp. sativus (Carrot)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> campanulids> Apiales> Apiaceae> Apioideae> Scandiceae> Daucinae> Daucus> Daucus sect. Daucus.
Aromaticity0.06
Grand average of hydropathy-0.166
Instability index44.55
Isoelectric point6.71
Molecular weight209687.41
Publications
PubMed=27158781

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
phosphatase activity	GO:0016791	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07260
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     270.38|      90|     174|    1154|    1250|       1
---------------------------------------------------------------------------
 1154- 1248 (137.36/105.53)	PHTKFLEDFINGAEvASLLDCI...............................RLTAGPLHALAAATrPARAAPVSG..LPgITALNPTVAKQ............SGYIPSQGPTNSgtNTGQLSSGLGGITGASTNTGT
 1254- 1388 (133.02/86.15)	PQTAAMLAAVAAAG.RSGPGIVpssllpidvsvvlrgpywiriiyrknfavdmRCFAGDQVWLQPAT.PPKGGPTAGgsLP.CPQFRPFIMEHvaqelngfdphlTGVQQAVGLGNS..NAASLGTGPGSVAQLSANSGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.08|      10|      94|     812|     821|       2
---------------------------------------------------------------------------
  812-  821 (18.39/10.94)	GTAAGSLYVS
  908-  917 (18.69/11.25)	GNAASNIYVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.58|      14|      96|     444|     457|       3
---------------------------------------------------------------------------
  444-  457 (25.85/13.39)	VLRVRAYGSSYFTL
  543-  556 (28.73/15.70)	VMGFPECGSSYFLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     198.78|      48|      96|     632|     684|       4
---------------------------------------------------------------------------
  632-  675 (61.63/30.77)	.................LSELSNRASNFNSVLPSSFS.S........VVDEV.FELERGSSALHSVQSPSS
  676-  710 (35.11/21.95)	MFTS...................................spashsgpLARNL.YGMRAGTSPKWDVGSQIN
  711-  770 (55.66/28.18)	NFTKvanintnyntspyMTRLSQSSS..SSLLSSGPGkS........MPAKK.LSASKSDQDIPSLRSPYS
  952-  988 (46.38/20.83)	....................LRNVSSNLWFRLPSSRG.D........TWKNIcLRLGRPGSMYWDV.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.06|      10|      58|     472|     481|       7
---------------------------------------------------------------------------
  472-  481 (17.43/12.97)	KNILESSTLL
  533-  542 (18.63/14.57)	KNILSGSTML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.41|      19|      22|    1462|    1482|       8
---------------------------------------------------------------------------
 1458- 1477 (31.93/26.44)	Y.GGGWV....PLVaLKKVLRGILK
 1478- 1501 (25.47/20.44)	YlGVLWLfaqlPDL.LKEILGSILK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.18|      25|     314|    1509|    1535|       9
---------------------------------------------------------------------------
 1509- 1535 (40.95/34.76)	NLDQEqpALRFF.VGGYVFAVS...VHRVQL
 1824- 1852 (40.23/26.31)	NIPQE..AERVVqCNGRVFCLDderVHRVWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.40|      15|     413|     143|     158|      12
---------------------------------------------------------------------------
  143-  158 (22.56/19.63)	LTEDqQKPTLKKLETL
  559-  573 (27.84/18.74)	LDED.FKPIFKLLETL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.39|      29|    1103|     291|     332|      22
---------------------------------------------------------------------------
  291-  332 (41.67/41.69)	LGQGGNAVSSQvsqdgetetvlrTPGlKLLYWLDYDKSPGAS
 1408- 1436 (51.73/25.53)	LGRAGNSLPAS............SPS.ALSSGLPLRRSPGAS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07260 with Med14 domain of Kingdom Viridiplantae
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