<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07246

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMPAIIPPLDEQEYADPQMPLAHLDSDNNIIFYHMNSPFFEPNSNNSAVYSTAQGHPNGMQLLNDRPTYEAELRKYNSGLQFIVAGEPKAEGQPWLIQRQHKVENRETGNPETVVEGNYYTQGTRLLMAPSLLDVVQARLLTVSTRMQQMAELSKNMSHWSPATGHTYMPPSYDSVKVATAGSRIGSPALAPTDPDASTSQSQTKDATAAIDPTTSTTQFSDDLFMQSLNLSHAYGDEYMDENPLLGEPGAFVFTNSKSHVDARNKAQEQATQASQASQPTIKTDTQPTSVAPSVVATPKGIATPMALDAPSRKSSLAGLPKEERRKRRKSKGLTSPTTPAGSAS
Length344
PositionHead
OrganismDidymella rabiei (Chickpea ascochyta blight fungus) (Mycosphaerella rabiei)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Didymellaceae> Ascochyta.
Aromaticity0.06
Grand average of hydropathy-0.640
Instability index51.61
Isoelectric point5.64
Molecular weight37351.12
Publications
PubMed=27091329

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364143
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP07246
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.15|      13|      16|     188|     200|       1
---------------------------------------------------------------------------
  188-  200 (23.97/12.66)	ALAPTDPDASTSQ
  206-  218 (23.18/12.03)	ATAAIDPTTSTTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.51|      19|      20|     110|     128|       2
---------------------------------------------------------------------------
  110-  128 (34.67/20.20)	PE..TVVEGNYYTQGTRL.LMA
  129-  150 (23.84/12.23)	PSllDVVQARLLTVSTRMqQMA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.86|      13|      16|      19|      31|       3
---------------------------------------------------------------------------
   19-   31 (22.77/12.54)	PLAHLDSDNNIIF
   37-   49 (24.09/13.62)	PFFEPNSNNSAVY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.63|      12|      18|      58|      71|       4
---------------------------------------------------------------------------
   58-   71 (17.26/18.06)	GMQ.LLNDRPtyEAE
   78-   90 (16.37/ 8.68)	GLQfIVAGEP..KAE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07246 with Med6 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LLGEPGAFVFTNSKSHVDARNKAQEQATQASQASQPTIKTDTQPTSVAPSVVATPKGIATPMALDAPSRKSSLAGLPKEERRKRRKSKGLTSPTTPAGSAS
2) PSYDSVKVATAGSRIGSPALAPTDPDASTSQSQTKDATAAIDPTTST
244
170
344
216










Molecular Recognition Features






MoRF SequenceStartStop




1) IFYHM
2) TPMALDAPSRKSSLAGLPKEERRKRRKSKGLTSPTT
30
303
34
338