<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07245

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDPNYSMDVDDLFGDSEHVNLQNITAVPPVKGLARRVDELGTNGCCQKVAWSKNGCVAYITPDGAAVHLAVFSRDIETGKWDLGKDVALEVPHGREPYPFVHLSWSHLGNDIAVVDAAGRLLNFSCAMALDRMQYTKAELAHPETEADGVVGLHWLAIYPYEQKNQIVWSAEREGEMWKWNIRSHVFHDAHHPIPSKASLIYLKRHGELNLRFQQNDNAWQETSIQLGPMISTQEPFTHAAFASNNDESLLMAAYDAKQRLYLYQIETTWQVPQEKHSQNAGHFDKPGLQVSLVAIEENCGPANTIASELESDTEPRGTAPAQLTQLNFLPVTPDLGDGSLPTIQAVYCRPPNLISMDHLQAQETPHSVLVKWEVHQLQQNQLHPSLDQVTSKKKTIGSVTARTVFQLKRATDFPMHAVVVACIPVWYNMLLAFCYSDGTIEFRRRSTMEMLVNDGNTDTVTSLFQAGFAFPHGEPSLHLALSPNYCMSVCMQQDGSIKLRSLEYQRGTLSIDDEDPRNSAALAALILQSASSANQYFSSDDIFSIMGPLSDKRKRDFTNLLFEGLQVNIDCGIDDMNGNYLMLLGRSPFFVKTLSAMHLLGLKSPVDRSLSSKMAWIILNIKYVTQILTSITRMHGPLEKAVLRPEVVPQFIGICRWIMHFMAYMVDELFSLGRAVEALGPCDLTASKLEQVFAQTNKPAVLLLLSAFPRAMMKLWPQPLHWVKRSADNFTNPNAPTPSPEVRKLYAPLQAAVSELPFDWRWFERLVADTHEQSRGAFKSHGLGDAARNALERDLLLGNLHPVYLPLARRLVTEQLWNSDIAGGCLADRLDAGRLMFFDTTWLGLQESKRAHEWHATHVVDVCQKMIIRGVGTQEHPVTSSTQTGRSRSDSLQSARGDGGVDAEGRRKKQLRRCVRCGSYMEDVTIHQVGYTPHHANWLMSIAKHCVCGNSWMLAPEKKRAR
Length963
PositionTail
OrganismDidymella rabiei (Chickpea ascochyta blight fungus) (Mycosphaerella rabiei)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Didymellaceae> Ascochyta.
Aromaticity0.08
Grand average of hydropathy-0.265
Instability index46.22
Isoelectric point6.34
Molecular weight107905.88
Publications
PubMed=27091329

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07245
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     291.17|      93|     321|     137|     242|       1
---------------------------------------------------------------------------
  137-  242 (143.10/126.98)	KAELAHPETEAdgvvGLHwLAIYPyeqKNQIVWSAEREGEMWKWNI...RSHVFHDAHHPIPSKA.SLIYLKRHGELNLRFQQNDNawqeTSIqLGPMI.STQEPFTHAAF
  466-  563 (148.07/94.11)	QAGFAFPHGEP....SLH.LALSP...NYCMSVCMQQDGSIKLRSLeyqRGTLSIDDEDPRNSAAlAALILQSASSANQYFSSDDI....FSI.MGPLSdKRKRDFTNLLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.08|      37|     321|      11|      51|       2
---------------------------------------------------------------------------
   11-   51 (54.27/53.44)	DLfGDSEHVNLQNITAVPPvkGLArRVDELGTNGCCQK..VAW
  335-  373 (64.82/44.96)	DL.GDGSLPTIQAVYCRPP..NLI.SMDHLQAQETPHSvlVKW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.31|      39|     376|     292|     331|       3
---------------------------------------------------------------------------
  292-  331 (63.57/41.61)	SLVAIEENCGPANTIASELEsDTEPRGTAPAQLTQLNFLP
  672-  710 (65.74/38.92)	SLGRAVEALGPCDLTASKLE.QVFAQTNKPAVLLLLSAFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.15|      22|     574|     256|     283|       6
---------------------------------------------------------------------------
  256-  283 (29.73/22.33)	DAkQRLYLYqiETTW...QvpqEK...HSQNAGH
  832-  859 (36.42/17.46)	DA.GRLMFF..DTTWlglQ...ESkraHEWHATH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.84|      14|     491|      94|     108|       7
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   94-  108 (26.72/17.64)	GREPYpFVH.LSWSHL
  586-  600 (24.12/10.85)	GRSPF.FVKtLSAMHL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07245 with Med16 domain of Kingdom Fungi
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