<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07242

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMRAVTNRKAFCGVTTSQHIRVPTGNERHQPSRSAPNNINYTTTTTTITTTTTSAIPHPPFARTHFASPCKCDHFSAFTRPCDARAPDRENPSSSARNHSPFTYTPAPPHNLSRSLNLHFYTLQHSVHCKHTCTPPQSPGNRLHALNTNRDCAPTTRGERADGLHDGAQTMPGILMMNHSATDSARDGEIKKRSFDGKLVNGNDVRNDAAVTNGNTGKLAINGASTAVAAPTMDQYADLPPKIAHIGPEAYHPLSKLLARIAQECYNALEDTLHKMSGMSLGQQANGVMTNGVPPQDNPEVNKRKKLLLLKFAQENRAKFIKLLVLTEWGQKSAVDIGKVIDLYSWAKEQAAHMDFVDEQVNQIKILSAYARENNPDIRTALEVLSTGNASWIPTLDYIPPDPISSDKALKLLRAMNTSLSIRLNVHEILPRHLRNWRIESGRATFVINNELEFDVISFVEDTSDQWWFIDLRLLFVPAPTIEIDSRFFLTLKQQADYVLHEKGLGGLFDFLHNFVLTHKISVLRTQAAELARSGWAGSLKVEPVHRELVVQYWTDRPGKKNWIEFGTTSNKPKNGKTSWRGAPLPSLTARWFCHGREVADMDLGVDWKDISMERILKRVIALHAAQILQSAREHFDTSLGVDLSMSGSEPTDCSLAVSLGTASNSVTLSLEPITGSYIIRPASALSARAEFALNQGREPVQIAGILTSMLSQTLRDHIQRTAQQIGWQPITRQALRSDVVRAAVKAHVLDYALYSPRGWTPTWTLAAMVDTAGDSWWILQLSSNGTIIDYAEQILMERYEGSSLAINRSTLCSVERVAVQLISFRVTVRQLEKQQKMFALRRKFSPSSNPVEVGRVVQGWALYLQTTDLLTTKSGEQPWLEDNIAIACEGLKSNGRSVWHIASGRMVKNAAADMQKLMSTSPQSNFKFTADGSFRILLATPFGSDILGELRARLRDVNRLRSFATTLQKRQMRLASSSLQRVQFRYGPSQHTAAVSFASEKEIAIEIPPLNPHHRIRRFLTSIANDCDPSLPLLSFGDANGLDHFCTALILTRSLLGVLSDLETQTPGDFRNPAVHVHSIFKYRLTYENPLCTFDIRLQPKDDKVYWFIEDNLKRPHDVRPTPERNPSHRRLDNLQGKLKELFRSRAEGWFGTRNGLVAELDAVPDVLRKLNDTVLNCKMEGGYKAPPPLEPSAQTNGNASSLVRRPSQQQQNRPQQISPQMARRQQPNLNQQPNGRLQQNGQRQQPTPQQVQHMQHLQQQARAAQQQARQKKGDIIEID
Length1280
PositionTail
OrganismDidymella rabiei (Chickpea ascochyta blight fungus) (Mycosphaerella rabiei)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Didymellaceae> Ascochyta.
Aromaticity0.07
Grand average of hydropathy-0.456
Instability index47.13
Isoelectric point9.40
Molecular weight143247.94
Publications
PubMed=27091329

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07242
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.61|      26|      26|    1207|    1232|       1
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 1207- 1232 (50.13/27.46)	P.......SQQQQNRPQQISP.....QMARRQQPNLNQ
 1234- 1271 (36.48/17.98)	PngrlqqnGQRQQPTPQQVQHmqhlqQQARAAQQQARQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.36|      19|      26|      75|      99|       2
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   53-   71 (37.68/13.32)	SAIPHPPFART.HFASPCKC
   75-   94 (31.68/15.04)	SAFTRPCDARApDRENPSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.73|      19|      26|      97|     115|       3
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   97-  115 (36.77/23.49)	NHS.PFTYTPAPPHNLSRSL
  123-  142 (34.95/21.89)	QHSvHCKHTCTPPQSPGNRL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     146.28|      41|      43|     344|     384|       4
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  311-  343 (39.49/21.11)	.FAQENRAK..F...........IKllVLTEWGQKSAVDIGKVIDLY
  344-  384 (68.74/41.87)	SWAKEQAAHMDFV.DEQVNQ...IK..ILSAYARENNPDIRTALEVL
  390-  425 (38.04/20.08)	SW....IPTLDYIpPDPISSdkaLK..LLR..AMNTSLSIR..LNV.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.93|      18|      37|     589|     606|       5
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  589-  606 (35.32/21.13)	ARWFCHGREVADMDLGVD
  625-  642 (30.95/17.63)	AQILQSAREHFDTSLGVD
  645-  657 (18.67/ 7.79)	MS....GSEPTDCSLAV.
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.77|      15|      17|     458|     472|      10
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  458-  472 (29.47/16.70)	FVEDTS...DQWWFIDLR
  475-  492 (21.30/10.03)	FVPAPTieiDSRFFLTLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.76|      10|      17|     873|     885|      11
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  873-  885 (15.78/15.72)	KS.GEQPWledNIA
  892-  902 (15.98/ 6.80)	KSnGRSVW...HIA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.54|      10|      17|    1003|    1012|      12
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 1003- 1012 (18.71/ 8.08)	IAIEIPPLNP
 1023- 1032 (19.82/ 8.93)	IANDCDPSLP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.24|      24|      53|     146|     169|      14
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  146-  169 (44.05/32.56)	NTNRDCAPTTRGERADGLHDGAQT
  202-  225 (40.19/28.95)	NDVRNDAAVTNGNTGKLAINGAST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.62|      11|      20|     712|     722|      15
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  712-  722 (19.79/11.55)	QTLRDHIQRTA
  733-  743 (17.84/ 9.74)	QALRSDVVRAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.00|      18|      26|    1125|    1142|      19
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 1125- 1142 (31.09/21.36)	RNPSHRRLDNLQGKLKEL
 1154- 1171 (28.90/19.30)	RNGLVAELDAVPDVLRKL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07242 with Med14 domain of Kingdom Fungi
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