<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07241

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSGVESLKDVALRPWPANKKDELSRDALLQQIEQLTTERGHLRDITEKSLQADIEAGKDVPDDAEEGSEDEEEEKDVPSRKEKMDEIFKMQMEMAGHLDWARFAATNALDLISLVLSADPNKRAPTSFSHTFREAGLNQGLPFASMGVARENHEQHHYKQEELDRKEELHRRQDLVSKAARMEALDAATDEILKAAKSLEKEVRRETKYWQEIVSISDKGWPIQRLRQNARHVPFGVRYGLPEASDHFKARGFAPLRMAKDGSIVLDPNLSLRPKTLRVRISEGGNITGSSQLPVESAGEGLAVEKSIRLARDSLLEEELYHEMSLETRQLLPYGVQLRGSVISVDEPGDNAFANRRLLIDCIPRDDRNSDNEEHTNDWLAHNVAEALRLLLTHEHSMRLYRRTQLPPPLTARKQEKKSPPLLRTLLAMLHHLQSVDALFTYLDTVSSTLRSAGLETSLTTSREESWIKLRESLGKSAKKDLSATDQLLDIFTKPFNGKATLTLPWSQGSQTEQLTIAIRTVIGAPTFGTEYKLTLPSSLTTDLGLSTENKFQSTADITSYIDWILSLYIAHRVLKNEYANRAAVKGNEARVTIMGKVSKKGASVKRDVSIDLRDGILALHLADSSLKGSSQESRSWPGKGEEGPLKEQVKSWVG
Length655
PositionHead
OrganismDidymella rabiei (Chickpea ascochyta blight fungus) (Mycosphaerella rabiei)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Didymellaceae> Ascochyta.
Aromaticity0.05
Grand average of hydropathy-0.580
Instability index49.16
Isoelectric point6.12
Molecular weight73452.11
Publications
PubMed=27091329

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP07241
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.42|      14|     273|      68|     123|       1
---------------------------------------------------------------------------
   53-   66 (24.87/ 7.64)	DIEAGKDVPDDAEE
   70-   83 (24.55/46.18)	DEEEEKDVPSRKEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.46|      39|      51|     256|     306|       3
---------------------------------------------------------------------------
  256-  300 (51.93/54.03)	LRMAKDGsiVLDPNL....SLRPKTLrvrISEGGNITGSSqLPVESAGE
  308-  350 (59.52/30.34)	IRLARDS..LLEEELyhemSLETRQL...LPYGVQLRGSV.ISVDEPGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.65|      24|      31|     491|     517|       4
---------------------------------------------------------------------------
  491-  505 (18.52/ 7.33)	..............IFTKPFNGKATLT..LP
  509-  537 (34.14/27.80)	GSQTEQLTIairtvIGAPTFGTEYKLT..LP
  538-  563 (26.00/10.25)	SSLTTDLGL....sTENK.FQSTADITsyID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.79|      37|      46|     402|     440|       6
---------------------------------------------------------------------------
  402-  440 (59.36/42.78)	RRTQLPPPLTARKQEkkSPPLLRTLL..AMLHHLQSVDALF
  451-  489 (54.43/33.14)	RSAGLETSLTTSREE..SWIKLRESLgkSAKKDLSATDQLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.30|      25|      51|     565|     589|       7
---------------------------------------------------------------------------
  565-  589 (42.22/26.37)	ILSLYIAHRVLK.NEYANRA.AVKGNE
  617-  643 (33.08/19.20)	ILALHLADSSLKgSSQESRSwPGKGEE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07241 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ELSRDALLQQIEQLTTERGHLRDITEKSLQADIEAGKDVPDDAEEGSEDEEEEKDVPSRKEKMDEIF
2) FASMGVARENHEQHHYKQEELDRKEELHRR
22
143
88
172










Molecular Recognition Features






MoRF SequenceStartStop




1) GKGEEGPLKEQVKSWVG
2) LKDVALRPWPA
639
7
655
17