<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07237

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMSTCSLETLLRYSYLHGYNCTQWAGPARQCLQQSEQDLTQDLCDLLLKHLFSTARVHSLLLDSYLTYALLGDSPTATSTQRRSNDNTTAMVNRKQLLSRLVNRDARFATHSEYSHQWTTILRLLPSLLTEVDADRTESISWAPIISKLLVLLSHIVSGGVYPQRKSRRRRVEHNDNDMYHSDSDSDDRVNQQTQGDDFTASQQFNFSYTNNNTQMAADSQMTLDPDATFDLDATQPDPNNERDDHSKRISEGDNSFISGGNRTTTTTATDSVTAGGDSLSDPSGLLQKQDSSLVDPLQHPSQSSSLYPSTWNGSTVISTSNMDSDCLEWENALSAAKITIDLIEKKDPWGTCREILLSDDKKASSPTKSAIPSSVSNAYIQKLFLLIERLTDKDLEQRLAVQMKYHDLEDEGAARAMPSAGVMGLVYYMVQIRPGLDDDALVDRLIKLQTIKGSFDESFYLELWFAALTGLREASHSTTCQPTISPDNKPNDRRCNTTVAINRLLWKNLVLVKLPYLIRRFQEQKEKDQVGRRDFYRKAQSTKSDAIESSLVELRKFTDLLNACSPVACCPEFHVPSSKPSKLMDRLIANDAQPPPFTDDDDDMMHMIDDARYSTDINAPSIIQSLRSISTEDIFTSLVRSCQHHTLLNDNSALLNSIDSTTTSKAERYDYDGGSNKLKKQYSSFSLLDDDMMDDLDQESDSGEKPDALAQVDENIQQRIKAIRSTLTKASVTELIHLGIVSLIHWRRIVDFLLEVLNDSVQEDRLADLVCVCDALNDCPAAIDLILQLYPPTTLLAPLETVCNTWNPTENYMDVDDGNSSVDGDDMDGLQTWYFKFGKVWMLVLLVMSKSDVAGNIFADKQGMCYRYFMTGPVIYGTCDSEVEDVVNRWLSAMGGDGISDELLRTTKVQMLLQAVPTLIDRLLTIHEAGRLTSLTDVMSYFCKQFLHFLLIPGVTSTICEALLNRDDGSTVLICMSHLFLHPSFHDAAIQLCGPQVLSSLYAYTERQRQYKRLYPSTPQQQTNEQVNELERFFITNLDLQQVGSPATTAGIVTRRTLFEKTQAMFHHIVKSGRSMHMADGVTKALWDPVADPPPKQAVSHFLDLALFQAALQTGGQHWFIGMIVDQVVEAGKSGGAVRAAELGSCLLTTPLIPHTCLSILRRLLQDVIPATLDSCAATASFFQGQTLGVFVSDCLVSMHEDAVLLGQQFFEALAIDRVRSDDDEVQASQTGFVIGVIWLGGGI
Length1244
PositionTail
OrganismAbsidia glauca (Pin mould)
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Cunninghamellaceae> Absidia.
Aromaticity0.07
Grand average of hydropathy-0.275
Instability index48.13
Isoelectric point4.91
Molecular weight138745.90
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07237
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.78|      19|      32|     766|     784|       1
---------------------------------------------------------------------------
  766-  784 (35.24/20.23)	LADLVCVCDALNDCPAAID
  796-  814 (37.54/22.02)	LAPLETVCNTWNPTENYMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     353.24|      87|      87|     523|     609|       2
---------------------------------------------------------------------------
  447-  537 (111.11/55.61)	KLQTIKGSFDESFYLELW.FaalTGLREASHSTTCQPTIS.PDNKPNDrrcnttvAINRLLWKN...LVlvKLPY......LIRRFQEQKEKDQVGRRDFYR
  538-  624 (148.88/76.83)	KAQSTKSDAIESSLVELRKF...TDLLNACSPVACCPEFHVPSSKPSK.......LMDRLIAND...AQ..PPPFTDDDDDMMHMIDDARYSTDINAPSIIQ
  625-  697 (93.25/45.57)	SLRSISTEDIFTSLVRSCQH...HTLLNDNSALLNSID.STTTSKAER........YDYDGGSNklkKQ..YSSFSLLDDDMMDDLD...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     248.18|      70|     211|     916|    1001|       3
---------------------------------------------------------------------------
  854-  914 (62.32/33.03)	AGNIFADKQGMCY..RYFMTGPV...IYGTCDSEVEDVVNRwlsamgGDGiSDELLRTTkvQMLLQ...................
  929- 1001 (109.58/113.81)	AGRLTSLTDVMSYfCKQFLHFLL...IPGVTSTICEALLNR......DDG.STVLICMS..HLFLHpSFHDAAIqLCGPQVLSSL
 1157- 1214 (76.28/47.76)	..............CLSILRRLLqdvIPATLDS.CAATASF......FQG.QTLGVFVS..DCLV..SMHEDAV.LLGQQFFEAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.03|      22|     628|     186|     208|       4
---------------------------------------------------------------------------
  186-  208 (37.08/30.02)	DDRvNQQTQGDDFTASQQFNFSY
  816-  837 (42.94/29.97)	DDG.NSSVDGDDMDGLQTWYFKF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.79|      45|      48|       9|      55|       5
---------------------------------------------------------------------------
    2-   51 (69.18/43.60)	STCSletLLRYSYLhGYNCTQwAGPARQCLQQSEQDLTQDLCD..LLLKHL......F
   52-  107 (59.61/29.00)	STARvhsLLLDSYL.TYALLG.DSPTATSTQRRSNDNTTAMVNrkQLLSRLvnrdarF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07237 with Med5 domain of Kingdom Fungi
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