<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07224

Description RNA polymerase II transcription cofactor
SequenceMPMPMPMQPSGALNTSVDRIPLGAVVSTTDCSPRSCLVSCRPPPAAPSALPFRCPTPSHLLPGRAQHNDERAPGAMTSRPGPGIHEQSRGSGVPSRSQPQLQSQPQSQSQSQAQVRRQPSKPLNTNPATNTATNTATTLPQPIDPALEHVRPPALQAAADTARPLPQGRPQLFYGTAPHDAYAHAHAHAHAHAHVHAHAHVHAHACAHAYACDLPIHPSFPYQPTATLPLPPRPGSVHLRDALTHRRIVPGGTGVKEHPSIHPPELITPPVHFPGGEAADVFPWTGHNPEDTLTEALVKAGISNKPQIMNETNTARPSLWSNLKNKSGLSTLSTLFVAVLEKRQQTGRLQEPNTFKPPPRLTLRDSTREQWLHDLANPAVGVRRLSRTIPHGLTGKVLLEQCLNKNIPLTRALWLAKCVGINELRSHKRKGQAGTVTWVRGWTSSVEHFLDGIVSSMGTGEWKPRITYSVKLATHLYKECLLDVDHFLDWMLHNLEACSPERLFVWLTLLSVPHYWNDILSCRMRGKRLAEALLNHVTKLSQHEASLLSQLLENTLIDLLDKRPACLLLPTTWHQHSATLQALADKINHPQLLHRVQKLDDRNRRLQQSSKTAPAASMTSAGRVYRILDNVDYNRIVRIDEVSTDCMEVISNPVHLVSALLEWACSHYRQGSHRVCLATRLLRRWGHLGADIYECVTTYLEGMSWAKTGDERIVFKVISELVRSKTFAAGRYMQWLIATGSIAQNLDLSVPAAWPVRLITEIPISGLPDQIRTLRATLLRGTAYSADWEDQCLEHAKLSISQQMPVLCGMGYSTLDHPKLEIGKLGSTVRIELGIWLRQQVAWYAELNEHVPTKDPAVEETATVSLITPHDFDIVRSYLEQFDHLSLLADVVNIVTSSLDPTVLASATDTMHYHLKAFRAIGAFDSLFGKVVTRYASIRTIRFPERELLLSLTNLTRTLQLDGQLLQLLNYDLSRLDQKNSMAACSPASDNMGEVMYNISSNVEDEIERILSSGNSMDQQVMARMLRKITGSLQDCVSKGVLQSDHYSNWFYRLRSFDDSTFDVVLNEWTNLCLVNHQVEVLFLALPTLVGSGCMPLSGFLESLRAYVAKTATGQPEIAFRVASEGLYSLLPSDVLARNWSSSDGYRFRLEQRKLCYEADARVLQFISELVGLGTALPVQKVGQQLSSLLSSSSVLDILKHYTLADTTHLSKLSTGGSNGDLKIQYLKVPFGLLLDPHGNLDLSAKSPEQQVLEIFDIASELSMPFCRSMVQQIFEFDSVSTECLADGLSAALLSAIKSALEKDQPSALELLATLDSALTVKIRQQAEHEIIGASSFLTTSSLEPQSFSLLSPALVQKYLTIIDLTAGEVSDATEPSTMSMALTERLKGVAQALTYLDGVGKLHTHTDHLTVSDLYTWTNALFRVLISHKTSALGNATHQHQTALMAALRSLIVHPLLELYPHIAEHIFDVTVVLSDLLSDDVRIQLARAESTAPADDPRFSFIVGSARPIDGWLVLTKPVNPPQSAQNFAPSQSQTPATIQSQYQSPQMPNSGAPSPQQRYFNPQQQRQQQMQAQQLRSYPQYPQHTHPQNKMLPAQLQRNPSNPTPLQQMQHMQHMQSLAQQRATQPSPVQSQRPTPMASGPGATNGRLPAAQAKEVRQFPYVQPRWEILAESSGNPNANETAINLSLFGARRA
Length1696
PositionKinase
OrganismDidymella rabiei (Chickpea ascochyta blight fungus) (Mycosphaerella rabiei)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Didymellaceae> Ascochyta.
Aromaticity0.06
Grand average of hydropathy-0.257
Instability index53.45
Isoelectric point7.68
Molecular weight187593.68
Publications
PubMed=27091329

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07224
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     279.59|      39|      39|    1552|    1590|       1
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   55-   88 (38.44/14.28)	....PTPSHLLPGraqHNDERA.PGA.....MTSRPGPGIHEQS
   90-  127 (59.81/26.31)	GSGVPSRSQPQLQ...SQPQSQ.SQSQ.A.QVRRQPSKPLNTNP
 1552- 1590 (75.85/35.35)	NSGAPSPQQRYFN...PQQQRQ.QQMQ.AQQLRSYPQYPQHTHP
 1592- 1629 (49.09/20.28)	NKMLPAQLQR..N...PSNPTPlQQMQhMQHMQSLAQ.QRATQP
 1633- 1667 (56.40/24.40)	QSQRPTPMASGPG...ATNGRL.PAAQ.AKEVRQFP.YVQ...P
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.49|      14|      21|     179|     193|       2
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  179-  193 (26.22/15.59)	HdAYAHAHAHAHAHA
  196-  209 (31.27/14.69)	H.AHAHVHAHACAHA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.72|      14|      21|    1243|    1262|       3
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 1243- 1257 (21.43/ 9.48)	LS.AKSPEQQVLEiFD
 1264- 1278 (23.28/13.36)	MPfCRSMVQQIFE.FD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.48|      23|      23|     243|     265|       4
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  243-  265 (43.08/28.42)	LTHRRIVPGGTGVKEHP.SIHPPE
  267-  290 (37.85/23.92)	ITPPVHFPGGEAADVFPwTGHNPE
  293-  308 (17.54/ 6.46)	LTEALV...KAGISNKP.QI....
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.32|      21|      36|     527|     547|       5
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  527-  547 (34.18/22.26)	KRLAEALLNHVTKLSQHEASL
  562-  580 (35.29/23.28)	KRPACLLLP..TTWHQHSATL
  586-  606 (33.85/21.96)	KINHPQLLHRVQKLDDRNRRL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.38|      24|      25|     779|     802|       6
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  779-  802 (43.96/27.00)	LRGTAYSAD...W.EDQCLEHAKLSISQ
  807-  824 (33.73/19.01)	LCGMGYST..........LDHPKLEIGK
  825-  847 (17.68/ 6.47)	L.GSTVRIElgiWlRQQVAWYAEL....
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.29|      20|      25|     130|     153|       7
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  141-  162 (32.63/17.36)	QPIDPAL...EHVRPPalQAAADTA
 1509- 1531 (33.66/ 9.80)	RPIDGWLvltKPVNPP..QSAQNFA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.24|      14|      25|     481|     498|       8
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  481-  498 (19.54/23.24)	LLDVDHFldWmlHNLEAC
  509-  522 (27.70/15.93)	LLSVPHY..W..NDILSC
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.57|       9|      37|       4|      13|       9
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    4-   13 (15.62/13.35)	PMPMQPSgAL
   42-   50 (18.95/ 9.91)	PPPAAPS.AL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.26|      27|      42|     356|     397|      10
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  356-  397 (26.97/42.09)	KPPprLtlrdstreqWlhdLANpAVGVRRLSRTIPHGLTGKV
  410-  436 (48.29/23.52)	TRA..L.........W...LAK.CVGINELRSHKRKGQAGTV
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.66|      23|      25|    1292|    1314|      11
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 1292- 1314 (34.82/21.72)	ALLSAIKSALEKDQPSALELLAT
 1318- 1340 (35.85/22.60)	ALTVKIRQQAEHEIIGASSFLTT
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.63|      13|      23|     651|     667|      12
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  651-  663 (23.30/ 6.83)	SNPVHLVSALL.EW
  672-  685 (19.33/10.99)	SHRVCLATRLLrRW
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.83|      29|      43|     855|     892|      13
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  855-  892 (42.08/43.89)	DPAVEETATvslitphdfDIVRSYLEQFDHL....SLLADVV
  900-  932 (45.75/27.48)	DPTVLASAT.........DTMHYHLKAFRAIgafdSLFGKVV
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.44|      21|      21|    1177|    1197|      15
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 1177- 1197 (31.94/17.11)	LPVQKVGQQLSSLLSSSSVLD
 1222- 1242 (34.50/19.09)	LKIQYLKVPFGLLLDPHGNLD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.43|      12|      25|    1026|    1037|      20
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 1026- 1037 (21.82/12.26)	LRKITGSLQDCV
 1054- 1065 (19.60/10.26)	LRSFDDSTFDVV
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.02|      10|      25|     438|     447|      21
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  438-  447 (20.32/12.81)	WVRGWTSSVE
  462-  471 (19.69/12.17)	WKPRITYSVK
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     150.94|      40|      62|    1372|    1415|      24
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 1344- 1370 (36.73/18.47)	....EPQSFSL........LSPAL.....VQKYLTIID.LTA..GEV
 1372- 1415 (58.53/46.80)	DAT.EPSTMSMALTERLkgVAQALtyLDGVGKLHTHTDHLTV..SDL
 1436- 1478 (55.68/32.07)	NAThQHQTALMAALRSL..IVHPL..LELYPHIAEHIFDVTVvlSDL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07224 with Med12 domain of Kingdom Fungi
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