<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07219

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDHNAKRQRLDTSGRYSPASPPFDVAAKASGHTTKPSQPRTPTSPPCASMNSQFNGRFAVTATSASPAKTPPSSATMAQSASQPATSASIQHPFPTPASTTGHSYSTNMDSDGDAVMGDGSEQSARGLGLGIHTHSNHNRQGQALFSDKGGLKAAEGISGSRLFLSSDETYQHSRPHGSQNLFRLYGLERLAKSVARVDPLTGEKINKLRKSYEGHIKTLQIAGKPKAVKMDDVFSGPLGLPDEHWDAVNTGKEPWRKLNTEQTALEPDFSSLLNSAFAGMGPGSLPPSDASKYKAYIGTDDAIRAKPVAEAPPHRGAPFPSSAPTPSSHPLPRRPERSGSKRQYNEDSYQGYSEGYGDDFAADSTGGEDNARGNFKRRKTQFERAAHSVEVGGARR
Length398
PositionHead
OrganismDidymella rabiei (Chickpea ascochyta blight fungus) (Mycosphaerella rabiei)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Didymellaceae> Ascochyta.
Aromaticity0.07
Grand average of hydropathy-0.851
Instability index46.30
Isoelectric point9.37
Molecular weight42490.22
Publications
PubMed=27091329

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP07219
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.12|      21|      23|      43|      63|       1
---------------------------------------------------------------------------
   19-   38 (33.56/15.68)	PA.SPPF.DVAAKASGHTTKPS
   43-   63 (37.44/18.33)	PT.SPPCASMNSQFNGRFAVTA
   68-   89 (30.12/13.33)	PAkTPPSSATMAQSASQPATSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     236.81|      79|     112|     175|     255|       2
---------------------------------------------------------------------------
  175-  217 (53.68/20.39)	.....................................................................SRPHGSQNLFRLY.GLERL..AKSVARVDPLTGEKINKLRKSYEGH
  218-  331 (102.03/52.01)	IKTLQIAGKPKAVKmDDVFSG.PLGLPDEhWDAVNTGKEpwrklnteqtalepdfssllnsafagmgpgSLPPSDASKYKAYiGTDDAirAKPVAEAPPHRGAPFPSSAPTPSSH
  334-  391 (81.10/34.63)	PRRPERSGSKRQYN.EDSYQGySEGYGDD.FAADSTGGE..............................DNARGNFK.RRKT.QFERA..AHSV.....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.14|      26|      28|     103|     130|       3
---------------------------------------------------------------------------
  104-  130 (43.81/29.87)	HSYStNMDSDGDAVMGD.GSEQSARGL.G
  134-  161 (39.33/17.85)	HTHS.NHNRQGQALFSDkGGLKAAEGIsG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07219 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DAIRAKPVAEAPPHRGAPFPSSAPTPSSHPLPRRPERSGSKRQYNEDSYQGYSEGYGDDFAADSTGGEDNARGNFKRRKTQFERAAHSVEVGGARR
2) MSDHNAKRQRLDTSGRYSPASPPFDVAAKASGHTTKPSQPRTPTSPPCASMNSQFNGRFAVTATSASPAKTPPSSATMAQSASQPATSASIQHPFPTPASTTGHSYSTNMDSDGDAVMGDGSEQSARGLGLGIHTHSNHNRQGQALFSDKGG
303
1
398
152










Molecular Recognition Features






MoRF SequenceStartStop




1) RGNFKRRKTQFERAAHSVEVGGARR
2) SKYKAYIGTDDAIRAK
374
293
398
308