<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07216

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDSMVKEWTVFLDRCLNQRVPADLFDAATTQLYRTSPLPGRKLAGLLLKPRSARANSVDPRVIVYLERLLALKRVDASDVLSATFYYSKDRLPKNDGHLTENEPRWHNASELEEVVCHRLHKAFAAEDRPTNNSEGMQTLIVVTRWMQAMVTSHTSDTMMQAMAGISQQPQQQSINVREALGVLVVGLIENSKILLILSHHTATDLRKRLAQSLASFIPFLSHNSLGSQSSLEIANRLEMSQKQHSLYEKPANIEGVPNEHANLEVAALQLEAVMDLPLVSTRAGLYVFVNSLLVARPLTDEFTIINYLHSRYKIDAQNMAADLITASFDVLANAMYRSEPSSTMFLLKSFLINKVPVLLSQLSGSIYPMTPEICITQALSHVDPNAFPAFSQGFDDIMGGNNSLSDVRQDFLNACALHGHIATNTVERLLGEPPIQGPPATKYDKKTLLDQCKNNFDKVNAYIDEMENLDGNAGAIFIAHLCETQVTMYLKHICNLLSKKPQCLDVMLQFTSPASILRPLCQFLDEWHYDSDQGEYQPVYDEFGAILVLIMAFVYRYDLTHHDIGINHESFIARLIERGNHSVAPDNLTEEQGRHLASWLKGLYDSGNEGLSNDVFASCRPQDFYLIVPTFFSQTVMACSAGVLSLETVKGGLEYLGETFLLPSLIGGLSWMASHALKQTHNDLDAMMRIFHQAILSVPSSGDAQAMHSTIIAMVSSRLEKCFRTLQRRDPHRTNIEPLLQAIKGNAHYGRSTYASIRELEQWTNAPNSTLNTALRHTIQQLAQWASTAAINPNPPSYTHRQVYAASNMLGVYQTVRAIVDEVKAQTEAGNGAAALDIGVSIICAPTVEDSPIPVDWIGSSISAPAPPRTRINLREMLKHLFDNALSLITTDPSSAEAIVRLHRRVEAQLASVGQAGLQAPVISLPSVSMDSMQAQNISDDINKAMEDAATASLANDMEIPSMDKKALERSMEELTGPEGLNLSGIGMETGTGMASDMDANLGSLPDLDLSDMTGMGMSMDMDMDMNMGGGGEDDWGLDFDNM
Length1044
PositionTail
OrganismDidymella rabiei (Chickpea ascochyta blight fungus) (Mycosphaerella rabiei)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Didymellaceae> Ascochyta.
Aromaticity0.06
Grand average of hydropathy-0.143
Instability index44.27
Isoelectric point5.17
Molecular weight115115.76
Publications
PubMed=27091329

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07216
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.29|      22|      25|     978|    1002|       1
---------------------------------------------------------------------------
  978- 1002 (34.69/32.49)	G..PEgLNLSGI.GMetGTGMASDMDAN
 1004- 1028 (37.60/22.84)	GslPD.LDLSDMtGM..GMSMDMDMDMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.37|      17|      26|     571|     587|       2
---------------------------------------------------------------------------
  571-  587 (29.43/19.53)	SFIARLIERGNHSVAPD
  599-  615 (30.93/20.92)	SWLKGLYDSGNEGLSND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.45|      42|     185|     672|     721|       3
---------------------------------------------------------------------------
  672-  721 (65.33/57.18)	WMASH....ALKQTHNDLDAMMR.IFHQAiLSV....PSSGDAqamhstiIAMVSSRLE
  858-  908 (59.13/34.56)	WIGSSisapAPPRTRINLREMLKhLFDNA.LSLittdPSSAEA.......IVRLHRRVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.69|      17|     240|     297|     315|       4
---------------------------------------------------------------------------
  310-  333 (18.26/ 6.64)	HSRYKIdaqnmaaDLITASFDVLA
  334-  350 (26.42/14.39)	NAMYRS.......EPSSTMFLLKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.55|      27|      27|     909|     935|       7
---------------------------------------------------------------------------
  909-  935 (45.43/27.11)	AQLAS..VGQAGLQAPVISLPS.VSMDSMQ
  936-  965 (36.12/20.15)	AQNISddINKAMEDAATASLANdMEIPSMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.19|      13|      27|     517|     531|       9
---------------------------------------------------------------------------
  517-  531 (22.84/17.23)	ILRPLCQFLdeWHYD
  547-  559 (23.35/11.34)	ILVLIMAFV..YRYD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07216 with Med5 domain of Kingdom Fungi
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